Protein Alignment Nepl12 and Nep3

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_523417.2
• Gene: Nep3 / 33005
• FlyBaseID: FBgn0031081
• Length: 786
• Species: Drosophila melanogaster
• Alignment Length: 747
• Identity: 184/747 - (24%)
• Similarity: 302/747 - (40%)
• Gaps: 174/747 - (23%)

  Fly    57 AEFMKSYMNQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDL--- 118
            :|.:|| ::.:|:||::||.|:|..:....|   .|..:|..|  |:..::...||:.|..|
  Fly   113 SEILKS-IDVTVDPCDDFYGYSCNQWIKNNP---IPEGKSTWG--TFGKLEQMNQLIIRNVLEKP 171

  Fly   119 AEALNVSSELAVAQRFYNACLGANLH-------PFNAADPAYLSLIRSIGGFPAVDGDAWKASN- 175
            |::....:| ..|:.:|.:||.|:.|       |.|       .|:..|||: .|....:..:|
  Fly   172 AKSFKSDAE-RKAKVYYESCLDADEHMEKLGAKPMN-------DLLLQIGGW-NVTKSGYNVANW 227

  Fly   176 ------------------FNWI------NMSAHLANYGANGLIRETLQLRYPFEPYTKLPELGFD 216
                              |.|.      |.|.|:......||...|..
  Fly   228 TMGHTLKILHNKYNFNCLFGWAIGEDDKNSSRHVIQIDQGGLTLPTAD----------------- 275

  Fly   217 HIIVHEENISRNTTRAFRLNE--ERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCE--- 276
                :..|.:.|..:.  |||  |.|.......|..|...|..:.||..|.:....|....|
  Fly   276 ----YYNNKTDNHRKV--LNEYIEYMTKVCVLLGANESDARAQMIGVINFEKKLANITIPLEDRR 334

  Fly   277 ----VFDPYRIKRVFPQSEYYYNISWSGLHSTNKL---------------FCDFYYVELDKVCAR 322
                ::.|.:::::...:.:   ::|:. |..|.:               :...:...|..:..:
  Fly   335 NEEAMYHPMQLRQLSKLAPF---LNWTD-HFDNAMQMVGRRVTDDEVVVVYAPDFLKNLSDIILK 395

  Fly   323 HRK------AVANYLAMKLLYRFDPKLKAP---RYQR---------------NYCSVTLYQSMRF 363
            ..:      .:.|||..:.:......|..|   .|:.               .||.......:.|
  Fly   396 MEQTEEGKITLNNYLVWQAVRTLTSCLSKPFRDAYKGVRKALMGSDGGEEIWRYCVSDTNNVVGF 460

  Fly   364 LFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDD 428
            ....:::...|....:....:|:.|:|::.:..|::..|:|.::|.:|:.|.::|...|| |.|.
  Fly   461 AVGAIFVRQAFHGESKPAAEQMIAEIREAFKMNLQNLTWVDKQTREKAIEKANQISDMIG-FPDY 524

  Fly   429 ALS----DRIIREINSLKVIEDRYAETNI---------NLQHLVVQINRFSSRHFQELTN-DTKP 479
            .|.    |:...|:|   :..:.|.|.||         ||:.|...:|:         || ...|
  Fly   525 ILDPVELDKKYAELN---ITPNAYFENNIQVAIYNLKSNLKRLDQPVNK---------TNWGMTP 577

  Fly   480 QKILTGLQVGAGYYTP-DNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYF 543
            |.:       ..|||| .|.|...||:::.|.:..:.|.||.||.:|.::||||.|.||.....:
  Fly   578 QTV-------NAYYTPTKNQIVFPAGILQTPFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREY 635

  Fly   544 DGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYR 608
            |..|::.......|.:...:::||....|..|::.  .|.:|||.||.||||||.||:.|..||:
  Fly   636 DKFGNINRWWDSKSIERFNEKSECIARQYSGYKMN--GRTLNGKQTLGENIADNGGLKAAYHAYQ 698

  Fly   609 SHRQQLLEHPGQERISD--AMPGLDLTPEQLFFLGFAQLFCSH-YEEEHYWKGLSDVHTFDQFRV 670
            ..:        .:|..|  .:|||:||..||||:.|||::||. .:|.:..:...|.|:..||||
  Fly   699 RTK--------SDRDVDILKLPGLNLTHSQLFFVSFAQVWCSSTTDETNLLQMEKDPHSPSQFRV 755

  Fly   671 LGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            :|.|||.::|...:.|..|..|.|..| |.:|
  Fly   756 IGTLSNMKEFAEVFQCKPGKRMNPTEK-CEVW 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	179/732 (24%)
Nep3	NP_523417.2	M13	123..784	CDD:341056	179/732 (24%)