Protein Alignment Nepl12 and nep-3

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_494679.2
• Gene: nep-3 / 173730
• WormBaseID: WBGene00016778
• Length: 634
• Species: Caenorhabditis elegans
• Alignment Length: 732
• Identity: 156/732 - (21%)
• Similarity: 272/732 - (37%)
• Gaps: 150/732 - (20%)

  Fly     8 LISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEF------MKSYMNQ 66
            :|.|.:..:::..::...||..:......:.||.|:::.|.....:....|.      :.::.:.
 Worm    16 IIILAVPIIVILPLVLLLEAGKIGGEVSENCSNHSTSSASPKPKPMCLTPECITLVHQLLNFQDP 80

  Fly    67 SVEPCENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELA 129
            ||:||||||:.|||.|  .||     ..|||      |.....|.::|:.........:.|....
 Worm    81 SVDPCENFYQAACGKYNEHNV-----IDGSR------TAQKQQIVKRLIRDFLHKNQSSTSKSEN 134

  Fly   130 VAQRFYNACLGAN----LHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANYGA 190
            ..:..|..|..|.    |...|.....::: |:.||.:|.:| :.|....||...|...|...|.
 Worm   135 SMKLLYEKCKEAKTIKVLGNQNLLQEIFMN-IQKIGSWPVLD-ENWDGKKFNLNEMLLSLIRLGV 197

  Fly   191 NGLIRETLQLRYPFEPYTKLPELGFDHIIVH---------------EENISRNTTRAFRLNEERM 240
            :                    ..||..||:.               .||:|...::.|..|
 Worm   198 S--------------------NFGFFEIIISSDAFVEIKPARNFPTRENLSDIISKVFLGN---- 238

  Fly   241 HGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCEVFDPYRIKRVFPQSEYYYNISWSGLHSTN 305
             |:.......|:.:||                                    |.|:. ..|.|..
 Worm   239 -GFQPNITAIENDLRE------------------------------------YENLQ-RELKSLE 265

  Fly   306 KLFCDFYYVELDKVCARHRKAVANYLAMKLLYRFDPKLKAPRYQRNYCSVTLYQSMRFLFNKLYM 370
            :|           :.....:::.|||...  |.....|:..|.....|...:...:.....::::
 Worm   266 RL-----------IQTTPNRSLVNYLIFN--YLKSVMLEYKRLPEEQCEGVVIDFLPRASTRVFV 317

  Fly   371 ANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIG---SFQDDALSD 432
            .|...:..|..::.|:.:::......::::.||:.||:..|:.|...|:..||   .|:.....|
 Worm   318 QNFLDKENRKYVAGMIEDVKMGFIDMIQESTWLNEESKKVAVQKVKNIKSMIGYPDFFEPPGTLD 382

  Fly   433 RIIREINSLKVIE--DRYAETNINLQHLVV-QINRFSSRHFQELTNDTKP----QKILTGLQVGA 490
            |..:::|    ||  |.|        |.:| :|.:|::....|......|    |.||.    ..
 Worm   383 RSFKDLN----IEQTDSY--------HTIVRKIQKFTNEQCMEFVASEIPLDPRQPILH----AN 431

  Fly   491 GYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSE 555
            .:|...|.:.::|.|::.||:....|..:....:|.::.||:.|.||.|...:|..|.....|:.
 Worm   432 AFYQNTNFLAILAPVLDDPIFDTTFPRYVNLAVIGNVLAHEIGHAFDHTGINYDDAGQQRIWLTP 496

  Fly   556 ISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQ 620
            ...:....|..|.:..:.:|..|:..|.:||..||.|..||..|:.   .|:|:.::..|.:.
 Worm   497 EDSEEYGKRLRCLLRQHDEYDDPDFGRNLNGSKTLHEISADRFGVE---AAWRTFKKLDLSNE-- 556

  Fly   621 ERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYN 685
               |:.:...:...:||:|...|.::|...:.......|...|..:.|||.|:.:|...|...:|
 Worm   557 ---SEIVGFQNFNIDQLYFRTAALIWCRQRDTTDLQYALQREHPTNNFRVNGIYANMPQFAETFN 618

  Fly   686 CSVGSGMRPGAKTCRLW 702
            |.:||.|.| .|.|.|:
 Worm   619 CPLGSPMNP-KKKCDLF 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	144/662 (22%)
nep-3	NP_494679.2	M13	82..631	CDD:341056	144/661 (22%)