DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl12 and Mmel1

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001101467.2	Gene:	Mmel1 / 313755	RGDID:	1309299	Length:	774	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	214/759 - (28%)
Similarity:	342/759 - (45%)	Gaps:	141/759 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEPCENFYEYACGNY--RNVKPDRY 90
            |.|.|.|:.||...:.:...||...||.        |:||.:||:|||:||||.:  .:|.|:
  Rat    73 RVLRDSSQKSDICTTPSCVIAAARILQN--------MDQSKKPCDNFYQYACGGWLRHHVIPE-- 127

  Fly    91 SPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAV--AQRFYNACLGANLHPFNAADPAY 153
             ..||.::.|:   |.|..|.:|  ..:.|..:|....||  |:..|.:|:..::.....::| .
  Rat   128 -TNSRYSVFDI---LRDELEVIL--KGVLEDSSVQHRPAVEKAKTLYRSCMNQSVIEKRDSEP-L 185

  Fly   154 LSLIRSIGGFP-AVD------GDAWKA--------SNFN---------W---INMSAHLANYGAN 191
            |:::..|||:| |:|      |..|:.        |.||         |   .|.|.|:......
  Rat   186 LNVLDMIGGWPVAMDKWNETMGPKWELERQLAVLNSQFNRRVLIDLFIWNDDQNSSRHVIYIDQP 250

  Fly   192 GL---------------IRET-LQ------------LRYPFEPYTKLPELGFDHIIVHEENISRN 228
            .|               :||. ||            |..|.|......|:.   .::|.|....|
  Rat   251 TLGMPSREYYFKEDSHRVREAYLQFMTSVATMLRRDLNLPGETDLVQEEMA---QVLHLETHLAN 312

  Fly   229 TTRAFRLNEERMHGYLRAF---GLPEDRIREAIAGV--FAFWRDAL-----EIPPQCEVF---DP 280
            .|    :.:|:.|.....:   ||.|.:.|..:.|.  ..|.::.|     |:.|..||.   .|
  Rat   313 AT----VPQEKRHDVTALYHRMGLEELQERFGLKGFNWTLFIQNVLSSVQVELLPNEEVVVYGIP 373

  Fly   281 Y-----RIKRVFPQSEYYYNISWSGLHSTNKLFCDFYYVELDKVCARHRKAVANYLAMKLLYRFD 340
            |     .|..|||.......:.|       :|..|    .:..:..|.::|..:|  .|.||  .
  Rat   374 YLENLEEIIDVFPAQTLQNYLVW-------RLVLD----RIGSLSQRFKEARVDY--RKALY--G 423

  Fly   341 PKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDA 405
            ..::..|::.  |...:..:|......||:...||:..:..:||::.::|......|::.:|:|.
  Rat   424 TTMEEVRWRE--CVSYVNSNMESAVGSLYIKRAFSKDSKSIVSELIEKIRSVFVDNLDELNWMDE 486

  Fly   406 ESRARALLKESRIQPRIGSFQDDALSD---RIIREINSLKVIEDRYAETNINLQHLVVQINRFSS 467
            ||:.:|..|...|:.:|| :.|..|.|   .:..|.:||...||.|.|.  .||:|    ...:.
  Rat   487 ESKKKAQEKALNIREQIG-YPDYILEDNNRHLDEEYSSLTFSEDLYFEN--GLQNL----KNNAQ 544

  Fly   468 RHFQELTNDTKPQKILTGLQVGAGYYTPDNSINVM-AGVVEPPIYQRHLPISLKFGTLGFIVGHE 531
            |..::|.........:.|..|...:|:|:.::.|. ||:::||.:.:..|.:|.||.:|.::|||
  Rat   545 RSLKKLREKVDQNLWIIGAAVVNAFYSPNRNLIVFPAGILQPPFFSKDQPQALNFGGIGMVIGHE 609

  Fly   532 LIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKY--QVPEISRRVNGKTTLDENI 594
            :.||||.....||.||:|....|..|.:....:::|.:..|..:  ::.: ::.|||.:||.|||
  Rat   610 ITHGFDDNGRNFDKNGNMLDWWSNFSARHFRQQSQCMIYQYSNFSWELAD-NQNVNGFSTLGENI 673

  Fly   595 ADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGL 659
            |||.|:||   ||:::.|.|.|....:|    :|||:||..||||:.:||::|..|..|...:.:
  Rat   674 ADNGGVRQ---AYKAYLQWLAEGGRDQR----LPGLNLTYAQLFFINYAQVWCGSYRPEFAIQSI 731

  Fly   660 -SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
             :|||:..::||||.|.|...|..|::|..||.|.| ...||:|
  Rat   732 KTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHP-MNRCRIW 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	198/715 (28%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21
Mmel1	NP_001101467.2	M13	106..772	CDD:341056	198/714 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344524
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850