Protein Alignment Nepl12 and ECE1

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Alignment Length: 777
• Identity: 212/777 - (27%)
• Similarity: 332/777 - (42%)
• Gaps: 160/777 - (20%)

  Fly    11 LMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEPCENFY 75
            |::|.|::||.|..|.|...:.....|.|      ...:|..:...:..:.| |:.:|:||.:|:
Human    77 LVVLVVLLAAGLVACLAALGIQYQTRSPS------VCLSEACVSVTSSILSS-MDPTVDPCHDFF 134

  Fly    76 EYACGNY--RNVKPDRYSP-GSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAVAQRFYNA 137
            .||||.:  .|..||.:|. |:.|||.:....:|   :.||..    ...:||.....||.:|.|
Human   135 SYACGGWIKANPVPDGHSRWGTFSNLWEHNQAII---KHLLEN----STASVSEAERKAQVYYRA 192

  Fly   138 CLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANYGANGLIRETLQL-- 200
            |:.........|.| .:.||..:||: .:.| .|...||                  ::|||:
Human   193 CMNETRIEELRAKP-LMELIERLGGW-NITG-PWAKDNF------------------QDTLQVVT 236

  Fly   201 -RYPFEPYTKLPELGFDHIIVHEENISRNT-----------TRAFRL----NEERMHGYLRAF-- 247
             .|...|:..:      ::....:|.:.|.           :|.:.|    ||:.:.|||...
Human   237 AHYRTSPFFSV------YVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQ 295

  Fly   248 ------GLPEDRIREAIAGVFAF-------------WRD---------ALE----------IPPQ 274
                  |..|:.||..:..:..|             .||         |.|          :|..
Human   296 LGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFL 360

  Fly   275 CEVFDPYRIKRVFP----QSEYYYNISWSGLHSTNKLFCDFYYV---------ELDKVCARHRKA 326
            ..:|.|..|....|    ..||...|| :.:::|::...:.|.:         .||:   |.:.|
Human   361 NTIFYPVEINESEPIVVYDKEYLEQIS-TLINTTDRCLLNNYMIWNLVRKTSSFLDQ---RFQDA 421

  Fly   327 VANYLAMKLLYRFDPKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRK 391
            ...:  |:::|. ..|...||::  :|......::.|....:::...|:|..:...:|::.|::|
Human   422 DEKF--MEVMYG-TKKTCLPRWK--FCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKK 481

  Fly   392 SLRKALEDADWLDAESRARALLKESRIQPRIG---SFQDDALSDRIIREINSLKVIEDRYAETNI 453
            :..::|....|:|.|:|..|..|...|...||   ...|....|::   .|....:.|.|.|.
Human   482 AFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKV---FNDYTAVPDLYFEN-- 541

  Fly   454 NLQHLVVQINRFSSRHFQELTND------TKPQKILTGLQVGAGYYTP-DNSINVMAGVVEPPIY 511
                 .::...||.|    :|.|      .:.|..:|...|.| ||:| .|.|...||:::.|.|
Human   542 -----AMRFFNFSWR----VTADQLRKAPNRDQWSMTPPMVNA-YYSPTKNEIVFPAGILQAPFY 596

  Fly   512 QRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQ 576
            .|..|.:|.||.:|.:|||||.|.||.....:|.:|::.......|.:|.:.:.||.::.|..|.
Human   597 TRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYS 661

  Fly   577 VPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLG 641
            |.  ...|||:.||.||||||.||:.|..||    |..::..|.|.   ::|.|.||..||||||
Human   662 VN--GEPVNGRHTLGENIADNGGLKAAYRAY----QNWVKKNGAEH---SLPTLGLTNNQLFFLG 717

  Fly   642 FAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            |||::||....|...:|| :|.|:..:|||:|.||||::|...:.|..||.|.|..| |.:|
Human   718 FAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHK-CEVW 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	197/716 (28%)
ECE1	XP_011539174.1	M13	127..776	CDD:341056	197/716 (28%)