DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl12 and nep-10

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_494532.2	Gene:	nep-10 / 173684	WormBaseID:	WBGene00017555	Length:	711	Species:	Caenorhabditis elegans

Alignment Length:	774	Identity:	173/774 - (22%)
Similarity:	294/774 - (37%)	Gaps:	161/774 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SLMLLWVIVAAVLTDCEARSLVD-----RSENSDSNGSSTNRSA---AEYQLQE----------- 55
            :|.||.:||...|.....:..:|     :|::....|....:.|   :|.|..:
Worm    18 ALNLLLLIVFLALVTVHIKMTIDVAPVFKSDDPLPRGDPDQKPATIDSETQTVDEPRNVCESPEC 82

  Fly    56 --YAEFMKSYMNQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDL 118
              .|..:.:|.:.||:||::||::.||.:.     .:|...:..:.....||..:..:.|    |
Worm    83 ITLAHELHNYKDPSVDPCQDFYQHFCGKFY-----EHSAIGQGRMATKRSTLSKLIREFL----L 138

  Fly   119 AEALNVSSELAVAQRFYNACLG-ANLHPFNAADPAYL----SLIRSIGGFPAVDGDAWKASNFNW 178
            ....:.|......::.|..|.. ..:...|:..|..|    |.|:.||.:|.:|.| |..|.||.
Worm   139 KNKTSTSKSENTMKQVYAKCRELQKISDLNSIPPQALLDIFSDIKKIGAWPVLDKD-WDGSKFNL 202

  Fly   179 INMSAHLANYGANGLIRETLQLRYPFEPYTKLPELGFDHII----------------VHEENISR 227
            ..|...|.|.|      ||              .|||.|..                |.:..:.:
Worm   203 NEMLRQLVNLG------ET--------------HLGFFHFDFIARPYVLIKPPLKQGVQKSVLEK 247

  Fly   228 NTTRAFRLNEERMHGYLRAFGLPED-----------------RIREAIAGVFA------FWRDAL 269
            ........||.:|..     |..||                 |...:|.|:..      |....|
Worm   248 VVKMILEANEIKMDQ-----GFSEDLDEYFELSNRIKIDKLPRTSRSIVGLLPDVRRINFRGLIL 307

  Fly   270 EIPPQCEV--FDPYRIKRVFPQSEYYYNISWSGLHSTNKLFCDFYYVELDKVC-ARHRKAVANYL 331
            |:.|:.::  |    :..:|.:...|::..:...:.||         .||.:. :...:|:||||
Worm   308 EMMPRSKMNRF----LGTLFQKVVTYHHPLFVRDNETN---------HLDTIIRSTSNRALANYL 359

  Fly   332 AMKLLYRFDPKLK----APRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKS 392
            ....::   ..:|    ..:..|..|...:.|.:.....:::|.|...:..|.|::::...::::
Worm   360 IFNFIH---SSIKFLTFGLKSDRERCEKIVVQELPRPSLRVFMRNCVDKGNREEVAKLTETVKEN 421

  Fly   393 LRKALEDADWLDAESRARALLKESRIQPRIG---SFQDDALSDRIIREINSLKV-IEDRYAETNI 453
            :.:.:.::|......:.|.|.|...|...||   .|......|   :|..:|.: ..|.|.:.:.
Worm   422 VLEMIRESDSFTPSVKKRVLKKVEAIGAIIGYPDHFDPPGTLD---KEYENLTLDASDSYYKMSQ 483

  Fly   454 NLQHLVVQINRFSSRHFQE-LTNDTKPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLPI 517
            .|..|.:|       |..| |...|........|:|.|.|.:.||::.|:|..::.|.:....|.
Worm   484 KLHQLRLQ-------HQMEFLAGQTPLSPSDQVLEVNAHYDSKDNALTVLAPFLDDPFFDSTYPE 541

  Fly   518 SLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISR 582
            .:.....||::|||..|..|......||....|. ::|..:     ||:|.:|.|..|..|:..:
Worm   542 YVNLIFTGFLIGHEFGHSIDPKILRRDGWYKTED-MTEYGK-----RAQCLIDQYDNYDDPDHGK 600

  Fly   583 RVNGKTTLDENIADNSGLRQALTAYR----SHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFA 643
            ::||...:.|.:.|..|......|::    |..|:|:   |.|         |...:||:|...:
Worm   601 QMNGTYCIGEIVGDWVGRDVTWRAFKKMDLSKMQKLI---GFE---------DKNLDQLYFRIQS 653

  Fly   644 QLFCSHYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ..||.....:...:.|||.|..:.|||.|:.||...|..|:||.:||.|.| .|.|:::
Worm   654 LFFCGPRSMKSLEQLLSDPHPTEVFRVNGIYSNMPQFAKAFNCPIGSPMNP-EKKCKMF 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	157/691 (23%)
nep-10	NP_494532.2	M13	97..709	CDD:189000	157/691 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870