Protein Alignment Nepl12 and Nep2

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_061497288.1
• Gene: Nep2 / 1281326
• VectorBaseID: AGAMI1_002834
• Length: 792
• Species: Anopheles gambiae
• Alignment Length: 806
• Identity: 210/806 - (26%)
• Similarity: 337/806 - (41%)
• Gaps: 167/806 - (20%)

  Fly     6 LKLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSS---------------------TNRSAA 49
            |.||| ::..|.|.|::.......|.||.::..|:.|:                     :.:||.
Mosquito    45 LTLIS-VVCGVAVVALIISLLTVVLTDRIQSESSSSSAQPLTAGRRGKALNKHPNTVVDSGKSAE 108

  Fly    50 EYQLQ----EYAEFMKSYMNQSVEPCENFYEYACGNY--RNVKPD-RYSPGSRSNLGDVTYTLID 107
            ...|.    ..|......|:|.||||::||.||||.:  ..|.|| :.|..:.|.:||      .
Mosquito   109 NICLTPGCIHSASKALEQMDQEVEPCDDFYNYACGKFVKETVIPDEKVSVNTFSVIGD------R 167

  Fly   108 ITEQLLGRMDLAEALNVS--SELAVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDA 170
            :.:||  |..::|.::.|  :...:|:..|..|:...........| .|.:...:||:|.:.||:
Mosquito   168 LQQQL--RSLVSEEISDSEATPFKLAKNLYKLCMNKTRIEEKGIKP-LLDIHEVLGGWPVLKGDS 229

  Fly   171 WKA-SNFNWINMSAHLANYGAN----------------------------GLIRETL--QLRYPF 204
            |.. |:::|:.......|.|.:                            |:.||.|  .:..|.
Mosquito   230 WDLDSSWSWVKSVKDFRNNGYSTDYFFDFSIGSDLKNSTRRIIDTDQASLGISREYLVKGMENPI 294

  Fly   205 EP--YTKLPE----LGFDHIIVHEENISRNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFA 263
            ..  |..:.:    ||.|     ||...|....:  ||.|..   |....||.::.|.|.|
Mosquito   295 VSAYYNYMVDMAVLLGAD-----EERAKRELLDS--LNFEMA---LANISLPNEKRRNATA---- 345

  Fly   264 FWRDALEIPPQCEVFDPYRIKRVFPQSEYYYNISWSGLHSTNKLFCD----------------FY 312
                         :::|..:|..  |..|.|. .|  |...|.:..|                .:
Mosquito   346 -------------LYNPMTVKEF--QQRYPYT-DW--LEYFNAILKDTGIVIGEEEVIIVSVPTF 392

  Fly   313 YVELDKVCARHRKAV-ANYLAMKL----LYRFDPKLK----------------APRYQRNYCSVT 356
            ..:|..:.....|.| |||:..::    .:....||:                .||::.  |...
Mosquito   393 MEQLGPLLQNTPKRVMANYVMWRISGFSSFFLTEKLRKRQLQYSTALSGKQEQEPRWKE--CVDI 455

  Fly   357 LYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPR 421
            ...|:......||:...|.|..:....:||.:::......|:..||:|..:|..||.|.|.:...
Mosquito   456 TSGSLPISVGALYIRKYFREDSKRAALDMVNDIKSVFVDILKKVDWMDEVTRVSALEKVSTMATH 520

  Fly   422 IGSFQDDALSDRIIREINSLKVIEDRYAETNINLQHLVVQINRF-SSRHFQELTNDTKPQKILTG 485
            || :.|:.:.|..|.|.  .|.:|.:...|.:|   .::.:|:| :::.|::|.........:|.
Mosquito   521 IG-YPDELMDDAKIAEY--YKDLEFQPDSTYLN---TILYMNKFGTTKAFKKLRIAVNKTDWITH 579

  Fly   486 LQ---VGAGYYTPDNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNG 547
            .:   |.|.|.:.:|||...||:::...:....|..:.:|.:||::|||:.||||.....||.||
Mosquito   580 SRPAIVNAFYSSIENSIQFPAGILQGQFFSYDRPKYMNYGAIGFVIGHEITHGFDDQGRQFDKNG 644

  Fly   548 HMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQ 612
            ::.......::.|..::|.|.::.||.|..|.:...:||..|..||||||.|:::|..|||
Mosquito   645 NLVDWWQSDTKTAYLEKARCIIEQYGNYTEPNVKLNLNGINTQGENIADNGGIKEAYYAYR---- 705

  Fly   613 QLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHY-WKGLSDVHTFDQFRVLGVLSN 676
            :..|..|.|:   .:|||:|:|||:|:|..||.:||.|..|.. .:..:.||:..||||||.:||
Mosquito   706 RWTEKNGPEQ---RLPGLNLSPEQMFWLSAAQTWCSVYRPETMKMRITTGVHSPGQFRVLGPMSN 767

  Fly   677 SEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ..:|...:||.|||.|.|..| |.:|
Mosquito   768 MHEFAKDFNCPVGSPMNPEHK-CEVW 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	190/715 (27%)
Nep2	XP_061497288.1	None