DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl12 and Mme

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001276391.1	Gene:	Mme / 17380	MGIID:	97004	Length:	750	Species:	Mus musculus

Alignment Length:	800	Identity:	193/800 - (24%)
Similarity:	330/800 - (41%)	Gaps:	181/800 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEP 70
            :.|..|:||..|:|..:.     :|....::.....|...:|||.         :...|:.||||
Mouse    29 ISLSVLVLLLTIIAVTMI-----ALYATYDDGICKSSDCIKSAAR---------LIQNMDASVEP 79

  Fly    71 CENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAV--A 131
            |.:|::||||.:  |||.|:..|..|..::      |.|..|.:|  .|:.:.......:||  |
Mouse    80 CTDFFKYACGGWLKRNVIPETSSRYSNFDI------LRDELEVIL--KDVLQEPKTEDIVAVQKA 136

  Fly   132 QRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVD-------GDAWKASNFNWINMSAHLANYG 189
            :..|.:|:..:........| .|.|:..|.|:|...       |.:|.|..    :::...:.||
Mouse   137 KTLYRSCINESAIDSRGGQP-LLKLLPDIYGWPVASDNWDQTYGTSWTAEK----SIAQLNSKYG 196

  Fly   190 ANGLI---------RETLQLRYPFEPYTKLPELGF---------------DHII----------- 219
            ...||         ..|..:.:..:|...||...:               |.:|
Mouse   197 KKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQS 261

  Fly   220 --VHEENISRNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCEVFDPY- 281
              :.|..:|....:...|.:|    ...|...||||                        .||.
Mouse   262 LPIDENQLSLEMNKVMELEKE----IANATTKPEDR------------------------NDPML 298

  Fly   282 --------RIKRVFPQSEYYYNISWSGLHSTNKL----------------FCDFYYVELDKVCAR 322
                    :::..|.......:.|||..  ||::                :...|..:|..:..:
Mouse   299 LYNKMTLAKLQNNFSLEVNGKSFSWSNF--TNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTK 361

  Fly   323 HR-KAVANYLAMKLLYRFDPKLKAPRYQRNY-----------------------CSVTLYQSMRF 363
            :. :.:.|.::.:.:......|     .|||                       |:..:..:|..
Mouse   362 YSPRDLQNLMSWRFIMDLVSSL-----SRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMEN 421

  Fly   364 LFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDD 428
            ...:||:...|:...:..:.:::.::|:...:.|:|..|:|||::.:|..|...|:.||| :.||
Mouse   422 AVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIG-YPDD 485

  Fly   429 ALS--DRIIREINSLKVIEDRYAETNINLQHLVVQINRFS-SRHFQELTNDTKPQKILTGLQVGA 490
            .:|  :::..|...|...||.|.|.       ::|..:|| |:..::|.......:.::|..|..
Mouse   486 IISNENKLNNEYLELNYREDEYFEN-------IIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543

  Fly   491 GYYTPD-NSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLS 554
            .:|:.. |.|...||:::||.:......||.:|.:|.::|||:.||||.....|:.:|.:....:
Mouse   544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWT 608

  Fly   555 EISQQALEDRAECYMDYYGKYQVPEI-SRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHP 618
            :.|....:|:::|.:..||.:..... .:.:||..||.||||||.|:.||..||    |..::..
Mouse   609 QQSANNFKDQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYRAY----QNYVKKN 669

  Fly   619 GQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFH 682
            |:|::   :|||||..:|||||.|||::|..|..|:....: :|||:...||::|.|.||.:|..
Mouse   670 GEEKL---LPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFAD 731

  Fly   683 AYNCSVGSGMRPGAKTCRLW 702
            |::|...|.|.|..| ||:|
Mouse   732 AFHCRKNSYMNPERK-CRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	177/734 (24%)
Mme	NP_001276391.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_001276391.1	M13	77..748	CDD:341056	177/734 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841053
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850