Protein Alignment Nepl12 and Nep1

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_511056.2
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Alignment Length: 783
• Identity: 200/783 - (25%)
• Similarity: 335/783 - (42%)
• Gaps: 157/783 - (20%)

  Fly    14 LWVIVAAVLTDCEARSLVDRSENSD-SNGSSTNRSAAEYQLQE----------YAEFMKSYMNQS 67
            |.:..|:|...|....|  ..:|.| .||.....|.:.::.|:          .|..:.|.|:.:
  Fly   130 LAIYFASVHQRCHLYRL--EPDNDDRPNGRWNQDSGSAHEGQDNICMTQECVRTAASLLSAMDLN 192

  Fly    68 VEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAV-- 130
            .:|||:|::||||.:..:.|   .|..||::.  |:.::...:|::.|..|.|.::.....|.
  Fly   193 SDPCEDFFQYACGTWNKMHP---IPEDRSSIS--TFEVLSDQQQVILRAVLEEPIDERDNKATIK 252

  Fly   131 AQRFYNACLGANLHPFNAADPAYL-SLIRSIGGFPAVDGDAWKASNFNW---------------- 178
            |:.|:.:|:  ::..........| .:::|:||:|.::.        ||
  Fly   253 AKTFFKSCM--DIPQIRKIGTGRLKQVLQSLGGWPVIER--------NWSPPADLSVERLMGQLR 307

  Fly   179 INMS----------AHLANYGANGLIRETLQLRYPFEPYTKLPELGFDHIIVHEENISRNTTRAF 233
            :|.|          |...|...|.|..:.||...|...|             :.:..|.|..||:
  Fly   308 LNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDY-------------YLKESSANDRRAY 359

  Fly   234 RLNEERMHGYLRAFGL-----PEDRIREAIAGVFAFWRDALEIP-PQCEVFDP---YRIKRVFPQ 289
                   |.|:....|     |.....| :..|..|....:.:. |:.:..|.   || |.:.|:
  Fly   360 -------HRYMTQVALLLGADPATAAAE-LEKVVLFETQLVNVSLPEADRHDTSLVYR-KMLLPE 415

  Fly   290 -SEYYYNISWS----------------------GLHSTNKLFCDFYYVELDKVCAR-HRKAVANY 330
             .|....:.|.                      |||         |..|:.|:.|. .|:.|.||
  Fly   416 LQELVPEVQWQEYLQAALGPGIPLQEDEPLVTYGLH---------YLTEMGKILAHTDRRVVHNY 471

  Fly   331 LAMKLLYRFDPKLKAPRYQR-------------------NYCSVTLYQSMRFLFNKLYMANNFSE 376
            :..:|:......: ...|||                   :.|.....:.:......|::.:||::
  Fly   472 MLWRLVMSLMSHM-IDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQ 535

  Fly   377 AKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREINSL 441
            ..:....||:..:|.:..:.|.:.||:|.|:||.|..|...:..|||..:....:..:.:|..:|
  Fly   536 ESKEVALEMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNL 600

  Fly   442 KVIEDRYAETNINLQHLVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPD-NSINVMAGV 505
            .::.|.:....:::      :...|.:..:.|......:|..|...|...:|.|: |.|...||:
  Fly   601 TIVPDNFINNVLSI------LQWESEKMLRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGI 659

  Fly   506 VEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMD 570
            ::|..|.:|.|.||.:|.:|.::|||:.||||.....||..|:|....:..:.:|..:|.:|.:|
  Fly   660 LQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVID 724

  Fly   571 YYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPE 635
            .|.:|::.|:...::|:.|..||||||.||:||..||:  :.:.|.  |:|:   .:|||::|.:
  Fly   725 QYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYK--KWETLH--GREQ---QLPGLNMTHD 782

  Fly   636 QLFFLGFAQLFC-SHYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTC 699
            |||||.:||::| |...|:...|..|.||:....||||.||||.||..||.|.:||.|.| |:.|
  Fly   783 QLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNP-AEKC 846

  Fly   700 RLW 702
            .:|
  Fly   847 SVW 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	184/714 (26%)
Nep1	NP_511056.2	M13	194..847	CDD:341056	184/713 (26%)