DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl12 and Mmel1

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_038811.2	Gene:	Mmel1 / 27390	MGIID:	1351603	Length:	766	Species:	Mus musculus

Alignment Length:	776	Identity:	203/776 - (26%)
Similarity:	336/776 - (43%)	Gaps:	174/776 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEPCENFYEYACGNY--RNVKPDRY 90
            |:|.|.|..||...:.:...||...|:.        |:||..||||||:||||.:  .:|.|:..
Mouse    64 RALRDSSLKSDICTTPSCVIAAARILEN--------MDQSRNPCENFYQYACGGWLRHHVIPETN 120

  Fly    91 SPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSE-----LAVAQRFYNACLGANLHPFNAAD 150
            |          .|::.||....| .:.|...|..|:.     :..|:..|.:|:..::.....::
Mouse   121 S----------RYSVFDILRDEL-EVILKGVLEDSTSQHRPAVEKAKTLYRSCMNQSVIEKRDSE 174

  Fly   151 PAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANYGANGLIRETLQLRYPFEPYTKLPELGF 215
            | .||:::.:||:| |..|.|                       .||:.|::..|....:....|
Mouse   175 P-LLSVLKMVGGWP-VAMDKW-----------------------NETMGLKWELERQLAVLNSQF 214

  Fly   216 DHIIV-------HEENISRNT-----------TRAFRLNEERMHGYLRAF---------GLPEDR 253
            :..::       .::|.||:.           :|.:...|:..|...:|:         .|.:|:
Mouse   215 NRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSREYYFQEDNNHKVRKAYLEFMTSVATMLRKDQ 279

  Fly   254 --------IREAIAGVFAFWRDALEIP--------PQ---------------CEVFDPYRIK--- 284
                    :||.:|       :.||:.        ||               .|:.:.:.:|
Mouse   280 NLSKESAMVREEMA-------EVLELETHLANATVPQEKRHDVTALYHRMDLMELQERFGLKGFN 337

  Fly   285 --------------RVFPQSE-------YYYNI-----SWSGLHSTNKLFCDFYYVELDKVCARH 323
                          .:||..|       |..|:     |:|.....|.|........:..:..|.
Mouse   338 WTLFIQNVLSSVEVELFPDEEVVVYGIPYLENLEDIIDSYSARTMQNYLVWRLVLDRIGSLSQRF 402

  Fly   324 RKAVANYLAMKLLYRFDPKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRE 388
            ::|..:|  .|.||  ...::..|::.  |...:..:|......||:...||:..:..:.|::.:
Mouse   403 KEARVDY--RKALY--GTTVEEVRWRE--CVSYVNSNMESAVGSLYIKRAFSKDSKSTVRELIEK 461

  Fly   389 LRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSD---RIIREINSLKVIEDRYAE 450
            :|......|::.:|:|.||:.:|..|...|:.:|| :.|..|.|   .:..|.:||...||.|.|
Mouse   462 IRSVFVDNLDELNWMDEESKKKAQEKAMNIREQIG-YPDYILEDNNKHLDEEYSSLTFYEDLYFE 525

  Fly   451 TNINLQHLVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPD-NSINVMAGVVEPPIYQRH 514
            .  .||:|    ...:.|..::|.........:.|..|...:|:|: |.|...||:::||.:.:.
Mouse   526 N--GLQNL----KNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKD 584

  Fly   515 LPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPE 579
            .|.||.||.:|.::|||:.||||.....||.||:|....|..|.:..:.:::|.:..||.:.. |
Mouse   585 QPQSLNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFQQQSQCMIYQYGNFSW-E 648

  Fly   580 I--SRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGF 642
            :  ::.|||.:||.||||||.|:|||..||    .:.|...|:::   .:|||:||..||||:.:
Mouse   649 LADNQNVNGFSTLGENIADNGGVRQAYKAY----LRWLADGGKDQ---RLPGLNLTYAQLFFINY 706

  Fly   643 AQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ||::|..|..|...:.: :|||:..::||||.|.|...|..|::|..||.|.| .|.||:|
Mouse   707 AQVWCGSYRPEFAVQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHP-MKRCRIW 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	188/732 (26%)
Mmel1	NP_038811.2	PepO	89..766	CDD:226118	194/749 (26%)
Mmel1	NP_038811.2	M13	97..764	CDD:189000	188/731 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841116
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950