Protein Alignment Nepl12 and Phex

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_035207.1
• Gene: Phex / 18675
• MGIID: 107489
• Length: 749
• Species: Mus musculus
• Alignment Length: 751
• Identity: 197/751 - (26%)
• Similarity: 323/751 - (43%)
• Gaps: 129/751 - (17%)

  Fly    39 SNGSSTNRSAAEYQLQ----EYAEFMKSYMNQSVEPCENFYEYACGNYRNVKP---DRYS----P 92
            |.|..:.::..||.|:    |.|..:.|.:|.||:|||||:.:||..:.:..|   |..|    |
Mouse    41 SQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYP 105

  Fly    93 GSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAVAQRFYNACLGANLHPFNAADPAYLSLI 157
            ..|.|   |...|..:.|:.:.|....||:.      .|:..|::|:.........|.|....|.
Mouse   106 WLRHN---VDLKLKALLEKSVSRRRDTEAVQ------KAKILYSSCMNEKAIEKADAKPLLHILR 161

  Fly   158 RSIGGFPAVDGD-----AWKASNFNWINMSAHLANYGANGLIRETLQLRYPFEPYTKLPELGFDH 217
            .|...:|.::.:     .|....|:.:...|......:|.:.     :|....|..|...   :|
Mouse   162 HSPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVF-----IRLYVSPDDKASN---EH 218

  Fly   218 II----------VHEENISRNTTRA---------FRLN------------EERMHGYLR------ 245
            |:          |.|:.:. |||.|         |.::            |..|...||
Mouse   219 ILKLDQATLSLAVREDFLD-NTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIA 282

  Fly   246 AFGLP-EDRIREAIAGVFAFWRDALEIPPQCEVFD--PYRIKRVFPQSEYYYNISWSGLHSTNKL 307
            ...:| |:|..||:....    :..|:......||  .| ||:|. .:..|.::...|......:
Mouse   283 EIMIPHENRTSEAMYNKM----NISELSAMIPQFDWLGY-IKKVI-DTRLYPHLKDIGPSENVVV 341

  Fly   308 FCDFYYVELDKVC-ARHRKAVANYLAMKLLYRFDPKLKAPRYQRNY------------------- 352
            ....|:.:|.::. |..:|.:||||..:::|...|.| :.|:|..:
Mouse   342 RVPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNL-SRRFQYRWLEFSRVIQGTTTLLPQWDK 405

  Fly   353 CSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALE-DADWLDAESRARALLKES 416
            |...:..::.::..|:::..:|.|.|:..|.|::..:|.:....|| :.:|:||.::.:|..|..
Mouse   406 CVNFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKAR 470

  Fly   417 RIQPRIGSFQDDALSDRIIRE-INSLKVIEDRYAETNINLQHLVVQINRFSSR----HFQELTND 476
            .:..::| :.:..::|..:.| :.::|..|..|....:..:..:.|.:.|..|    ..:..||.
Mouse   471 AVLAKVG-YPEFIMNDTYVNEDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNP 534

  Fly   477 TKPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIY-QRHLPISLKFGTLGFIVGHELIHGFDTTS 540
            |         .|.|.|....|.|...||.::.|.: ....|.||.:|.:|.|||||..||||...
Mouse   535 T---------TVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNG 590

  Fly   541 SYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALT 605
            ..:|.||:::...|..|::..:::.:|.::.|..|...:....|.||.||.||||||.|||:|..
Mouse   591 RKYDKNGNLDPWWSVESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFR 655

  Fly   606 AYR---SHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGLS-DVHTFD 666
            |||   :.|:|.:|.|       .:||:..|..|||||.:|.:.|:.|..|...:.:. ..|:..
Mouse   656 AYRKWINDRRQGVEEP-------LLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPP 713

  Fly   667 QFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ||||.|.:||.|:|..|:||...|.|..||.:||||
Mouse   714 QFRVNGAISNFEEFQKAFNCPRNSTMNRGADSCRLW 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	183/714 (26%)
Phex	NP_035207.1	M13	74..740	CDD:341056	180/707 (25%)