DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl12 and nep-22

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_509528.1	Gene:	nep-22 / 181144	WormBaseID:	WBGene00020788	Length:	798	Species:	Caenorhabditis elegans

Alignment Length:	777	Identity:	167/777 - (21%)
Similarity:	286/777 - (36%)	Gaps:	149/777 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEPCENFYEYACGNY-RNVKPDRYSPGSRSNLGDV 101
            :|...:.|.|.:..|.   |.::.:.::.:|:||::||.:.|..: :|....:.   .||.||..
Worm    56 NSTPGTVNTSPSYTQA---ANYLLNGLDDTVDPCQDFYAFTCNKFLQNTDLQKL---GRSRLGTY 114

  Fly   102 TYTLIDITEQL---LGRMDLAEALNVSSELAVAQRFYNACLGANLHPFNAADPA------YLSLI 157
            ....:|:..::   |.::|:.......:| .:.:..:..|..      |.|.||      |..:.
Worm   115 DQAQVDVYSEIVAALSKIDVTSTTTSKTE-RITKAAFETCKN------NLASPADKTAVVYAEIT 172

  Fly   158 RSIGGFPAVDGDAWKASNFNWINMSAHLANYGANGLIRETLQLRYPFEPYTK------LPELGFD 216
            ...||.|.. |:..|.:...|: ::..:....|.|.:..|: ....::.:||      .|.|...
Worm   173 SLFGGVPFF-GEPLKTNVDYWM-VAGQIEQKHAVGTLTYTI-ASSDYKDHTKNALYTGPPGLSLA 234

  Fly   217 H-IIVHEENISRNTTRAFRLNEERMHGYLRAF------GLPEDRIREAIAGVFAF--------WR 266
            . ..|..:.|:....|...:|:     .|.||      .:..|.:..|...|..|        |.
Worm   235 RDFYVKPQYIAEVNQRVSDVND-----LLTAFANAAKKNVGADALLAAAQEVVNFEVQIAMASWP 294

  Fly   267 DALEIPPQCEVFDPYRIKRVFPQSEYYYNISWSGLHSTNKLFCDF-----------------YYV 314
            |.| :....:.::||.|...   :..|..|:|...  ..:||...                 |:.
Worm   295 DDL-LRNYQQQYNPYNIASA---TTAYRAINWKSY--LGQLFHGVASDADQANYNIVVTEPSYFA 353

  Fly   315 ELDKVC---ARHRKAVANYLAMKLLYR----FDPKLKAPRYQRNY-------------------- 352
            .|:.|.   ..:...||||:..:||..    .:|.........||
Worm   354 WLNSVFDGKTSNSTVVANYMIAQLLADESDFINPATAKVSSDTNYIHYALRNGRGIKKIGKREYR 418

  Fly   353 ----------CSVTLYQSMRFLFNKLYMANNFSEAK-RLEMSEMVRELRKSLRKALEDADWLDAE 406
                      |...|...|.:....:|:.:.....| :.::.:....:..:.:..::..:|:|..
Worm   419 MADLDGISEGCMDLLTAYMPYGTGYVYVKSKSERNKVQADVKDQTTLIINNFQGMIDSLNWMDTF 483

  Fly   407 SRARALLKESRI-------QPRIGSFQDDALSDRIIREINSLKVIEDRYAETNINLQHLVVQINR 464
            |:.||..|...:       :...|.|.|....|...::..|   |.|.|.:...::..:...:.:
Worm   484 SKNRAHNKSDSLVKNFGWPEAMFGDFNDFTTVDAYNQDYAS---IIDLYTKDKNDIYGIFAVLKK 545

  Fly   465 -FSSRHFQELTNDTKPQKILTGLQ----VGAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTL 524
             ...|.|..:..:  |......||    |.|.|....|||........||.|..:.|.:..|...
Worm   546 GMEVREFFRIMGE--PADRTNFLQSPAMVNAWYQPERNSITFPYAAWNPPYYNLNYPQAYNFAGQ 608

  Fly   525 GFIVGHELIHGFDTTSSYFDGNGHMESL-------LSEISQQALEDRAECYMDYYGKYQVPEISR 582
            |...||||.||:|.....|..||.:...       :...|.....|.|:|.:..:.....||.:.
Worm   609 GGTGGHELTHGYDDEGVQFGFNGELTDCSWNKCGWMDTNSSSGFIDMAQCVVTQFSTQCCPEKTG 673

  Fly   583 RV---NGKTTLDENIADNSGLRQALTAYRSHRQQL-LEHPGQERISDAMPGLD-LTPEQLFFLGF 642
            .:   ||.||..|||||..| :||  ||||:||.: ....|.|  .|.:|||: .||.|:|::.:
Worm   674 NIHCANGATTQGENIADLGG-QQA--AYRSYRQYVATTRKGVE--EDRLPGLENYTPNQIFWITY 733

  Fly   643 AQLFCSHYEEEH-YWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRP-GAKTCRLW 702
            ...:|....:.: ..:.|::.|:..|.|...|:.:..:|...:.|..||.|.| .:..|::|
Worm   734 GYSWCMKQSDANLVHQLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPMYPEPSGRCKVW 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	160/743 (22%)
nep-22	NP_509528.1	PepO	76..795	CDD:226118	161/752 (21%)
nep-22	NP_509528.1	M13	83..793	CDD:189000	160/743 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920