Protein Alignment Nepl12 and Ece1

DIOPT Version :9

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001356106.1
• Gene: Ece1 / 230857
• MGIID: 1101357
• Length: 769
• Species: Mus musculus
• Alignment Length: 724
• Identity: 204/724 - (28%)
• Similarity: 314/724 - (43%)
• Gaps: 153/724 - (21%)

  Fly    64 MNQSVEPCENFYEYACGNY--RNVKPDRYSP-GSRSNLGDVTYTLIDITEQLLGRMDLAEALNVS 125
            |:.:|:||::|:.||||.:  .|..||.:|. |:.|||.:....:|   :.||   :.|.| :||
Mouse   114 MDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAVI---KHLL---ENATA-SVS 171

  Fly   126 SELAVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANYGA 190
            .....||.:|.||:.........|.| .:.||..:||: .:.| .|...||
Mouse   172 EAERKAQVYYRACMNETRIEELRAKP-LMELIEKLGGW-NITG-PWAKDNF-------------- 219

  Fly   191 NGLIRETLQL---RYPFEPYTKLPELGFDHIIVHEENISRNT-----------TRAFRL----NE 237
                ::|||:   .|...|:..:      ::....:|.:.|.           :|.:.|    ||
Mouse   220 ----QDTLQVVTAHYRTSPFFSV------YVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENE 274

  Fly   238 ERMHGYLRAF--------GLPEDRIREAIAGVFAF-------------WRD---------ALE-- 270
            :.:.|||...        |..||.||..:..:..|             .||         |.|
Mouse   275 KVLTGYLNYMVQLGKLLGGGDEDAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQ 339

  Fly   271 --------IPPQCEVFDPYRIKRVFP----QSEYYYNISWSGLHSTNKLFCDFYYV--------- 314
                    :|....:|.|..|....|    ..||...:| :.:::|:|...:.|.:
Mouse   340 TLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLRQVS-TLINNTDKCLLNNYMMWNLVRKTSS 403

  Fly   315 ELDKVCARHRKAVANYLAMKLLYRFDPKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKR 379
            .||:   |.:.|...:  |:::|. ..|...||::  :|......::.|....:::...|:|..:
Mouse   404 FLDQ---RFQDADEKF--MEVMYG-TKKTCIPRWK--FCVSDTENNLGFALGPMFVKATFAEDSK 460

  Fly   380 LEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIG---SFQDDALSDRIIREINSL 441
            ...||::.|::|:..::|....|:|.|:|..|..|...|...||   ...|....|::   .|..
Mouse   461 NIASEIIMEIKKAFEESLSTLKWMDEETRRSAKEKADAIYNMIGYPNFIMDPKELDKV---FNDY 522

  Fly   442 KVIEDRYAETNINLQHLVVQINRFSSRHFQELTND------TKPQKILTGLQVGAGYYTP-DNSI 499
            ..:.|.|.|.       .::...||.|    :|.|      .:.|..:|...|.| ||:| .|.|
Mouse   523 TAVPDLYFEN-------AMRFFNFSWR----VTADQLRKAPNRDQWSMTPPMVNA-YYSPTKNEI 575

  Fly   500 NVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDR 564
            ...||:::.|.|.|..|.:|.||.:|.:|||||.|.||.....:|.:|::.......|.:|.:.:
Mouse   576 VFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQ 640

  Fly   565 AECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPG 629
            .||.:..|..|.|.  ...|||:.||.||||||.||:.|..||    |..::..|.|:   .:|.
Mouse   641 TECMVQQYSNYSVN--GEPVNGRHTLGENIADNGGLKAAYRAY----QNWVKKNGAEQ---TLPT 696

  Fly   630 LDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMR 693
            |.||..|||||||||::||....|...:|| :|.|:..:|||:|.||||::|...:.|..||.|.
Mouse   697 LGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMN 761

  Fly   694 PGAKTCRLW 702
            |..| |.:|
Mouse   762 PHHK-CEVW 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	201/716 (28%)
Ece1	NP_001356106.1	M13	118..767	CDD:341056	201/716 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850