Protein Alignment Nepl12 and nep-9

DIOPT Version :9

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_494531.2
• Gene: nep-9 / 173683
• WormBaseID: WBGene00017554
• Length: 700
• Species: Caenorhabditis elegans
• Alignment Length: 703
• Identity: 146/703 - (20%)
• Similarity: 274/703 - (38%)
• Gaps: 132/703 - (18%)

  Fly    57 AEFMKSYMNQSVEPCENFYEYACGNYRNVKP-DRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAE 120
            |:.:|:|.:.:.:.||:||:..|.||::.:. ||:....:...         :.:.:.|.:...|
 Worm    73 AQELKAYSDTATKSCEDFYKATCENYKDHQALDRHRDCKKRKA---------VNKLVRGFLQRDE 128

  Fly   121 ALNVSSELAVAQRFYNAC--LGANLHPFNAADPAYLSL---IRSIGGFPAVDGDAWKASNFNWIN 180
            :...|...:..:..:..|  |..|        .:||.:   |:.||.:|.::.: ||.|.||..:
 Worm   129 STFTSESESAIKLIFGKCDELSRN--------TSYLDIFKDIKKIGSWPVLEHN-WKDSMFNLDD 184

  Fly   181 MSAHLANYGAN--GLIRETLQLRYPFEPYTKLPELGFDHIIV-----HEENISRNTTRAFRLNEE 238
            :.|.|...|:.  ||.:  |:||          :|.|.|..|     .|:||.:        .|:
 Worm   185 VIAKLVKLGSTDFGLFK--LELR----------KLAFGHFAVFVSSKQEQNIHQ--------LEK 229

  Fly   239 RMHGYLRAFGLPEDRIREAIAGV--FAFWRDALEIPPQCEVFDPYR-----------IKRVFPQS 290
            .:.|.|:|.|:.:|| :|....:  ::.:::.|:...|.|.:..||           |..:..|.
 Worm   230 TILGILKANGIQQDR-KELSDDLKDYSDFKNHLKEFYQEETYIEYRLYAGSIVENLGISSLTTQM 293

  Fly   291 -------EYYYNISWSGLHSTNKLFCDFYYVELDKVCARHRKAVANYLAMKLLYRF-DPKLKAPR 347
                   :.:.:::...|.:.:.||    :.|.:.:....:|.....||..|::.| |.......
 Worm   294 ALKSTGLDVFNHVNQRTLITNSSLF----FGEENNLGMIIQKTPKRTLANFLIFHFIDVMTTDLA 354

  Fly   348 YQRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADW-------LDA 405
            .....|..||...:.....::...|..:|..:.:|.:|.::|:..:.:.::::.:       .||
 Worm   355 NATKACKETLIDLLPRASIQVLSRNFVNEDAQDDMVKMAQDLKTKITEMIDNSPFFTKFHLVFDA 419

  Fly   406 ESRARALLKESRIQPRIGSFQDDAL-----------SDRIIREINSLKVIEDRYAETNINLQHLV 459
            |.:.:.:.|...| ..:..:..:.|           ||.|.|.|..|:.:.
 Worm   420 EEQKKLIQKVKAI-GIVTEYPQEVLDRDFERLNLTPSDSIYRTIQKLRRLR-------------- 469

  Fly   460 VQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTL 524
                  |.:..:.|..|..|..  |.:...|.|....|::.:.|.:::.|.:....|..:....:
 Worm   470 ------SEQLIEHLGGDLDPTD--TRVWGSAHYDQTTNNLTIFAPIIDGPYFDTSYPNYVNQFLM 526

  Fly   525 GFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEIS-----RRV 584
            |||:|.||....|:.....|..|..|:.|...|.:..::..:|:.:.|.|...|..|     |::
 Worm   527 GFILGRELGRSLDSVRIRKDEKGQTENWLKPESLKRFDEHLKCWAEKYDKSADPLKSESKGIRQI 591

  Fly   585 NGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSH 649
            .|:...:|..||..|...:..|:..     |:...:| :.:....:.|  .::||...|..||..
 Worm   592 EGRYIQNEMFADFIGHEASWRAFMK-----LDVKNEE-VLETFKVIKL--RRMFFNVQALYFCRP 648

  Fly   650 YEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ......|....:.|....|||.|...|...|..|:.|:....|.|..| |.::
 Worm   649 PSGSTDWLSYQEHHQHYSFRVNGAFKNMPQFALAFECASDDDMNPQNK-CSMF 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	142/688 (21%)
nep-9	NP_494531.2	M13	87..698	CDD:189000	142/685 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910