DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl12 and nep-18

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_494297.1	Gene:	nep-18 / 186911	WormBaseID:	WBGene00019343	Length:	701	Species:	Caenorhabditis elegans

Alignment Length:	741	Identity:	158/741 - (21%)
Similarity:	285/741 - (38%)	Gaps:	176/741 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 MKSYMNQSVEPCENFYEYACGNY-RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALN 123
            :|:|.|.||:|||:|:|:.||.| .:|..|       ::.|.|.|      :|||.::
Worm    39 IKNYQNASVDPCEDFFEHTCGRYSEHVMDD-------NSWGYVQY------KQLLYQV------- 83

  Fly   124 VSSELAVAQR--------------FYNACLGANLHPFNAADPAYLSL---IRSIGGFPAVDGDAW 171
                .|:|::              |..:||...    ...:..:..|   |...||||.:|.: |
Worm    84 ----FAIARKTNKFNSKPNEQLRIFTKSCLDRK----EMDEDTFQDLRNDIEERGGFPMIDPN-W 139

  Fly   172 KASNFNWINMSAHLANYGANGLIRETLQLRYPF---EPYTKL--------------PELGFD--- 216
            ....|:..:|.|...:...|         |..|   |||..:              |...::
Worm   140 NEEKFDLSDMLAKYLSINRN---------RMGFLSVEPYAAIEGNKSVNRLYVSPGPHWVYNWAM 195

  Fly   217 HIIVHEENISRNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWRD-ALEIPPQCEVFDP 280
            .|.:::::::....|..:|....::..:......|....||.....|.:|: ||:.....:..:.
Worm   196 GISIYKDSVAFMLRRLLKLENRELNETIYDKEFAELVQLEANFSTLADYRNLALDNDNMSKSRNL 260

  Fly   281 YRIKRVFPQSEYYYNISWSGLHSTN-----KLF-------CDFYYVELDKVCAR-----HRKAVA 328
            ..:.::.|:.::...:.....|.|:     ||.       ...|:...::..||     .:.|:|
Worm   261 TDLVKMIPEIDWIKILKALARHGTSEEDEEKLLERVTVHGAGEYFFGENRELARIATETPKSALA 325

  Fly   329 NYLAMK-----LLYRFDPKLKAPRY--------QRNYCSVTLYQSMRFLFNKLYMANNFSEAKRL 380
            |||.::     .||.:|.  ..||.        |:::|:..:..     |..:...|.|.|:.:.
Worm   326 NYLVVRQLIDVALYFYDK--DQPRQNKFYNHVDQQSFCATQVAS-----FFPMPSMNVFIESSQF 383

  Fly   381 E------MSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREIN 439
            :      :.||..:::....:...:.::|:.|.|                       :.:||::|
Worm   384 KIENLKVIEEMFVKIKAEYEQIFTENEYLELEIR-----------------------EFLIRKLN 425

  Fly   440 SL--KVIEDRYAETNINLQHLVVQINRFSS-----------RHFQE-----LTNDTKPQKI-LTG 485
            ::  |...|:|.|....|:.:...:|...:           ||:.|     :.:||....: |..
Worm   426 AIDGKFGLDQYTEGKPLLEKMYETLNFLDTDSPWQVYMKMWRHWSEQLVEHIVHDTPLDPVNLKM 490

  Fly   486 LQVGAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHME 550
            ....|.|....|...:....:..|......|.:..:|.||:::|||:.|.||......|.:|..:
Worm   491 FGTHAAYQPYPNHFYINLPYLTYPWMDADFPANTNYGYLGYVIGHEIGHAFDHFHRKLDESGRQQ 555

  Fly   551 SLL---SEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQ 612
            ...   :..|....|.|.:|..|.|..|:.|.....:||.....|...|:.|:|.|...:...::
Worm   556 QYWFTETNSSNTEYELREKCLRDQYSAYKEPGYDFFMNGTHCRYEIAGDHMGIRTAFRVFEKVKK 620

  Fly   613 QLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKG-LSDVHTFDQFRVLGVLSN 676
                   ::|.  .:|||:::.|||||..:|...|..|......:. |:..|..:::||.||:.|
Worm   621 -------EDRF--RLPGLEMSEEQLFFYNYAFRQCDVYNPNKLPRNMLARQHPTNRYRVNGVIQN 676

  Fly   677 SEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ..:|..|:||...|.|.|..| |:|:
Worm   677 IPEFAEAFNCPKNSPMNPEMK-CKLY 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	152/729 (21%)
nep-18	NP_494297.1	PepO	42..692	CDD:226118	152/726 (21%)
nep-18	NP_494297.1	M13	47..699	CDD:189000	152/729 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920