Protein Alignment Nepl12 and Nep6

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_572831.2
• Gene: Nep6 / 32234
• FlyBaseID: FBgn0030425
• Length: 655
• Species: Drosophila melanogaster
• Alignment Length: 769
• Identity: 171/769 - (22%)
• Similarity: 293/769 - (38%)
• Gaps: 196/769 - (25%)

  Fly     7 KLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEPC 71
            :|:.::.:.::..|...||:.:  :|...:::                             |:||
  Fly    10 RLVVILGVMLLKLAAAQDCQQQ--LDNDTDAE-----------------------------VKPC 43

  Fly    72 ENFYEYACGNYRNVKPDRYSPGSRSNLG----------DVTYTLIDITEQLLGRMDLAEALNVSS 126
            |||::|||||:       ||..|:..||          ::...||...|:.......:...:|::
  Fly    44 ENFHQYACGNW-------YSNTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTT 101

  Fly   127 ELAVAQRFYNACL--GANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANYG 189
            ..|.....|..||  |.::..:..|      |.||...||.:....  ..:|:|:..:|.|..||
  Fly   102 STAQLGTLYRCCLLSGQSIRTYTDA------LSRSGANFPLLANHT--GGSFDWVLANAALRTYG 158

  Fly   190 ANG----LIRETLQ-----LRYPFEPYTKLPELGFDHIIVHEENISRNTTRAFRLNEERMHGYLR 245
            |.|    |:::..|     :.|...|  |...||.|.                .|||.....||:
  Fly   159 AQGLWRLLVKDNWQSADQRIFYMLPP--KFDLLGRDD----------------ELNEFLYQRYLK 205

  Fly   246 ----AFGLPEDRIREA--IAGVFAFWRDALE--IPPQCE----VFDPYRIKRV---FPQSEY--Y 293
                ..||   |:|.|  :|.....:..:|:  :|...|    :..|..:|.:   .|:.|.  |
  Fly   206 ILLLELGL---RVRRAALLAEKLVAFEKSLQKLLPNDAEQTLVLRKPQSLKDLESQLPRLELKRY 267

  Fly   294 YNISWSGLHSTNK---LFCDFYYVE-LDKVCARHRK---AVANYLAMKLLYRF------DPKLKA 345
            :.....|:...:|   |..|..|:: |.::.|.|..   .::.:|.::|...|      |.||
  Fly   268 FETILEGIDWDSKTLLLVADLDYLQGLQRLLAEHTSDPMVLSTWLLLQLPAYFELRLHDDDKL-- 330

  Fly   346 PRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRAR 410
             ..|||:|...|.:.|.....:|.|.....|:.:......::::....|         |.:.:..
  Fly   331 -GNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLFR---------DLKQQFE 385

  Fly   411 ALLKESRIQPRIGSFQDDALSDRIIRE-INSLKVIEDRYAET------------NINLQHLVVQI 462
            .:|.|:.:      |.:|.::..:.|: :.:::::..|..:.            |.:...|.:.:
  Fly   386 LVLNETEV------FNEDLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGNCDANLLQLSL 444

  Fly   463 NRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLP------ISLKF 521
            :: :...::::..:.........|.|.|.|....|.|.:..|::..|:.|:...      ..|..
  Fly   445 SQ-AKLEYRQVFGEPVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSA 508

  Fly   522 GTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALED---RAECYMDYYGKYQVPEISRR 583
            | ||:|:.||::|.||.....:|..|.:.:  .:.|.:|:..   ||.||:..          |.
  Fly   509 G-LGYILAHEMVHAFDLDGLNYDATGQLAN--GQWSARAIIRFGLRAGCYLGV----------RY 560

  Fly   584 VNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCS 648
            .|...|::|||||..|||.||..|| ||.                  ..|..:.||:.|||.:|.
  Fly   561 SNATLTVNENIADTEGLRLALDTYR-HRS------------------GATNLRTFFVAFAQNWCG 606

  Fly   649 HYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            .....   .|||. |.....||..|:.|..:|...:.|...|.|.|..| |.:|
  Fly   607 TVAST---SGLSQ-HAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNK-CHIW 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	164/704 (23%)
Nep6	NP_572831.2	M13	40..653	CDD:341056	164/704 (23%)