DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl12 and nep-12

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001364537.1	Gene:	nep-12 / 173824	WormBaseID:	WBGene00017842	Length:	832	Species:	Caenorhabditis elegans

Alignment Length:	815	Identity:	194/815 - (23%)
Similarity:	339/815 - (41%)	Gaps:	192/815 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SLKLISLM--LLWVIVAAVLTDCEARSLVDRSE-------------NSDS-NGSSTNRSAAEYQL 53
            :|.:::|:  :.::.:.|:|:| ...:|:..||             ||:. |..|.|.:....:.
Worm    93 ALFILTLLISISFITIVAILSD-GFSTLISGSELCSNTEGDAYEVKNSNHVNYGSDNSTCLTPEC 156

  Fly    54 QEYAEFMKSYMNQSVEPCENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRM 116
            ...|....:.||:...|||:|||:|||.|  |.|..:....             :.:..::...|
Worm   157 IRLAASYLNNMNRDANPCEDFYEFACGKYATRKVIAEHEKK-------------VTVLSEMKKEM 208

  Fly   117 D--LAEAL------NVSSELAVAQRFYNACLGANLHPFNAAD---PAYLSLIRSIGGFPAVDGDA 170
            |  |.:.|      |.:..:.:||.::::|    :..|:..|   ...:|:|.::||:|.:....
Worm   209 DRHLKDILEKTSRENTTRSMKLAQIYFDSC----MDEFSQDDLGVQPLMSMISNLGGWPLLTNAR 269

  Fly   171 WKASNFNWINMSAHLANYGANGLIRETLQLRYP--------FEP----------YTKLP------ 211
            :.:.:|.|..::.|||.||.:|:.|..:...:.        |.|          |.::|
Worm   270 FDSIDFQWEVLAGHLALYGVDGIFRVFVHSSFDDSDKNVLMFSPPKLFLEKKKFYREVPSSNVYL 334

  Fly   212 -------------------------ELGFDHIIVHEENISRNTTRAFRLNEERMHGYLR------ 245
                                     |...|.||..|..|:..|    |:...|.|..:.
Worm   335 QYYRQYILSLLSLLGVDMEDETGVIEYQVDDIIDFERRIANLT----RIELSRNHSSINNMITFG 395

  Fly   246 AFGLPEDRI------REAIAGVFAFWRDALEIPPQCEVFDPYRIKRVFPQSEYYYNISWSGLHST 304
            .|....|:|      .|.:.|......|:|.|    .|.|          ..|:.|     |:|.
Worm   396 EFKRKYDKINWDAFFNEEMRGNLGRMPDSLVI----NVVD----------VNYFDN-----LYSL 441

  Fly   305 NKLFCDFYYVELDKVCARHRKAVANYLAMKLLYRFDPKLKAPRY--------QRNY--------- 352
            .|              ::...::.|:|...|:..:|..|.| :|        |:.|
Worm   442 IK--------------SKPLSSINNFLMWCLVSNYDMYLPA-KYRKPMLDFRQKMYGVSSDDPLW 491

  Fly   353 --CSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKE 415
              |...:.:::....:..|....|::..:|...:|:|:|:|::.:.|.:|||:|..:|..||:|.
Worm   492 EVCVGEVRENLAMPLSTEYAQKFFTKKDKLVAEDMIRDLKKAMEQTLLNADWIDESTREAALMKL 556

  Fly   416 SRIQPRIGSFQDDALSD-RIIREINSLKVIEDRYAETNINLQHLVVQINRFSSRH-FQELTNDTK 478
            ..:..:|| |.|..|:: .::.....:::..::|.:..|:|:....: :..|..| ...|.:...
Worm   557 DAMGHKIG-FPDSLLNETAVLLPYAGVRLTANQYFDNAISLKKAAYR-DALSKLHRTPSLIDWAS 619

  Fly   479 PQKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYF 543
            |.     :.|.|.:|...|.|...||:::.|::....|....:|.:|..:|||:.||:|...:.:
Worm   620 PI-----IAVDAFHYFTGNEIIFPAGILQFPMFVPDAPAFSNYGAIGMGIGHEITHGYDDLGAQY 679

  Fly   544 DGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAY- 607
            |..|::.......:....:.:.:|::..||....|:..|:|:||.|:.||||||.|||.|..||
Worm   680 DDKGNLRGWWHTETMTTFQKKKQCFVAQYGSKIEPQTGRKVDGKMTIGENIADNGGLRVAFQAYQ 744

  Fly   608 -RSHRQQLLEHPGQERISDAMPGL-DLTPEQLFFLGFAQLFCSHYEE---EHYWKGLSDVHTFDQ 667
             ||.|         |:.:..:||| |.:|.|||||.:|..:|...:.   :|...  :|||:...
Worm   745 LRSDR---------EKETRRLPGLTDFSPNQLFFLAYANTWCEALKPSAIDHIMD--TDVHSLGM 798

  Fly   668 FRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            |||...|.|...|...::|.:||.|.|..| ||:|
Worm   799 FRVNVPLQNLPAFSKEFDCPIGSPMNPFEK-CRIW 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	175/732 (24%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	175/732 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920