DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl12 and nep-26

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001022540.1	Gene:	nep-26 / 174593	WormBaseID:	WBGene00014171	Length:	807	Species:	Caenorhabditis elegans

Alignment Length:	757	Identity:	168/757 - (22%)
Similarity:	288/757 - (38%)	Gaps:	187/757 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 MNQSVEPCENFYEYACGNYRNVKPD-RYSPGSRSNLGDVTYTLIDITEQLLGRM-DLAEALNVSS 126
            ::||||||:|||::|||.:.|...: :|.  |.:.|.:...|..|...|.:.:: |.:..|..::
Worm   120 VDQSVEPCDNFYQFACGGWINQSVNLKYD--SWNTLYETQRTAHDQIVQAMHKINDGSYPLPTNA 182

  Fly   127 ELAVAQRFYNACLGAN------LHPFNAADPAYLSLIRSIGGF-PAVDGDA-------------- 170
            ....|.:.|..|:..:      ||       .:...:..:||: |.:...|
Worm   183 GERAAAKMYEQCMDTDTLEQTGLH-------LWERFVDELGGWMPELKNGALEQEESFEIELDED 240

  Fly   171 -------------------------WKASNFNWINMSAHLANYGANGLIRETLQLRYPFEPYTKL 210
                                     |.....|::|...||..      |.|.|.:....|.|...
Worm   241 EKKRRRFEIEDIILSAFNYSVFPLFWAGVEVNYLNSKEHLIT------IYEQLPILLAPEKYHYN 299

  Fly   211 PELGFDHIIVHEENISRNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVF-----------AF 264
            .||..:  :::.:......|||.:...|.:...| .|...::::|..||.:.           .|
Worm   300 KELTPE--MIYGKMEGPPVTRALQQVGEELSAVL-GFDSTDEKVRMMIANMIYLEYQITMAGSTF 361

  Fly   265 WRDALEIPPQCEVFDPYRIKRVFPQSEYYY--------NISWSGLHS------TNKLFCDFYYVE 315
            :::..|   :..|.....::.:.|...::|        |:|    ||      |...:.......
Worm   362 YKEKKE---RYTVVMLRELQEIAPAINWHYFLSRLVGENLS----HSEPIALKTGTQWIPILSAI 419

  Fly   316 LDKVCARHRKAVA---NYLAMKLLYRFDPKLKAPRYQRN--YCSVTLYQ---SMRFLFNKLYMAN 372
            ::|: .:.|..||   ||:..|.: .|.....:|:.:..  :.:|:||.   |.|..|..|.::.
Worm   420 VEKL-KQSRSGVAVLKNYVKWKTI-MFHLAYASPKCRDGLLWMAVSLYSGAASQRKEFCVLRLSG 482

  Fly   373 NFSEAKRLEMSEMVREL------RKSLRKALEDAD---------------WLDAESRARALLKES 416
            .|.    |.:..::|::      .|:::.....||               :.|.|:|...:.|.:
Worm   483 IFP----LSLPSILRKIDGIDHTEKNVKAVQNIADRIQEKYEEMVRSSNLFSDRETRENVIDKVN 543

  Fly   417 RIQPRIGSFQDDALSDRIIRE--------------INSLKVIEDRYAETNINLQHLVVQINRFSS 467
            .:...|| |.|...||..:.:              :.|..|.::|       ||.|.:.::..|
Worm   544 NMTKFIG-FPDAMRSDYEMEKEAVRLHDTLFWSMVLGSSSVYKER-------LQRLRLPVDPRS- 599

  Fly   468 RHFQELTNDTKPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHEL 532
                  ..||:|     .:.|.|..| ..|.:.:....:..|....|......:..:|.|:||||
Worm   600 ------WVDTRP-----AISVPAHNY-ERNLVQIPFDSLRLPYADEHQLDFANYAGIGTIIGHEL 652

  Fly   533 IHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVN-GKTTLDENIAD 596
            .|.||.........|::....|..|.:..:.|.:|::..|....   .|..:| .|..|.|||||
Worm   653 THAFDGQGKLHGPTGNLGVWWSTDSIREFKAREQCFVKQYAGLM---DSHDMNAAKEGLYENIAD 714

  Fly   597 NSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLD-LTPEQLFFLGFAQLFCSHYEEEHYWKGLS 660
            ..||:.|..|::|:..|         .|..||||: .:.:|||||.:.|.:|:...:.:..:
Worm   715 QVGLKVAYEAWKSNGNQ---------NSGRMPGLEKYSQDQLFFLAYTQGWCALRSKSYKLQ--- 767

  Fly   661 DVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
             .|..::.|:||.|.||.:|..|:.||..|.|.|..| |.:|
Worm   768 -PHMEERIRMLGSLQNSPEFASAWKCSSESFMNPPDK-CSIW 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	164/749 (22%)
nep-26	NP_001022540.1	PepO	111..807	CDD:226118	167/755 (22%)
nep-26	NP_001022540.1	M13	124..805	CDD:189000	164/749 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020