Protein Alignment Nepl12 and nep-21

DIOPT Version :9

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001360525.1
• Gene: nep-21 / 179925
• WormBaseID: WBGene00011794
• Length: 864
• Species: Caenorhabditis elegans
• Alignment Length: 806
• Identity: 204/806 - (25%)
• Similarity: 348/806 - (43%)
• Gaps: 178/806 - (22%)

  Fly     8 LISLMLLWV-IVAAVLTDCEARSL-----------VDRSENSDSNGSSTNRSAAEYQLQEYAEFM 60
            |:|::.||: ::....|..:.|.:           ||||..:.::...|:|...     ..|.|:
 Worm   126 LLSVLFLWLWVLDGYKTFTDGRPIYPLPFENSSVAVDRSAKNHNDVVCTSRECV-----RLAGFL 185

  Fly    61 KSYMNQSVEPCENFYEYACGNY---RNV---KPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLA 119
            ...:|..:.|||:|||:|||||   :|:   ||.|::      :.||...|   .:|:...:...
 Worm   186 AENLNSKINPCEDFYEFACGNYGLNKNLPANKPLRHT------ISDVQSRL---NKQVKSMLQSP 241

  Fly   120 EALNVSSELAVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAH 184
            .:.|......||:.:|..||..........: |...:.:.|||:|.::||.|:..:.:|....|.
 Worm   242 ISANEKPWDKVAKGYYQKCLDEEELESTGVE-AMRDIAKRIGGWPTLEGDKWQEWSHSWEEQIAL 305

  Fly   185 LANY-GANGLI-------------RETLQL---------RYPF-----EP----YTKLPE----- 212
            :.|. |.|.:|             |..::|         |||:     :|    ||.|.:
 Worm   306 VLNLTGVNAVILEMAVTHDPSNSSRSVIELDQPKWGAGSRYPYLSGANDPMLRNYTTLMKMTAVA 370

  Fly   213 LGFDHIIVHEENISRNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQ--C 275
            ||.|..|..:|   .|....|.|.       |..|. .:|.:|          ||     |:  .
 Worm   371 LGADPAIAEKE---MNEAMEFELK-------LVNFS-ADDMVR----------RD-----PERGN 409

  Fly   276 EVFDPYRIKRVFP--QSEYYYN------ISWSGLHSTNKLFCDFYYVELDKVC-ARHRKAVANYL 331
            ..|:.:::|.|||  ..|.|..      ::.|..|:......| |:|.:..|. :..::.:|||:
 Worm   410 NRFELWQLKSVFPFINFEKYLKTVFKELVALSPNHTVIVREID-YFVGIQHVLQSTPKRVLANYI 473

  Fly   332 AMKLL--------YRFDPKL----KAPRYQRNYCSVTLYQS----------------MRFLFNKL 368
            :.:|:        :.|.|.|    :.|.||.......::.|                |.....:|
 Worm   474 SWRLVQGGPTGDYFSFSPFLPPSAREPFYQFKANQTGMFNSPPPDRWEDCVTLSVIMMDMPVGRL 538

  Fly   369 YMANNFSEAKRL-EMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIG----SFQDD 428
            ::.|.|.:.:.: :|:|:...|:....|.|...||:|..:|.||:.|.:.|:.:.|    .|.|.
 Worm   539 FVENFFEKERAMKKMTELTSYLKNEFIKQLHVLDWMDEITRRRAISKANMIEYKSGFPMVLFNDT 603

  Fly   429 ALSDRIIREINSLKVIEDR-YAETNINLQHLVVQIN--RFSSRHFQELTNDTKP----QKILTGL 486
            .:      |.|...:|:.| |      |.||.:::.  ||:    :||....:|    ....:..
 Worm   604 WM------EKNWGMIIKPREY------LLHLTIRVKLVRFT----EELLRLDQPLDRSMWFQSPA 652

  Fly   487 QVGAGYYTPDNSINVM-AGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHME 550
            ||.| ||.|:|:..:. ||:::.|.....:|..:.:|.:|.::|||:.|.||.....:|..|::.
 Worm   653 QVDA-YYAPNNNEMIFPAGIMQFPFLTLGVPNYITYGMVGAVIGHEVSHAFDDQGGQYDEMGNLN 716

  Fly   551 SLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQL- 614
            ......:::...::..|::..|....|.|....:||:.:|.||||||.|::.|..||::.:...
 Worm   717 DWWDAETEEKFIEKTRCFVRQYENVHVVEADIHLNGQLSLGENIADNGGVKTAFNAYKAWKSNTT 781

  Fly   615 -LEHPGQERISDAMPGL-DLTPEQLFFLGFAQLFCSHYEEEHYWK-GLSDVHTFDQFRVLGVLSN 676
             :..|       |:||. :.|.:|:|||.:|..:||....:||.: .|:|||...::|.:..|.|
 Worm   782 GISEP-------ALPGFQNFTSQQMFFLAYANNWCSLVRPKHYIQIILTDVHAPSKYRAMIPLQN 839

  Fly   677 SEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ..:|..|:.|.:||.|.|..| |::|
 Worm   840 RPEFAKAFQCPIGSPMNPERK-CQVW 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	187/730 (26%)
nep-21	NP_001360525.1	M13	193..862	CDD:341056	187/730 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920