Protein Alignment Nepl12 and nep-2

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_494343.2
• Gene: nep-2 / 188090
• WormBaseID: WBGene00020230
• Length: 736
• Species: Caenorhabditis elegans
• Alignment Length: 776
• Identity: 197/776 - (25%)
• Similarity: 336/776 - (43%)
• Gaps: 146/776 - (18%)

  Fly    14 LWVIVAAVL-------TDCEARSLVDRSENSD---SNGSSTNRSAAEYQLQEYAEFMKSYMNQSV 68
            :|.|:|.:|       ........::..::||   |.|..           :.|..:.|.||.||
 Worm    20 IWAIIALILLILFLLVLGAAIYFYINYKDSSDVCLSPGCI-----------KTASVILSSMNSSV 73

  Fly    69 EPCENFYEYACGNYRNVKP---DRYSPGSRSNLG-DVTYTLIDITEQLLGRMDLAEALNV-SSEL 128
            :||::|||:|||.:....|   |..|..:..||| |:.:.|    ::||...|  |..:. :|.:
 Worm    74 DPCDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQDLEFAL----KELLDEND--EPYDYETSAV 132

  Fly   129 AVAQRFYNACLGANLHPFNAAD------PAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLAN 187
            ..|:.|||.||       |.::      ..:..:::|.||:|:: |...|......:..:..:|.
 Worm   133 GKAKYFYNLCL-------NESEILDNWRTTFDEVVKSFGGWPSL-GHQMKPDASIEMLYADMVAK 189

  Fly   188 YGANGLIRETLQLRYPFEPYTKLPELGFDHIIVHEENISRNTTRAFRL---NEERMHGYLRAFG- 248
            :.|:.|.:.|:|      |..|..:   .|:::.::.......|.|.:   ||||| .||:...
 Worm   190 FKADSLFKATVQ------PDDKNSQ---RHVLLIDQPQLNLFARDFYVAAENEERM-AYLQLIRD 244

  Fly   249 ----LPEDRIREAIAGVFAFWRDALEI------PPQCEVFDPYR--------------IKRVFPQ 289
                |..||.|..:        ||.||      .....:.|.:|              ::|..|.
 Worm   245 VLILLDADRTRATL--------DAKEIIDFETALANITMADEHRHDIAELYTKITLGEMRRSLPH 301

  Fly   290 SEY--YYNISWSGLHSTNKLFCDF------------YYVELDKVCARH-RKAVANYLA------- 332
            ..:  ::|..:..||..|.....|            :...||.:..:: .:.:.|||.
 Worm   302 FNWPLFFNRMFKDLHEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQYDNRLIVNYLEWCWFFKT 366

  Fly   333 ---------MKLLYRFDPKLKAPRYQR---NYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEM 385
                     ...:::|...|.....|:   :.|...:...|....:.:|:.|:|....:.::.||
 Worm   367 MLRDLPDPFALTIFKFYKTLNIMNVQKVRWHGCVTRINSLMPMATSAIYVKNHFDHEAKQQVEEM 431

  Fly   386 VRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSD--RIIREINSLKVIEDRY 448
            :..:.:|....|...|||..|::..|..|.:.::.:||  ..|.|:|  .:..|..:.||....|
 Worm   432 ISLIMESFVDLLLSEDWLTKETKQTAKQKVNEMKRKIG--YPDYLNDPAAVNNEYKTFKVYPGHY 494

  Fly   449 AETNINLQHLVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPD-NSINVMAGVVEPPIYQ 512
            .:|..:.      ..::.....:.:|.....::.:.|..:...:|:|: |.|...||:::|..|.
 Worm   495 YQTKFSF------YEQYQRDVLERITEAVDRERWVAGAALVNAFYSPNTNEIIFPAGILQPVFYS 553

  Fly   513 RHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQV 577
            :..|.|:.||.:|.::|||:.||||.....:|..|::.......:....|.:|:|....|..|.:
 Worm   554 KDFPSSMNFGGIGVVIGHEITHGFDDRGRLYDNLGNIRQWWDNATISKFEHKAQCIEKQYSSYVL 618

  Fly   578 PEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGF 642
            .:|:.::|||:|..||||||.||:||..||:.:.::....|       .:||::||.:|||||.:
 Worm   619 DQINMQINGKSTKGENIADNGGLKQAYRAYKKYEKRHSRPP-------RLPGVNLTHDQLFFLNY 676

  Fly   643 AQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ||::|....::...:.| :..|:....||.|.||||.||..||||..||.|.|..| ||:|
 Worm   677 AQIWCGTMNDKEAIRKLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREK-CRVW 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	181/708 (26%)
nep-2	NP_494343.2	M13	73..734	CDD:341056	181/708 (26%)