Protein Alignment Nepl12 and nep-1

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_496490.2
• Gene: nep-1 / 174787
• WormBaseID: WBGene00013926
• Length: 754
• Species: Caenorhabditis elegans
• Alignment Length: 743
• Identity: 181/743 - (24%)
• Similarity: 316/743 - (42%)
• Gaps: 152/743 - (20%)

  Fly    54 QEYAEFMKSYMNQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRM-D 117
            ||.:..::..:|.|::||::|:||||..:.:..|   .|...::....|.|    .|::|..| .
 Worm    70 QEASRLLQKSLNLSLDPCDDFFEYACRAWVDSHP---IPDDLTSYSQFTAT----REKVLAEMRK 127

  Fly   118 LAE---ALNVSSELAVAQRFYNACLGANLHPFNAADPA-YLSLIRSIGGFPAVDGDAWKASNFNW 178
            |.|   ::..|..:|:.::.||.|:....|  ||.... .|..|::.|.:|.|..:.|:.|.|:
 Worm   128 LYEDNTSIPTSKSIALIKQIYNTCMDTEKH--NAVGARDLLEKIKTYGYWPMVHNEKWRESTFD- 189

  Fly   179 INMSAHLANYGANGLIRETLQLR-----YPFEPYTKLPELGFDHIIVHEENISRN---------- 228
                       ...|:..|:|.|     :.|.|            .....|:||.
 Worm   190 -----------LTKLLSNTIQSRDVSVFFDFGP------------AEDSRNVSRRLLSFDQGSLG 231

  Fly   229 ---TTRAFRLNEERMHGYLRAF-----------------GLPEDRIREAIAGVFAF---WRDALE 270
               :||.:.|:|::....::|:                 .:.|.:|...:..:.||   |...|.
 Worm   232 LGYSTRDYYLDEKKYEKQMKAYRKYTIGKVRYYTEDAGMAVNESKIESDVDEIIAFEKEWAQILV 296

  Fly   271 IPPQCEVFDP-YRIKRVFPQSEYYYNISWSGL---------HS---TNK--LFCDFYYVELDKVC 320
            .......:.. |.::|.....||...|.|..|         ||   ||.  :..|..|::.....
 Worm   297 AEEDRRNYTKLYNVRRFDDLKEYMSIIDWKKLTLSTTPFLVHSYLKTNPSIIISDVEYLQKMNTL 361

  Fly   321 ARHR--KAVANYLAMK--------------------LLYRFDPKLKAPRYQRNYCSVTLYQSMRF 363
            .::.  :.|.||:.::                    ....:..|.:.||::.  |..:....:.:
 Worm   362 LQNTDPRIVTNYILLRWAGSWSQEIGKKYEDLQQEFAFQMYGRKQRQPRWKD--CVSSAGGKLSY 424

  Fly   364 LFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDD 428
            ....:|:...|....:....:|:.:|:::.|..:...||:|||::..||.|..::..:|| :.|.
 Worm   425 ASGSMYVRKYFDANAKNTTLDMITDLQEAFRNMMHANDWMDAETKKYALEKADQMLKQIG-YPDF 488

  Fly   429 ALSDRIIRE-INSLK-VIEDRYAE---------TNINLQHLVVQINRFSSRHFQELTNDTKPQKI 482
            .|:|..:.: ...|: ..||.:::         .|...:.|:..:|||               :.
 Worm   489 ILNDEKLDDWYKGLEGAPEDSFSQLVEKSIQWRNNFYYRRLLEPVNRF---------------EF 538

  Fly   483 LTGLQVGAGYYTPD-NSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGN 546
            ::...|...:|:|. |:|...||:::.|.:....|.:|.:|.:|.::|||:.||||.|...||..
 Worm   539 ISSAAVVNAFYSPTRNAIAFPAGILQQPFFDARFPKALNYGGIGAVIGHEITHGFDDTGRQFDNV 603

  Fly   547 GHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHR 611
            |::.......:.....:|.:|.::.|...::.....|:|||.|..||||||.|::||..||:|:
 Worm   604 GNLRDWWDNTTSSKFNERTQCIIEQYADVKLRGTDLRINGKLTQGENIADNGGIKQAFKAYKSY- 667

  Fly   612 QQLLEHPGQERISDAMPGLD-LTPEQLFFLGFAQLFC-SHYEEEHYWKGLSDVHTFDQFRVLGVL 674
              |.:|.|||.   .:|..: ||.|||||:|:||::| :...|......|:|.|:.:..||..||
 Worm   668 --LEKHGGQEA---RLPQFESLTNEQLFFVGYAQVWCGAKTPETKTLLLLTDPHSPETARVNTVL 727

  Fly   675 SNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            :|..:|..|:.|..||.|.| .|.|.:|
 Worm   728 TNQPEFAEAFKCPAGSPMNP-TKRCVVW 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	175/725 (24%)
nep-1	NP_496490.2	M13	85..751	CDD:341056	175/723 (24%)