Protein Alignment Nepl12 and nep-6

DIOPT Version :9

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_494537.1
• Gene: nep-6 / 184628
• WormBaseID: WBGene00017550
• Length: 726
• Species: Caenorhabditis elegans
• Alignment Length: 700
• Identity: 170/700 - (24%)
• Similarity: 302/700 - (43%)
• Gaps: 121/700 - (17%)

  Fly    57 AEFMKSYMNQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEA 121
            |:.:.::.:.||:||::||:.|||.|    .:......|....|:      |.::::....|...
 Worm    94 ADQLLNFQDPSVDPCQDFYKAACGKY----SEHEVANRRLQKKDI------IIQRMIKNFLLKNE 148

  Fly   122 LNVSSELAVAQRFYNACLG-ANLHPFNA-ADPAYLSL---IRSIGGFPAVDGDAWKASNFNWINM 181
            .:.|....|.::.|..|.| .|...||| ...|:..|   |:.||.:||.|.: |..:..|...|
 Worm   149 TSESKSENVMRQVYRTCEGLKNEEIFNANMKTAFRELFKDIQKIGSWPAADKN-WDETKLNLNEM 212

  Fly   182 SAHLANYGAN--GLIRETLQLRYPFEPYTKL-PEL--------GFDHIIVH---------EENIS 226
            ..::...|::  ||    .|:|....|:.:: |::        .|..||..         :||:.
 Worm   213 LLNIVKLGSSNFGL----FQIRPTEVPFLEVAPDMARSPKVSANFQQIIFDILEKNGLQPDENVI 273

  Fly   227 RNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQC------EVFDPYR--- 282
            .:....:...||.:..|  |:....::::        |.:...::|...      |:.:|.|
 Worm   274 ADDVEDYITLEETLSQY--AYDYNAEKVQ--------FSKLQAQVPSLKLEKIIEEMMNPNRKKL 328

  Fly   283 -IKRVFPQSEYYYNISWSGLHSTNKLFCDFYYVELDKVC-ARHRKAVANYL-------AMKLLYR 338
             :.:|.|:...:       .||   ||.| ..:.|:|:. :..::.:||||       ||..|..
 Worm   329 LVTKVKPRMVAH-------KHS---LFFD-EKMNLEKLLKSTPKRTLANYLIFYYMDHAMNGLSV 382

  Fly   339 FDPKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWL 403
            .|..:|    :|| |...:.:.:.....::::.|:|.:.....:.||..|.:||..:.|:::.||
 Worm   383 HDNVIK----KRN-CEKLVIEYLPKASLRVFVRNHFEKGNLKIVDEMAEETKKSFIEMLQESTWL 442

  Fly   404 DAESRARALLKESRIQPRIG---SFQDDALSDRIIREINSLKVI-EDRYAETNINLQHLVVQINR 464
            .|:|:..|:||..::...||   .|:.....|::   ..:||:: :|       .|..::.:|.|
 Worm   443 GADSKKNAILKLEKMGKMIGYPKEFEKKGALDKM---FETLKLLPKD-------TLYGILKKIGR 497

  Fly   465 FSSRHFQE----LTNDTKPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTLG 525
            |   |.::    :..:|....:|..|...| :||..|.::.:.|.::.|::....|..:.....|
 Worm   498 F---HMEQGIEFVALETPMDPVLPVLMTNA-FYTDRNHLSFLVGYMDDPLFDATYPKYVNIALTG 558

  Fly   526 FIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTL 590
            .|:.||..|||||.....|.||.:.|.:.....:....:.:|.:|.|.:|..|...:.:||.|||
 Worm   559 NILAHETSHGFDTAGIKRDENGEVRSWMKPEDLKEYGKKTQCLVDQYNEYDDPVFGKNLNGTTTL 623

  Fly   591 DENIADNSGLRQALTAYR---SHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEE 652
            :|.:||..|:..|...:.   |.::|.:.....|.|           ::|:|...|..|||....
 Worm   624 NEMVADMIGVTVAWKVFEKLDSSKEQKVIGFENENI-----------DKLYFRAAALDFCSLPPT 677

  Fly   653 EHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ....:.|:.||....|||.|:.||...|..|:||..||.|.|..: |.::
 Worm   678 TSLVEELTRVHPTGNFRVNGIFSNMPQFATAFNCPEGSPMNPKTR-CSIF 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	167/685 (24%)
nep-6	NP_494537.1	M13	105..724	CDD:189000	167/685 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870