Protein Alignment Nepl12 and Mme

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_036740.1
• Gene: Mme / 24590
• RGDID: 3098
• Length: 750
• Species: Rattus norvegicus
• Alignment Length: 800
• Identity: 191/800 - (23%)
• Similarity: 329/800 - (41%)
• Gaps: 181/800 - (22%)

  Fly     6 LKLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEP 70
            :.|..|:||..|:|..:.     :|....::.....|...:|||.         :...|:.|.||
  Rat    29 ISLSVLVLLLTIIAVTMI-----ALYATYDDGICKSSDCIKSAAR---------LIQNMDASAEP 79

  Fly    71 CENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAV--A 131
            |.:|::||||.:  |||.|:..|..|..::      |.|..|.:|  .|:.:.......:||  |
  Rat    80 CTDFFKYACGGWLKRNVIPETSSRYSNFDI------LRDELEVIL--KDVLQEPKTEDIVAVQKA 136

  Fly   132 QRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVD-------GDAWKASNFNWINMSAHLANYG 189
            :..|.:|:..:........| .|:|:..|.|:|...       |.:|.|..    :::...:.||
  Rat   137 KTLYRSCINESAIDSRGGQP-LLTLLPDIYGWPVASQNWEQTYGTSWTAEK----SIAQLNSKYG 196

  Fly   190 ANGLI---------RETLQLRYPFEPYTKLPELGF---------------DHII----------- 219
            ...||         ..|..:.:..:|...||...:               |.:|
  Rat   197 KKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQR 261

  Fly   220 --VHEENISRNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCEVFDPYR 282
              :.|..:|....:...|.:|    ...|...||||                        .||..
  Rat   262 LPIDENQLSLEMNKVMELEKE----IANATTKPEDR------------------------NDPML 298

  Fly   283 IKRVFPQSEYYYN---------ISWSGLHSTNKL----------------FCDFYYVELDKVCAR 322
            :......::...|         .|||..  ||::                :...|..:|..:..:
  Rat   299 LYNKMTLAKLQNNFSLEINGKPFSWSNF--TNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTK 361

  Fly   323 HR-KAVANYLAMKLLYRFDPKLKAPRYQRNY-----------------------CSVTLYQSMRF 363
            :. :.:.|.::.:.:......|     .|||                       |:..:..:|..
  Rat   362 YSPRDLQNLMSWRFIMDLVSSL-----SRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMEN 421

  Fly   364 LFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDD 428
            ...:||:...|:...:..:.:::.::|:...:.|:|..|:|||::.:|..|...|:.||| :.||
  Rat   422 AVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIG-YPDD 485

  Fly   429 ALS--DRIIREINSLKVIEDRYAETNINLQHLVVQINRFS-SRHFQELTNDTKPQKILTGLQVGA 490
            .:|  :::..|...|...|:.|.|.       ::|..:|| |:..::|.......:.::|..|..
  Rat   486 IISNENKLNNEYLELNYKEEEYFEN-------IIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543

  Fly   491 GYYTPD-NSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLS 554
            .:|:.. |.|...||:::||.:......||.:|.:|.::|||:.||||.....|:.:|.:....:
  Rat   544 AFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWT 608

  Fly   555 EISQQALEDRAECYMDYYGKYQVPEI-SRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHP 618
            :.|....:|:::|.:..||.:..... .:.:||..||.||||||.|:.||..||    |..::..
  Rat   609 QQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYRAY----QNYVKKN 669

  Fly   619 GQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFH 682
            |:|::   :|||||..:|||||.|||::|..|..|:....: :|||:...||::|.|.||.:|..
  Rat   670 GEEKL---LPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFAD 731

  Fly   683 AYNCSVGSGMRPGAKTCRLW 702
            |::|...|.|.|..| ||:|
  Rat   732 AFHCRKNSYMNPERK-CRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	175/734 (24%)
Mme	NP_036740.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	174/732 (24%)