Protein Alignment Nepl12 and Mmel1

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_038811.2
• Gene: Mmel1 / 27390
• MGIID: 1351603
• Length: 766
• Species: Mus musculus
• Alignment Length: 776
• Identity: 202/776 - (26%)
• Similarity: 337/776 - (43%)
• Gaps: 174/776 - (22%)

  Fly    28 RSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEPCENFYEYACGNY--RNVKPDRY 90
            |:|.|.|..||...:.:...||...|:.        |:||..||||||:||||.:  .:|.|:..
Mouse    64 RALRDSSLKSDICTTPSCVIAAARILEN--------MDQSRNPCENFYQYACGGWLRHHVIPETN 120

  Fly    91 SPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSE-----LAVAQRFYNACLGANLHPFNAAD 150
            |          .|::.||....| .:.|...|..|:.     :..|:..|.:|:..::.....::
Mouse   121 S----------RYSVFDILRDEL-EVILKGVLEDSTSQHRPAVEKAKTLYRSCMNQSVIEKRDSE 174

  Fly   151 PAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANYGANGLIRETLQLRYPFEPYTKLPELGF 215
            | .||:::.:||:| |..|.|                       .||:.|::..|....:....|
Mouse   175 P-LLSVLKMVGGWP-VAMDKW-----------------------NETMGLKWELERQLAVLNSQF 214

  Fly   216 DHIIV-------HEENISRNT-----------TRAFRLNEERMHGYLRAF---------GLPEDR 253
            :..::       .::|.||:.           :|.:...|:..|...:|:         .|.:|:
Mouse   215 NRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSREYYFQEDNNHKVRKAYLEFMTSVATMLRKDQ 279

  Fly   254 --------IREAIAGVFAFWRDALEIP--------PQ---------------CEVFDPYRIK--- 284
                    :||.:|       :.||:.        ||               .|:.:.:.:|
Mouse   280 NLSKESAMVREEMA-------EVLELETHLANATVPQEKRHDVTALYHRMDLMELQERFGLKGFN 337

  Fly   285 --------------RVFPQSE-------YYYNI-----SWSGLHSTNKLFCDFYYVELDKVCARH 323
                          .:||..|       |..|:     |:|.....|.|........:..:..|.
Mouse   338 WTLFIQNVLSSVEVELFPDEEVVVYGIPYLENLEDIIDSYSARTMQNYLVWRLVLDRIGSLSQRF 402

  Fly   324 RKAVANYLAMKLLYRFDPKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRE 388
            ::|..:|  .|.||  ...::..|::.  |...:..:|......||:...||:..:..:.|::.:
Mouse   403 KEARVDY--RKALY--GTTVEEVRWRE--CVSYVNSNMESAVGSLYIKRAFSKDSKSTVRELIEK 461

  Fly   389 LRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSD---RIIREINSLKVIEDRYAE 450
            :|......|::.:|:|.||:.:|..|...|:.:|| :.|..|.|   .:..|.:||...||.|.|
Mouse   462 IRSVFVDNLDELNWMDEESKKKAQEKAMNIREQIG-YPDYILEDNNKHLDEEYSSLTFYEDLYFE 525

  Fly   451 TNINLQHLVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPD-NSINVMAGVVEPPIYQRH 514
            .  .||:|    ...:.|..::|.........:.|..|...:|:|: |.|...||:::||.:.:.
Mouse   526 N--GLQNL----KNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKD 584

  Fly   515 LPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKY--QV 577
            .|.||.||.:|.::|||:.||||.....||.||:|....|..|.:..:.:::|.:..||.:  ::
Mouse   585 QPQSLNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFQQQSQCMIYQYGNFSWEL 649

  Fly   578 PEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGF 642
            .: ::.|||.:||.||||||.|:|||..||    .:.|...|:::   .:|||:||..||||:.:
Mouse   650 AD-NQNVNGFSTLGENIADNGGVRQAYKAY----LRWLADGGKDQ---RLPGLNLTYAQLFFINY 706

  Fly   643 AQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ||::|..|..|...:.: :|||:..::||||.|.|...|..|::|..||.|.| .|.||:|
Mouse   707 AQVWCGSYRPEFAVQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHP-MKRCRIW 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	187/732 (26%)
Mmel1	NP_038811.2	M13	97..764	CDD:341056	187/731 (26%)