DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl12 and Kel

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001178540.1	Gene:	Kel / 297025	RGDID:	1565470	Length:	713	Species:	Rattus norvegicus

Alignment Length:	783	Identity:	168/783 - (21%)
Similarity:	304/783 - (38%)	Gaps:	196/783 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYM---NQSVE 69
            ||...:|||.   :..:|               |..|..|..      ..|.:..|:   |:|..
  Rat    39 LIGCSMLWVY---IFRNC---------------GPWTCESPV------CMELVNHYLASGNRSAA 79

  Fly    70 PCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAVAQRF 134
            ||.:|:.:|| ...|...:.:...:..|           ..:|...::...:.::.|....|.:|
  Rat    80 PCTDFFSFAC-EKANGTSNSFQALAEEN-----------KSRLWKLLEAPGSWHLESGEEKAFQF 132

  Fly   135 YNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANYGANGLIRETLQ 199
            ||:|:..:....:...| .:.:|:.:||: .:.|: |...:||. |:...::.||.....|..|.
  Rat   133 YNSCMDTDAIEASGTGP-LVQIIKELGGW-NISGN-WTFFDFNQ-NLRLLMSQYGHFPFFRAYLH 193

  Fly   200 LRYPFEPYTKL-----PELGFDHIIVHEENISRNTTRAFRLNEERMHG--------YLRAFGL-- 249
             .:|..|:|.:     ||  ||.::..::             |::::.        ||...|.
  Rat   194 -PHPAPPHTPIIQIDQPE--FDILLQQDQ-------------EQKVYAQILREYVTYLNRLGTLL 242

  Fly   250 ---PEDRIREA------IAGVFAFWRDALEIPPQCEVFDPYRIKRVFPQSEYYYNISWSGLHSTN 305
               |::..:.|      .:.:|.|.|...:...|.::|....|..:   .|....|.|  |....
  Rat   243 GSNPQEAQQHASWSIVFTSRLFQFLRPQQQQQAQDKLFHVVTIDAL---QEMAPAIDW--LSCLQ 302

  Fly   306 KLFC-------------DFYYVE-----LDKVCARHRKAVANYLAMKLLYRFDPKLKAPRYQRNY 352
            .:|.             |..|:.     :::....|.:.:.:|:.:.|:....|.| |.::|...
  Rat   303 AIFTPMSLSPSQTLQVHDLDYLRNMSQLVEEGLLNHSEIIQSYMILGLVDTLSPAL-ATKFQEAR 366

  Fly   353 CSVTLYQSMRFLFNK--------------------------LYMANNFSEAKRLEMSEMVRELRK 391
            ..:|  |.:|.|..:                          |::...|..:.|....|:..|::.
  Rat   367 RELT--QKLRKLKERPPLPAYPRWMKCVEQTGSFFEPTLAALFVHEAFGPSIRSAAMELFAEIKD 429

  Fly   392 SLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREINSLKVIEDRYAETNINLQ 456
            ::...|:...|:..|:|..||.|.:::|..:|:      ..|.::    .::.:..|::
  Rat   430 AVIVRLKKLSWISEETRKEALNKLTQLQVEMGA------PKRALK----TEMAKQEYSD------ 478

  Fly   457 HLVVQINRFSSRHFQELTNDTKPQKILTGLQ-------------VGAGYYTPDNSINVMAGVVEP 508
               :|:.....:.|.......:.:|:.:.||             |.|.|..||:.:...||:::|
  Rat   479 ---IQLGPSFLQSFLSCVRSLQGRKVRSFLQPFPYHRWQKSPWSVSAYYSVPDHVVVFPAGLLQP 540

  Fly   509 PIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLL----SEISQQALEDRAECYM 569
            |.:....|.::.||.:|.|:.|:|:|.|            .:.||    .....:||::...|..
  Rat   541 PFFHPGYPRAVNFGAVGSIMAHKLLHIF------------FQFLLPGGCPACDTRALQEALLCLE 593

  Fly   570 DYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTP 634
            ..|..:.:|.:| ..||..||.||.||..|:..|..||   |:::.|..|:.    .:|..:|:|
  Rat   594 HRYAAFPLPSMS-SFNGSHTLLENAADIGGVAIAFQAY---RKRITERTGEL----TLPNQELSP 650

  Fly   635 EQLFFLGFAQLFCSHYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTC 699
            .||||..:||:.|    .|...:...|.|:..:.||.|.||||.||...:.|..||.:.|..: |
  Rat   651 YQLFFRSYAQVMC----RELISQDPQDTHSPPRLRVHGPLSNSPDFAKHFLCPSGSLLNPSTR-C 710

  Fly   700 RLW 702
            :||
  Rat   711 KLW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	152/716 (21%)
Kel	NP_001178540.1	PepO	75..713	CDD:226118	155/721 (21%)
Kel	NP_001178540.1	M13	78..711	CDD:189000	152/716 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.810