Protein Alignment Nepl12 and nep-20

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001317749.1
• Gene: nep-20 / 188176
• WormBaseID: WBGene00020293
• Length: 834
• Species: Caenorhabditis elegans
• Alignment Length: 750
• Identity: 150/750 - (20%)
• Similarity: 279/750 - (37%)
• Gaps: 171/750 - (22%)

  Fly     8 LISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEPCE 72
            :|.::|.|:::.......|..||.:..                 |....|..:.:|.:.||..|.
 Worm   192 VILIILFWLLLFIGARQDEKPSLCESP-----------------QCITLAFELSAYQDTSVSKCH 239

  Fly    73 NFYEYACGNYRNVKP-DRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAVAQR-FY 135
            |||:..||.|::.:. |::....:..:      :..|..:.|.|.:    .:::|:...|.| .:
 Worm   240 NFYKATCGKYKHHQALDKHRDAKKKEV------VKRIVREFLRRNE----SSITSKFEPAIRLMF 294

  Fly   136 NACLGANLHPFNAADPAYLSL---IRSIGGFPAVDGDAWKASNFNWINMSAHLANYGAN--GLIR 195
            ..|     :.| :.:..||.:   |..||.:|.:..| |....||..:....|...|..  ||.:
 Worm   295 GKC-----NKF-SQNKTYLDIFKDIEKIGPWPVLKSD-WVDVMFNLNDYLLSLVELGFTDFGLFK 352

  Fly   196 -ETLQL---RYP-FEPYTKLPELGFDHIIVHEENISRNTTRAFRLNEERMHGYLRAFGLPEDRIR 255
             |..||   ::| ..|..:......:.||:  |.:..|..:|.|   :::..|||.:...:.::|
 Worm   353 LEFRQLAFGQFPVIAPSEQKQGNQLEKIIL--EILEANGVQADR---QKLSKYLREYSEFKSQLR 412

  Fly   256 E-AIAGVFAFWRDALEIPPQCEVFDPYRIKRV-FPQSEYYYNIS-------------------WS 299
            . ::.|.                    .:|.: :..|....|||                   .|
 Worm   413 HMSLEGT--------------------SVKYIRYNASTLSVNISALVQKMAPMSTSSGLVRRIQS 457

  Fly   300 GLHSTNKLFCDFYYVELDKVCAR-HRKAVANYLAMKLL--YRFDPKLKAPRYQRNYCSVTLYQSM 361
            |:..||.  ..|:...||.:..: |::.:||||....:  ..||....|...:.....:....|:
 Worm   458 GILITNS--SSFFGKNLDAIIQQTHKRTLANYLIFHFIDAVTFDLTSGAKHSEHTLIDLLPRGSL 520

  Fly   362 RFLFNKLYMANNF-SEAKRLEMSEMVRELRKSLRKALEDADWLD------AESRARALLKESRIQ 419
            :.|      :.:| .|..:..|.||.::|:|.:.:.:.:...||      .|...|.|:::
 Worm   521 QVL------SQDFVDEEDQGVMVEMAKDLKKHVVEMISEGSSLDKGHLVFEEKERRKLIRK---- 575

  Fly   420 PRIGSFQDDALSDRIIREINSLKVIEDRYAETNI----NLQHLVVQINRFSSRHFQE-LTNDTKP 479
                      :.|.::.....|:::...:.:.|:    :|..::.::.||.|....| |..|..|
 Worm   576 ----------VQDILVVTKYPLEILNQNFEKLNLTYSDSLHKIIQKLRRFRSEQLIEYLGGDLDP 630

  Fly   480 QKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFD 544
            ..  .|:...|.|....|.:.::|.:::.|.:....|..:....:|||:..||....|:.....|
 Worm   631 TD--KGMWGSAHYEQATNDLIIIAPIIDGPYFDTSYPNYVNIFFMGFIISRELGRSLDSVRIRKD 693

  Fly   545 GNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRS 609
            ..||.|:.|...|.:..::..:|:            .:::.|...|:|.:||:.|...:..|.:.
 Worm   694 EKGHTENWLKSESLKRFDNNVKCW------------RKKITGTRFLNEMLADHVGHEASFMALKK 746

  Fly   610 HRQQLLEHPGQERISDAMPGLD-LTPEQLFFLGFAQLFC-----------SHYEEEHYWKGLSDV 662
            ..:::     ...|.:.:.|.: :|.||:||...|..||           :....:||
 Worm   747 WEKEM-----NGTIVEKIRGYESMTMEQIFFHLQALYFCRPPGGSTGELTAKDARQHY------- 799

  Fly   663 HTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAK 697
                ..||.....|...|..|:.||....|....|
 Worm   800 ----STRVNEAFKNMPQFAKAFGCSSNQNMNSKTK 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	139/689 (20%)
nep-20	NP_001317749.1	PHA02030	<71..139	CDD:222843
		GluZincin	238..832	CDD:472708	138/686 (20%)