Protein Alignment Nepl12 and Kel

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_115929.3
• Gene: Kel / 23925
• MGIID: 1346053
• Length: 713
• Species: Mus musculus
• Alignment Length: 737
• Identity: 173/737 - (23%)
• Similarity: 305/737 - (41%)
• Gaps: 180/737 - (24%)

  Fly    58 EFMKSYM---NQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRM-DL 118
            |.:..|:   |:||.||.:|:.:|| ...|...|.:..               :||:...|: .|
Mouse    65 ELLDHYLASGNRSVAPCTDFFSFAC-EKANGTSDSFQA---------------LTEENKSRLWRL 113

  Fly   119 AEA---LNVSSELAVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWIN 180
            .||   .::.|....|.:|||:|:..:....:.:.| .:.:|..:||: .:.|: |.:.:||. |
Mouse   114 LEAPGSWHLGSGEEKAFQFYNSCMDTDAIEASGSGP-LIQIIEELGGW-NITGN-WTSLDFNQ-N 174

  Fly   181 MSAHLANYGANGLIRETLQLRYPFEPYTKL-----PELGFDHIIVHEENISRNTTRAFRLNEERM 240
            :...::.||.....|..|: .:|..|:|.:     ||  ||.::..|:             |:::
Mouse   175 LRLLMSQYGHFPFFRAYLR-PHPAPPHTPIIQIDQPE--FDILLQQEQ-------------EQKV 223

  Fly   241 HG--------YLRAFGL-----PEDRIREA------IAGVFAFWRDALEIPPQCEVFDPYRIKRV 286
            :.        ||...|.     |::..:.|      .:.:|.|.|...:...|.::|....|..:
Mouse   224 YAQILREYVTYLNRLGTLLGSNPQEAQQHASWSIVFTSRLFQFLRPQQQQQAQDKLFHVVTIDEL 288

  Fly   287 FPQSEYYYNISW----------SGLHSTNKLFC-DFYYVE-----LDKVCARHRKAVANYLAMKL 335
               .|....|.|          ..|:|:..|.. |..|:.     :::....||:::.:|:.:.|
Mouse   289 ---QEMAPAIDWLSCLQAIFTPMSLNSSQTLVVHDLDYLRNMSQLVEEGLLNHRESIQSYMILGL 350

  Fly   336 LYRFDPKLKAPRYQRNYCSVTLYQSMRFLFNK--------------------------LYMANNF 374
            :....|.|.. ::|.  ....|.|.:|.|..:                          |::...|
Mouse   351 VDTLSPALDT-KFQE--ARRELIQELRKLKERPPLPAYPRWMKCVEQTGAFFEPTLAALFVREAF 412

  Fly   375 SEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREIN 439
            ..:.:....|:..|::.::...|:...|:..|::..||.|.:::|..:|:.:.....|...:|.|
Mouse   413 GPSIQSAAMELFAEIKDAVIIRLKKLSWISEETQKEALNKLAQLQVEMGAPKRAVKPDIATQEYN 477

  Fly   440 SLKVIEDRYAETNINLQHLVVQINRFSSRHFQELTNDTKP------QKILTGLQVGAGYYTPDNS 498
            .:::...       .||..:..:....:|:.|..   .:|      ||  :..:|.|.|...|:.
Mouse   478 DIQLGPS-------FLQSFLSCVRSLRARNVQSF---LQPFPYHRWQK--SPWEVNAYYSISDHM 530

  Fly   499 INVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLL--------SE 555
            :...||:::||.:....|.::.||..|.|:.|||:|.|            .:.||        :.
Mouse   531 VVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIF------------YQLLLPGGCPACDTH 583

  Fly   556 ISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQ 620
            :.|:||    .|...:|..:.:|.|| ..||..||.||.||..|:..|..||   .::::||.|:
Mouse   584 VLQEAL----LCLERHYAAFPLPSIS-SFNGSHTLLENAADIGGVAIAFQAY---SKRIVEHTGE 640

  Fly   621 ERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGLS-----DVHTFDQFRVLGVLSNSEDF 680
            .    .:|.|||:|.||||..:||:.|         :|||     |.|:....||.|.|||:.||
Mouse   641 L----TLPNLDLSPYQLFFRSYAQVMC---------RGLSSQDPQDPHSPPSLRVHGPLSNTPDF 692

  Fly   681 FHAYNCSVGSGMRPGAKTCRLW 702
            ...::|..|:.:.|.|: |:||
Mouse   693 AKHFHCPRGTLLNPSAR-CKLW 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	166/720 (23%)
Kel	NP_115929.3	M13	78..711	CDD:341056	166/720 (23%)