Protein Alignment Nepl12 and Nep1

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_553645.4
• Gene: Nep1 / 1279203
• VectorBaseID: AGAMI1_011171
• Length: 869
• Species: Anopheles gambiae
• Alignment Length: 725
• Identity: 195/725 - (26%)
• Similarity: 326/725 - (44%)
• Gaps: 138/725 - (19%)

  Fly    57 AEFMKSYMNQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEA 121
            |..:.:.|:::.:||::|:::|||.:..:   ...|..||::.  |:.::...:|.:.:..|.|.
Mosquito   204 ASSLLAAMDRTADPCKDFFQFACGTWNKM---HVIPEDRSSIS--TFEVLADQQQAILKGVLEEP 263

  Fly   122 LNVSSELAV--AQRFYNACLGANLHPFNAAD-PAYLSLIRSIGGFPAVDGDAWKASNFNWINMSA 183
            :|.....|.  |:.||.:|:  ||......| .|....::.:||:|.::.        ||...|.
Mosquito   264 VNKEDNRATKKAKAFYKSCM--NLEQIRLLDVQALRKSLKKLGGWPVIEK--------NWTVPST 318

  Fly   184 ---HL-----ANYGANGLIRETLQLRYPFEPYTKLPELGFDHIIVHEENISRNTTRAFRL----- 235
               ||     ..|...||:          |.|     :|.|     ::|.|.|..:..:|
Mosquito   319 SIEHLLGKLTGEYDEPGLV----------ELY-----VGAD-----DKNSSMNIIQVDQLLLALP 363

  Fly   236 -----NEERMHGYLRAF-----------GLPEDRIREAIAGVFAF-WRDALEIPPQCEVFDPYRI 283
                 .:|...|.::|:           |..:|:..|.:..:..| .|.|....|:.:..|...|
Mosquito   364 SRDYYLKESSEGDMKAYHRYMTQIAILMGADKDKAAEELQRIVEFEVRLANATLPEADRHDTSAI 428

  Fly   284 ---------KRVFPQSEYYYNISWS----------GLHSTNKL--FCDFYYVELDKVCA-RHRKA 326
                     :|..||      |:|.          .||....:  :...|.|||.|:.. ..|:.
Mosquito   429 YTKITLPELQRRVPQ------INWKEYLQTTLGTVALHPNESIVSYAMPYLVELGKILRDTDRRI 487

  Fly   327 VANYLAMKLL---------------YRFDPKLKAPRYQRN---YCSVTLYQSMRFLFNKLYMANN 373
            |.||...:|:               ..|..||...:.:||   .|.....:.:......|::.:|
Mosquito   488 VHNYAIWRLVMSIMTHMIDDYQKERVEFRRKLLGIQSERNRWSQCVEWTNKKLGMAVGALFIRDN 552

  Fly   374 FSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREI 438
            |::..:.....|:..:|::..:.|.|.||:|.|:||.|..|...:..||| :.|      |:...
Mosquito   553 FNQESKETALTMIHTIREAFNELLADIDWMDDETRAVAKEKADAMNERIG-YPD------ILTNA 610

  Fly   439 NSLKVIEDRYAETNIN----LQHLVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPD-NS 498
            :.|   |..|....|:    |::::..:...:.|:.|.|.......|..|...|...:|.|: |.
Mosquito   611 DEL---EKEYVNLTIHGGLFLENILSILKWEAERNLQLLRKPVDKNKWATEPAVVNAFYNPNKND 672

  Fly   499 INVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALED 563
            |...||:::|..|.::.|.||.:|.:|.::|||:.||||.....||.:|:|....:..:.:...:
Mosquito   673 IVFPAGILQPLFYSQNFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKDGNMMQWWNNATIKTFRE 737

  Fly   564 RAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMP 628
            ||:|.:|.|.:|::.|:...::|:.|..||||||.||:|   :||::|:.:.:| |.|   ..:|
Mosquito   738 RAQCIIDQYSRYKIDEVGLYMDGRMTQGENIADNGGLKQ---SYRAYRKWVSQH-GSE---PDLP 795

  Fly   629 GLDLTPEQLFFLGFAQLFC-SHYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGM 692
            ||::|.:|||||.:||::| |...|:...|..|.||:....||:|.||||.||..||.|.:||.|
Mosquito   796 GLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSSVHSPGIIRVIGPLSNSRDFAEAYRCPLGSPM 860

  Fly   693 RPGAKTCRLW 702
            .|.:| |.:|
Mosquito   861 NPVSK-CSVW 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	191/710 (27%)
Nep1	XP_553645.4	None