Protein Alignment Nepl12 and nep-23

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_503004.2
• Gene: nep-23 / 178472
• WormBaseID: WBGene00013785
• Length: 714
• Species: Caenorhabditis elegans
• Alignment Length: 783
• Identity: 170/783 - (21%)
• Similarity: 303/783 - (38%)
• Gaps: 160/783 - (20%)

  Fly     4 ESLKLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRS------AAEYQLQEY------ 56
            |.|..:|..:|.:||...:........:|:.|..::...|:..|      .|...|:::
 Worm     8 EKLSCLSTNILLLIVVIAIFGTVVIWKIDKLELWEAEALSSQESMLGELKVAVTSLEQHRPGHLK 72

  Fly    57 ------------AEFMKSYMNQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDIT 109
                        |..:.:|.:.|.:||:|||:..||.       ::....:|.|......|.::.
 Worm    73 KNVCQTPECITLAHQLHNYHDPSADPCDNFYQSVCGK-------QHEHSLKSGLAKKHLILRNLI 130

  Fly   110 EQLLGRMDLAEALNVSSELAVAQRFYNAC---LGANLHPFNAADPAYLSL------IRSIGGFPA 165
            .:.:....:.......:|:   ::|:..|   ..||    :::|.|..:|      ::|||.:||
 Worm   131 RETITNRKVTPTSKSENEM---RKFHGICSKYQRAN----SSSDIAQQALRDIFRDVQSIGSWPA 188

  Fly   166 VDGDAWKASNFNWINMSAHLANYGAN--GLIRETLQLRYPFEPYTKLPELGFDHIIVHEENISRN 228
            ...: |..|:||...|..:|...|..  ||.:.:.:.|              |.:::..|...||
 Worm   189 GSRN-WNESDFNLNEMLNNLVKLGQRNFGLFQISFKYR--------------DQLLISAEEHRRN 238

  Fly   229 TTRAFRLNEERMHGYLRAFGLPEDRIR-----EAIAGVFA-----FWRDAL---------EIPPQ 274
            .::.    |..:.......||..|||:     |..|.:.|     ::.|.:         ::.|.
 Worm   239 YSKL----EPTILNIFETNGLVPDRIQLLKDLEGFASLEALLKNHYYLDNMDKMKPAVLDDLVPS 299

  Fly   275 CE-------VFDPYRIKRVFPQSEYYYNISWSGLHSTNKLFCDFYYVELDKVCA-RHRKAVANYL 331
            .:       :..|.: :.:.|:.|    :..|.|:.|  ||.| ..:.|:.:.. ..::.:||||
 Worm   300 VDFMGLVKAMISPGK-EHLMPKIE----LKTSVLNQT--LFND-ENMNLEAIILDTPKRTLANYL 356

  Fly   332 AMKLLYRFDPKL-----KAPRYQRNYC--SVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVREL 389
            ....:   |..|     :....:.|.|  .|..|.....|  ::::.|...:..|..::::..:.
 Worm   357 IFNFI---DSSLDHLVFETTSQKGNTCEDKVITYLPRASL--RVFIRNYVDKENRDLITQLAEKT 416

  Fly   390 RKSLRKALEDADWLDAESRARALLKESRIQPRIG---SFQDDALSDRIIREINSLKVIEDRYAET 451
            |.:|...::::.||.|||:..||.|.:.:...||   .|:.....|.:.:.:| |...:..|...
 Worm   417 RIALHTLVQNSTWLKAESKQLALDKINAMGKMIGYPDFFEPPGTLDGMFKNLN-LDSSDTYYTAL 480

  Fly   452 NINLQHLVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLP 516
            |...::.|.|    ...:|.|   :|.....|...::.|.||.|.|.:|.:|...:.|::....|
 Worm   481 NKLERYFVEQ----KMDYFAE---ETPLDPDLRVFEMNAYYYIPGNQLNFLAPFFDDPMFDSTYP 538

  Fly   517 ISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEIS 581
            ..:.....|.|:|||:.|.|...:......|. |..:........|.||:|..:.|.:|..|:..
 Worm   539 DYVNIAMSGNIIGHEMGHAFGPHAILRTVRGR-EVWMKPEELAEYESRAQCLANQYSEYDDPDFG 602

  Fly   582 RRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTP------------ 634
            |..:|...:||.:|||.|...:...::|                    ||||.
 Worm   603 RVFDGGKVIDELVADNIGREVSWKMFKS--------------------LDLTNATRIIGFEDYDI 647

  Fly   635 EQLFFLGFAQLFCSHYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTC 699
            :||:|...|...|:.:........:...|....|||.||.:|..:|..|:||..||.|.| .|.|
 Worm   648 DQLYFRVGALTHCTPHAMRDLKGSIESSHPRKAFRVNGVYANLPEFARAFNCPTGSPMNP-RKKC 711

  Fly   700 RLW 702
            .::
 Worm   712 DMF 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	154/691 (22%)
nep-23	NP_503004.2	M13	96..711	CDD:341056	154/690 (22%)