Protein Alignment Nepl12 and nep-13

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001342017.1
• Gene: nep-13 / 173672
• WormBaseID: WBGene00018196
• Length: 732
• Species: Caenorhabditis elegans
• Alignment Length: 738
• Identity: 167/738 - (22%)
• Similarity: 304/738 - (41%)
• Gaps: 105/738 - (14%)

  Fly     8 LISLMLLWVIVA----AVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSV 68
            |||:::..||:|    ||:......|.......:|.|.:......||  ....:..:.::.|.::
 Worm    42 LISIIICLVIIAICMGAVIVFWRMDSAPQAICKTDHNKTRDVCKTAE--CITLSSTLLNWQNTNI 104

  Fly    69 EPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAVAQR 133
            :|||:||||:||.|:.   ...:.|.|:|..|.      |..:|:.:..|......|:.......
 Worm   105 DPCEDFYEYSCGRYQE---HTLNDGIRANEKDT------IVMKLIRQFVLKNQSTTSNSENALML 160

  Fly   134 FYNAC----LGANLH-PFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINM-----SAHLANY 188
            .|..|    ...|.| ............||.||.:|..|.: |.:|:||..||     |.|:..:
 Worm   161 LYEKCSLRYRMENRHQETEVIQREVFENIRKIGSWPIADKN-WNSSHFNLNNMLSNMASIHMLPF 224

  Fly   189 GANGLIRETLQLR-YPFEPYTKLPELGFDHIIVHEENISRNTTRAFRLNEERM----HGYLRAFG 248
            |    :.||..:. ||.....|             :.:.|.|...|.:.:|.:    ...|...|
 Worm   225 G----LFETRVIELYPMNTTAK-------------QLVIRPTKLKFSIPQEELVRAIRDLLSVNG 272

  Fly   249 LPE--DRIREAIAGVFAFWRDA--LEIPPQCEVFDPYRIKRVFPQSEY------YYNI---SWSG 300
            :..  .:::|.:|..||..::.  :.|.||.:......:::..|..::      |.|.   :||.
 Worm   273 ITSIMKKVKEDVAESFALDKEIGNIHIDPQPKPATLSELQKAVPDIDFERIIKSYLNPKTGNWSS 337

  Fly   301 LHSTNKLFCDFYYV------ELDKVCARHR-KAVANYLAMKLL-----YRFD-PKLKAPRYQRNY 352
            |.:  |:|...:.:      .|..:.||.: :.:||||.:|.:     :.|| .|:.:   ..::
 Worm   338 LRT--KIFSARFELFFGKNNNLSSIIARTKPRILANYLFLKYIEYAYFFFFDNTKVFS---DDDF 397

  Fly   353 CSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESR 417
            |:..:..|:.....::::.|:|.:......||:|..::.:..:.:.::.||...:|..|:.|..:
 Worm   398 CTEVVTTSLPRASLRVFVRNHFKKENMAVASEIVEVVKTAYVEIINNSTWLHNSTRESAIEKVVK 462

  Fly   418 IQPRIGSFQDDALSDRIIREINSLKVIEDRYAETNINLQH----LVVQINRFSSRHFQE-LTNDT 477
            ::..||          ...|......:::.:....::...    |:.::|||......: :::|:
 Worm   463 MKKVIG----------YTEEYERTGALDEMFETLQLSRSDSFFVLMTKVNRFKIEQLMDFVSSDS 517

  Fly   478 KPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSY 542
            ....|...:...|.|:...|.:||:...::.|::....|..:....:|.::.||:.|.||.....
 Worm   518 LLNPIEPLVMANAFYFPTKNLLNVLVPFLDKPLFDFKYPRYVAMAGVGRVLAHEIGHAFDINGRQ 582

  Fly   543 FDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAY 607
            .|..|......:....:..:.|:||:.:.:..::.|....:.||...|.|.|||..|:..:..|:
 Worm   583 TDEIGRTRDWWTREDTEEYDRRSECFAEQFTNFKDPSFKGKQNGTEVLAEIIADALGMEASWIAF 647

  Fly   608 RSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYE-EEHYWKGLSDVHTFDQFRVL 671
            :  :..|.|..|..:..|...|      :|:|...|..||:... ||.|...||  |..::||:.
 Worm   648 K--KINLTEEQGLIQFEDHDFG------KLYFQVAALDFCAPSRIEERYSDQLS--HPTNKFRIN 702

  Fly   672 GVLSNSEDFFHAYNCSVGSGMRP 694
            |..|||..|...|.|.|||.|.|
 Worm   703 GAFSNSRAFADTYKCPVGSKMNP 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	153/674 (23%)
nep-13	NP_001342017.1	M13	104..729	CDD:341056	153/674 (23%)