Protein Alignment Nepl12 and Nepl5

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_609022.1
• Gene: Nepl5 / 33892
• FlyBaseID: FBgn0031808
• Length: 684
• Species: Drosophila melanogaster
• Alignment Length: 760
• Identity: 172/760 - (22%)
• Similarity: 291/760 - (38%)
• Gaps: 195/760 - (25%)

  Fly    42 SSTNRSAAEYQLQE-YAEFMKSYMNQSVEPCENFYEYACGNYRNVKPDRYSPGSR---------- 95
            ::..::.|...:|| .||.::|||:....||||||:|||||::..:.:::|...|
  Fly    21 TACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRYQ 85

  Fly    96 ------SNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAVAQRFYNACLGANLHPFNAADPAYL 154
                  ..||.:.:::....|.||.|.:.:...:.||.|...:.:|.:|  ..|.|:|.  ..||
  Fly    86 GQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILEQMRLYYRSC--KRLKPYNL--KKYL 146

  Fly   155 SLIRSIGG--FPAVDGDAWKASNFNWINMSAHLANYGANG-LIRETLQLRYP----FEPYTKLP- 211
            .|:.....  :|:| |..|:...|:||.....|..:|.|| |:||.:..|:.    :..|...|
  Fly   147 QLLPPSNSTQWPSV-GRGWRPERFDWITTLGRLRLHGLNGVLLREEVLPRWDDSRNYSIYVNKPS 210

  Fly   212 -------------ELGFD--------HIIVHE-ENISRNTTRAFRLNE-----ERMHGYLRAFGL 249
                         ||..|        :.:..: ::..|...|...|.:     |...|||.:: |
  Fly   211 RQETQPMGEGAMIELLLDIGQTKRTANALARQVDDFERKLHRLQELEDDEGPREMQLGYLDSY-L 274

  Fly   250 PEDRIREAIAGVFAFWRDALEIPPQCEVFDPYRIKRVFPQSEYYYNISWSGLHSTNKLFCDFYYV 314
            |:.|           |   |....|..:.....::.........|..:.|.|..:.
  Fly   275 PQLR-----------W---LSFMRQVRIDSELDLRSTLIIENIPYLRALSDLMESE--------- 316

  Fly   315 ELDKVCARHRKAVANYLAMKLLYRFDPKLKAPR-YQRNYCSVTLYQSMRFLFNKLYMANNFSEAK 378
            ..|.||        :|:.:|.|...  |.:.|. ..|..|...|.::|. |.:...:...||:.:
  Fly   317 SPDTVC--------SYIMLKWLAFL--KQQGPADISRGECVAALRRAMP-LASSWLVGQQFSDPE 370

  Fly   379 -RLEMSEMVRELRKSLRKALEDADWLDAESRAR----------ALLKESRIQPRIGSFQDDALSD 432
             ...:|.:.:.|:....:.|       ||:|.|          ..|:..|:|  :|.||.:.:.|
  Fly   371 SESYVSSLFQRLKVRFGQIL-------AENRMRLSPPLVHILQQKLRAVRLQ--MGFFQTEEIED 426

  Fly   433 RIIREI-------------NSLKVIEDRYAETNINLQHLVVQINRFSSRHFQELT--------ND 476
              :.:.             |.|.::..| .|.|.:|  |.:.:..|::.....|:        ::
  Fly   427 --VEQYHVRIDLSGHSFYGNQLVLLRQR-VEANHDL--LYINVTNFANSTGSNLSYLSESWEASN 486

  Fly   477 TKPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSS 541
            :.|.           |..|.|.:.|..|:::.||:.|::....:...:||::.|||.||||....
  Fly   487 SSPL-----------YVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGM 540

  Fly   542 YFDGNGHMESLLSEI-SQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALT 605
            .:|..|::...:.|| :.:......:|..           .:...|...:||.:||...||.|..
  Fly   541 DYDAMGNIMGPVEEIGASRQFRQGLQCLQ-----------QQMATGSKWIDEKLADFVALRLAYE 594

  Fly   606 AY------RSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCS-------HYEEEHYWK 657
            .:      |..|..||....|              .||||:.|||.||.       ..:.|.:.|
  Fly   595 TFFGVRDKREPRDPLLPQFSQ--------------RQLFFITFAQFFCGRTPVLSPRSQSEAHLK 645

  Fly   658 GLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
                 |..|:.||:..|:|.|:|...:.|...:.|: .::.||:|
  Fly   646 -----HAADELRVMQTLANFEEFSREFGCDKKAKMQ-ASQRCRIW 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	161/729 (22%)
Nepl5	NP_609022.1	M13	48..682	CDD:341056	161/729 (22%)