DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl12 and nep-17

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001254395.1	Gene:	nep-17 / 174996	WormBaseID:	WBGene00010070	Length:	1589	Species:	Caenorhabditis elegans

Alignment Length:	791	Identity:	179/791 - (22%)
Similarity:	307/791 - (38%)	Gaps:	196/791 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SSTN---RSAAEYQLQEYAEFMKSYMNQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTY 103
            :|||   .:|.:..:..||   || :|.:::||::||.|||||: |.....|:..:: ||..:..
Worm   859 TSTNVDKMNAYQMAVDYYA---KS-VNTAIDPCDDFYSYACGNF-NQSVSFYTARAQ-NLVYMAQ 917

  Fly   104 TLIDITEQLLGRMDLAEALNVSSELAVAQRFYNACL----------------------------- 139
            .|.|.|.|        ..:|.|..|...::.|||||
Worm   918 KLEDPTYQ--------TTINSSPALKKEKQLYNACLTATASSQSEDQILISKNYIQTKVDDLKTL 974

  Fly   140 -GANLHPFNAADP------------AYLSLIRSIGGF--PAVD---------------------- 167
             |.:....|...|            .|||..:.|...  |.||
Worm   975 IGQDFTLVNGGAPKLPSAKQIGDALGYLSFEQGIDTLISPLVDTYWIDNSKGYQMFIDQNTAYLS 1039

  Fly   168 -----GDAWKASNFNWINMSAHLANYGANGLIRETLQLRYPFEPYTKLPELGFD---HIIVHEEN 224
                 ..|||.....::.|:..:..             ||..|....||....|   :::.:|:|
Worm  1040 KTYYQPAAWKIEKPKYLKMALDVVT-------------RYAREQNITLPAGASDLLSNVLDYEQN 1091

  Fly   225 IS------RNTTRAFRLNEERMHGYLRAFGLPE--DRIREAIAGVFAFWRDALEIPPQCEVFDPY 281
            |:      .||.|.|:          |::.|.:  |.:.:.   .|..|...|...|..
Worm  1092 IAVKYSTDDNTRRQFQ----------RSWNLTKTSDLVTKY---NFMDWMTYLSHAPNA------ 1137

  Fly   282 RIKRVFPQSEYYYNI---------SWSGLHSTNKLFCDFYYVELDKVCARH-------------- 323
             :|.....:.|..::         |...|..:.:|..:..:|.|....|::
Worm  1138 -VKAKITDANYQVSVMEVDRLTHFSADYLQQSPELLVNLLFVRLLLGNAQYIPSYASAFRGMTDE 1201

  Fly   324 --------RKAVANYLAMKLLYRFDPKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAK-- 378
                    ||.:.|::...   .||.:...|.     |:......|:|...::::...:..|:
Worm  1202 SIFLGLSRRKTIPNHIPPP---NFDLEANGPA-----CASVANNLMQFANGRVFVDYMYPTAQDV 1258

  Fly   379 ---RLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREINS 440
               |.....:::.:..|.:..::..||:..:::.:|..|..:||..| :|.|...:|.::....|
Worm  1259 TNIRKSAGGIIKNVISSFQGMIDQLDWMAPDTKQKAYAKTVQIQQNI-AFPDWIKNDTLLGNYYS 1322

  Fly   441 LKVIEDRYAETNINLQHLVVQINRFSSRHFQELTNDTKPQKILTGLQVGA--GYYTPD-NSINVM 502
            ..||.|  ::...::...:::.|.|.  .:.:|......:....| |.|.  .:|.|: |||...
Worm  1323 TLVIAD--SDNFYDIYDKLIKFNIFV--QYNQLNAAQTDRTDFLG-QPGTVNAWYQPELNSITFP 1382

  Fly   503 AGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAEC 567
            ||::.||.:..:.|.|:.:|.:|.:.||||.||||.....:...|::...:.:.|....::.::|
Worm  1383 AGILVPPYFNPNWPPSINYGGMGLVAGHELTHGFDDQGVQWGPTGNLARWMDDNSMAGFKNMSQC 1447

  Fly   568 YMDYYGKY---QVPEISRR-VNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMP 628
            .::.|..:   .....|.. |.|..|..||||||.|:..|..||::|  |.|:.| ..|:.|.:.
Worm  1448 VINEYSGFCPLNATNYSPNCVKGPQTQGENIADNGGVHAAFNAYKTH--QSLDGP-DPRLPDRLF 1509

  Fly   629 GLDLTPEQLFFLGFAQLFCS--HYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSG 691
            | ..|.:||||:.|||::|.  ..::..|.:.:.|.|:...:||.|.:.|...|..|:||.:||.
Worm  1510 G-QFTHDQLFFMSFAQVWCEVRRTDDALYTQIMVDPHSPSMYRVYGTIQNFPAFQTAFNCPLGSK 1573

  Fly   692 MRPGAKTCRLW 702
            ..| .:.|.:|
Worm  1574 SAP-EQHCEVW 1583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	168/758 (22%)
nep-17	NP_001254395.1	PepO	108..833	CDD:226118
		M13	112..830	CDD:189000
		PepO	880..1583	CDD:226118	170/764 (22%)
		M13	884..1581	CDD:189000	168/758 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020