Protein Alignment Nepl12 and nep-8

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001309548.1
• Gene: nep-8 / 184631
• WormBaseID: WBGene00017553
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 732
• Identity: 162/732 - (22%)
• Similarity: 280/732 - (38%)
• Gaps: 153/732 - (20%)

  Fly     9 ISLMLLWVIVAAVL-----------------TDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEY 56
            ::|:||.|.:|.|.                 .|.::::|.|..|....:....|
 Worm    17 VNLLLLIVFLAMVTVHIKVEPVNLDELLSIGNDVDSKNLCDSPECITLSHELLN----------- 70

  Fly    57 AEFMKSYMNQSVEPCENFYEYACGNY--RNVKPDRYSPGS---RSNLGDVTYTLIDITEQLLGRM 116
                  |.:.||:||.:|::::||.:  ::|...|.....   |..:.:..:.:.:.|.:....|
 Worm    71 ------YQDPSVDPCVDFFQHSCGRFHEQSVSESRLQKKKHILRKQIREFLHKIQNSTSKSENLM 129

  Fly   117 ----DLAEALNVSSELAVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFN 177
                |..||...:|     ...|.....|....||.        |:.||.:|.:|.: |..|.|:
 Worm   130 KLVFDKCEASKKTS-----NDNYKISRDAIHDVFND--------IKKIGAWPLLDKN-WDGSKFD 180

  Fly   178 WINMSAHLANYGANGLIRETLQLRYPFE-PYTKL-PELGFDHIIVHEENISRNTTRAFRLNEERM 240
            ...|.::|...||..|....|..|...| .:.:: |.||   .|||      |:|....::|
 Worm   181 LNEMLSNLVKLGATNLGLFQLDFRILTEGKFVRIAPTLG---SIVH------NSTMISMISE--- 233

  Fly   241 HGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCEVFDPYRIKRVFPQSEYYYNISWSGLHSTN 305
              .|.|.|:..               |:.||..:.|.:...::|....||....:||..|:.|.|
 Worm   234 --ILEANGVQP---------------DSEEISKEFEEYSSLQMKLAKYQSSGKLSISLPGVRSIN 281

  Fly   306 ---------------KLFCDFYYV--------------ELDKVC-ARHRKAVANYLAMKLLYRFD 340
                           |:|.....|              .||.:. :...|.:||:|....:....
 Worm   282 FSSLITEMIHPSRVSKIFGKIRVVTSEHPLFFKSNETESLDTIIESTSNKTLANFLIFNYIQSSY 346

  Fly   341 PKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDA 405
            ..:|..|  |..|...:.:.......:::|.|...:..|..:.::..||:|:..:.::|.:.|..
 Worm   347 NIMKGAR--RGNCEDDVRREFPRASLRVFMRNFVDKGNRDGVKKLTEELKKNTLEMIQDTENLAP 409

  Fly   406 ESRARALLKESRIQPRIG---SFQDDALSDRIIREINSLKVIEDRYAETNINLQHLVVQINRFSS 467
            ..:...|.|...|:..||   .|......|         |..|:...::..:...:..::||..|
 Worm   410 PVKESMLKKVEAIKVTIGYPDHFDPPGTLD---------KEFENFDLDSTDSYYRIFQKLNRLRS 465

  Fly   468 RHFQE-LTNDTKPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLP--ISLKFGTLGFIVG 529
            ....| :..:|....|...|:|.|.|....|::.|.|..::.|.:....|  ::|.|.  ||::.
 Worm   466 EQQMEFIAGETPISPIKEVLKVNANYKRSKNALTVFAPFLDDPFFDITYPDYVNLFFS--GFLIA 528

  Fly   530 HELIHGFDTTSSYFDGNGH-MESL-LSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDE 592
            ||:.|..|.....:|.||. |:.: |..:::..  .:.:|.:|.|..|..|...:::||..:::|
 Worm   529 HEIGHSVDANGLGYDENGKPMDGIRLEHVTEYG--KQGQCLVDQYDNYDDPVYGKKMNGTHSINE 591

  Fly   593 NIADNSGLRQALTAYRS-HRQQLLEHPGQERISDAMPGL-DLTPEQLFFLGFAQLFCSHYEEEHY 655
            .|||..|......||:. ...::|          ::.|| |:..:||:|...:.|||...:....
 Worm   592 IIADWVGHEVTWRAYKKMDTSKML----------SLIGLKDINMDQLYFRVQSLLFCRERDTISL 646

  Fly   656 WKGLSDVHTFDQFRVLG 672
            .:.|.||:..|.|||.|
 Worm   647 EETLKDVYPTDNFRVNG 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	149/656 (23%)
nep-8	NP_001309548.1	M13	76..664	CDD:341056	149/656 (23%)