Protein Alignment Nepl12 and frma

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Alignment Length: 735
• Identity: 164/735 - (22%)
• Similarity: 266/735 - (36%)
• Gaps: 234/735 - (31%)

  Fly    60 MKSYMNQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMD------L 118
            :||:  ...:||:|||:.||||:           |.|:..| :|      |..:.|:|      |
  Fly    19 VKSH--PQADPCQNFYKVACGNW-----------SASHATD-SY------ESFMDRLDYNYQEKL 63

  Fly   119 AEALNVSSE------LAVAQRFYNACLGANLHPFNAADP----AYLSLIRSIG------GFPAV- 166
            |:.|:...|      |...:.||.||    ..|.:....    .:|.::.:|.      |..|.
  Fly    64 ADLLDNEREDDEPHFLQQLRNFYTAC----RKPLSQDQVLRILEHLIVMENIQNEELSVGLTAAF 124

  Fly   167 ---------DGDAWKASNFNWINMSAHLANYGANGLIRETL-------------QLRYPFEPY-- 207
                     |.:.:..    |..:.:|..::..|...||.|             ::.:||:.|
  Fly   125 RLQVLIDLNDSNTYDI----WKQLMSHRKHWDPNTTNREPLTREMFDKLWASLPKIPFPFKEYYW 185

  Fly   208 TKLPELGFDHIIVHEENISRNTTRAFRLNEERMHGYLRAFGLPEDRI--REAIAGVFAFWRDALE 270
            .:|.||                       ||::..|    |..:|..  .:.:..:..||.
  Fly   186 RELSEL-----------------------EEKIMSY----GSEDDGFDSGDLVTRIPPFWM---- 219

  Fly   271 IPPQCEVFDPYRIKRVFPQSEY-YYNIS----WSGLHSTNKLFCDFYYVELDKV----------- 319
            :|              :|.... |.|:|    |..: ..|:....:.|:.|..|
  Fly   220 MP--------------WPNGNITYENLSQMAHWLDI-KANEFILTYIYMRLKLVAEGVSTESWHI 269

  Fly   320 ----CARHRKAVANYLAMKLLYRFDPKLK-APRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKR 379
                ||...:.:.::.|..|:.:..|:|| .|..|..:..:......:.|.|:    |||:.:.:
  Fly   270 DRDQCAEQSRQILSHPAAWLVEKNHPRLKEEPVLQDIFAELKQRFGQKLLANR----NNFTRSTQ 330

  Fly   380 LEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREINSLKV- 443
            ..:...::.:|..|                       .|.||..|.|  ::..||.|....:.:
  Fly   331 HFLLGKLKRMRLRL-----------------------SILPRNSSAQ--SMVRRIERHYRDVHMN 370

  Fly   444 IEDRYAETNINLQHLVVQINRFSSRHFQEL---------------TNDTKPQKIL-TGLQVGAGY 492
            ..|.:...:|.|.|     :| |.:.:.:|               .:|..|.::. .|....|.|
  Fly   371 ASDYFGNLHIGLNH-----SR-SHKKYAQLWAIVFGRQLIPSRISKSDLYPTQVRGYGTYASAFY 429

  Fly   493 YTPDNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEIS 557
            ....|.:.|...::|||.|....|..|.:..||||:||||.||||:....|..:|        :.
  Fly   430 IVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFSSHG--------VG 486

  Fly   558 QQALE---DRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPG 619
            ..|::   ||...:....|.     :.||...|..  |..||.|||..|.:||....|  .:|.
  Fly   487 SSAVDRELDRNPRFQQELGC-----LRRRFGRKRY--EKFADASGLELAYSAYFDTAQ--TDHK- 541

  Fly   620 QERISDAMPGLDLTPEQLFFLGFAQLFCSHYE--EEHYWKGLSDVHTFDQFRVLGVLSNSEDFFH 682
            :.|.::.:    :|.:|.||..|||.|||..|  :.|       .|..|:.||...:::.|.|..
  Fly   542 RNRSAEEL----VTQKQQFFHNFAQFFCSDKELLQAH-------DHGSDRKRVNDAVAHFEPFRE 595

  Fly   683 AYNCSVGSGMRPGAKTCRLW 702
            |::|    |..|..:.|||:
  Fly   596 AFSC----GPSPRRRQCRLY 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	159/723 (22%)
frma	NP_572226.2	GluZincin	25..601	CDD:472708	157/715 (22%)