Protein Alignment Nepl12 and nep-24

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_503005.3
• Gene: nep-24 / 190993
• WormBaseID: WBGene00013786
• Length: 567
• Species: Caenorhabditis elegans
• Alignment Length: 615
• Identity: 137/615 - (22%)
• Similarity: 241/615 - (39%)
• Gaps: 102/615 - (16%)

  Fly     7 KLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEPC 71
            ||...|||      :|..|.|...:..:..:..|..:|.....      .|..:.:|.:.||:||
 Worm     9 KLPGFMLL------LLLTCTAPLAIGATTPATRNVCNTPACIT------LAHMLHNYHDPSVDPC 61

  Fly    72 ENFYEYACG-NYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAVAQRFY 135
            :||:::||| .:.:...|.|:        ..|.|:.:|.::.|.:.:.:.:   .||.|: :..|
 Worm    62 DNFHQFACGREHEHETEDIYT--------KKTKTINNIMKRFLKKNETSRS---KSENAM-RTLY 114

  Fly   136 NACLGANLHPFNAADPAYLSL---IRSIGGFPAVDGDAWKASNFNWINMSAHLANYGAN--GLIR 195
            .||.....:...:.:.|...:   |:|||.:|.|| |.|..|.|:..:...:|...|..  ||.:
 Worm   115 KACKTLEKNSTASRNKALQDIFQDIQSIGAWPVVD-DKWDESKFDLNDFLVNLVRLGRKNFGLFQ 178

  Fly   196 ETLQLRY-PFEPYTKLPELGFDHIIVHEENISR-NTTRAFRLNEERMHGYLRAF-----GLPEDR 253
               ..|| ....:...||..:.|.:...:.||. ....:.:.|.:::...|..:     .|.:.:
 Worm   179 ---MARYVNVRNFAIGPEAAWRHNVDLGKTISEILKANSVQTNNKKLLDDLAEYVNLEKALSQHK 240

  Fly   254 IREAIAG-VFA----------FWRDALEIPPQCEVFDPYRIKRVFPQSEYYYNISWSGLHSTNKL 307
            ......| :|:          |.|..|      |:..|.: :.:||:   .|.|.:  |.:|:..
 Worm   241 FNTVQPGYIFSERSDFVSSVNFSRLVL------EMMSPDK-RTLFPE---VYQIMY--LTNTSLF 293

  Fly   308 FCDFYYVELDKVCARH--RKAVANYLAMKLLYRFDPKLKAPRY--QRNYCSVTLYQSMRFLFNKL 368
            |.....:|   ...|:  ::|:||||..|.:   |..:....|  ...:|...:...:.....:.
 Worm   294 FGKNNNLE---TIIRNTSKRALANYLIFKFI---DTSIADLTYGSPSAFCEQKVINFLPRAALRA 352

  Fly   369 YMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIG---SFQDDAL 430
            :..|..|:..|.:::::....:..|.|.:...||:..:|:..|:.:.|.:...||   .|.....
 Worm   353 FYRNFISKENRKKITKLTEATQVQLLKIIGATDWMSIKSKKIAMDRVSSMNMVIGYPDYFDPPGK 417

  Fly   431 SDRIIREINSLKVIEDRYAETNINLQHLVVQINRFSSRHFQEL---TNDTKPQKILTGLQVGAGY 492
            .|.:...:| |...:..|.        :|.:||||...  ||:   |.:.....:..||...|.|
 Worm   418 LDGLFEHLN-LSSSDTYYT--------VVRKINRFMRE--QEMDYYTGEVPYYPLFPGLMTNAMY 471

  Fly   493 YTPDNSINVMAGVVEPPIYQRHLP----ISLKFGTLGFIVGHELI-HGFDTTSSYFDGNGHMESL 552
            ...||::.:.|...:.|.:....|    |:....||...:||... |..|..:      |..|..
 Worm   472 NANDNNLMIFAPFFDDPFFDSSFPDYANIAFTSNTLAHEMGHTFSPHLMDIMT------GTTEVW 530

  Fly   553 LSEISQQALEDRAECYMDYYGKYQVPEISR 582
            |:....:..|.|.:|..|.|.:|..||..|
 Worm   531 LTPKETEEYEKRVKCLEDQYTEYDDPEYGR 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	124/554 (22%)
nep-24	NP_503005.3	GluZincin	58..561	CDD:472708	124/554 (22%)