Protein Alignment Nepl12 and nep-5

DIOPT Version :9

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001364754.1
• Gene: nep-5 / 173933
• WormBaseID: WBGene00017393
• Length: 694
• Species: Caenorhabditis elegans
• Alignment Length: 696
• Identity: 129/696 - (18%)
• Similarity: 244/696 - (35%)
• Gaps: 167/696 - (23%)

  Fly    55 EYAEFMKSYMNQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLA 119
            :|:..:...|:.||.|||||:.:.|..:...|.|                    .|:|:..:::.
 Worm   115 KYSAELLELMDSSVNPCENFHHHVCNGFNPRKKD--------------------FERLMKLINIQ 159

  Fly   120 EALNVSSELAVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAV--DGDAWKASNFNWINMS 182
            |..:....:.|.:|..:.|.......           |..:|...::  .|..:...|.:|...|
 Worm   160 EKPDHRKAVNVVRRMLSKCAMGKTEE-----------IHQVGRLSSIILPGLPFPLLNNSWTKPS 213

  Fly   183 AHLANYGANGLIRETLQLRYPFEPYTKLPELGFDHIIVHEEN------ISRNTTRAFRL------ 235
            ..::...:      :....|||  .||:    ..|||:|..:      |..::...|.|
 Worm   214 DPISTSNS------STTYSYPF--LTKI----LAHIILHNPDDAGFVGIKPSSDSEFSLFVVKPF 266

  Fly   236 -------NEERMHGYLRAFGLPEDRIREAIAGVFAFWR------------DALEIPPQCEVFDPY 281
                   ....|:..|:. ..||......|...|...|            :.:|.....||.:..
 Worm   267 SPVLTNFKFRNMYDILKR-NAPESSTNGMIDLEFDRQRQLNDVIKLQTKLEKIEFKADPEVVNLT 330

  Fly   282 RIKRVFPQSEYYYNISWSGL----------HSTNKL--FCDFYYVELDK-VCARHRKAVANYLAM 333
            .|:|..|      .|.|..|          |...|:  |...||.|::. :.:...:.:.|:|.:
 Worm   331 EIQRQMP------IIDWKRLIDSWIPNGYAHLKEKVYGFNTSYYEEINAIISSTPSETIYNFLFL 389

  Fly   334 KLLYRFDPKLKAPRYQRNYCSVTLYQSMRFLFNKLYM-ANNFSEAKRLEMSEMVRELRKSLRKAL 397
            :..::| .:.:......:.|   |:|....:..|:.: .:...||..| ::.|:..::..|:::|
 Worm   390 RFSFKF-LRTEVASDLEDTC---LHQLSTTIPGKIVLYGSEEPEALNL-LNGMLHTIKDQLKRSL 449

  Fly   398 EDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREINSLKVIEDRYAETNINLQHLVVQI 462
            ....|:|:.....|..|.::.:...| |..:.|.|.::.:|..    |..|..|   ||::::..
 Worm   450 ATLKWMDSRGIEEAQKKFNKTKTVFG-FTGEDLIDELVGKITP----ESNYIST---LQNVLLWQ 506

  Fly   463 NRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTLGFI 527
            .|       .:........:...|.....|....|.|.:...::..|....:||....|.|:...
 Worm   507 TR-------NMFKSVAENNVTVFLNSEVFYSVEKNEITISRALLHYPFMSANLPNYTNFATIASK 564

  Fly   528 VGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDE 592
            :..::||.||....::|.:|:..:..:..:::..:...:|:                      |.
 Worm   565 ILPQMIHIFDERGRFYDSDGNHRNWWNTETERYFQIIVQCF----------------------DG 607

  Fly   593 NIADNSGLRQAL--TAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHY 655
            .:.:..|:..::  .||.|.::.....||.::.||         |.|||....:..|
 Worm   608 MMQNVFGVSVSIGWNAYDSTKEPYATLPGIQQSSD---------EALFFYSMVKTMC-------- 655

  Fly   656 WKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRL 701
                    |.|...|...|::...|..|:.|:.|:.|.|..| |:|
 Worm   656 --------TSDPDNVNEALASVPQFNSAFKCNNGTKMNPPTK-CKL 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	124/680 (18%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:417498	124/680 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920