Protein Alignment Nepl12 and Nep3

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_317711.2
• Gene: Nep3 / 1278166
• VectorBaseID: AGAMI1_011685
• Length: 789
• Species: Anopheles gambiae
• Alignment Length: 790
• Identity: 188/790 - (23%)
• Similarity: 325/790 - (41%)
• Gaps: 152/790 - (19%)

  Fly     5 SLKLISLMLLWVIVAAVLTDCEARSLVDRSE-NSDSNGSSTNRSAAEYQLQEYAEFMKS----YM 64
            ||..:|::|: |:::::|.....|.|..|.. .||..|.......    |.::..|..|    .:
Mosquito    60 SLLALSIILI-VVLSSLLASDTTRILHVRPHVGSDPFGVDEQLPC----LNQHCIFAASEILHSI 119

  Fly    65 NQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSEL- 128
            :.||:||::||.::|..:....|   .|..:|..|            |.|:::....|.:.:.|
Mosquito   120 DWSVDPCDDFYAFSCNQWIRNNP---IPEGKSMWG------------LFGKLEQQNQLVLKNALE 169

  Fly   129 -----------AVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGF------PAVDGDAWKASN- 175
                       ..|:.:|.:||..:.............|:|.|||:      ...|...|....
Mosquito   170 RPLAEFKSKAEKKAKLYYQSCLDEDETMEKLGAEPLQKLLRQIGGWNVTANASGFDVQRWSLQRT 234

  Fly   176 -------------FNWI------NMSAHLANYGANGLIRETLQLRYPF--------------EPY 207
                         |.|.      |.|.|:......||   ||..|..:              |..
Mosquito   235 LQTLQIRYNMGGLFGWAVGEDDRNSSKHIIQIDQGGL---TLPSRDNYLNKTANAKILTAYLEYM 296

  Fly   208 TKLPE-LGFD---------HIIVHEENISRNTT-RAFRLNEERMHGYLRAFGLPEDRIREAIAGV 261
            ||:.. ||.|         .:|..|..::..|| :..|.:||.::..:....|.|       ...
Mosquito   297 TKVSVLLGADETDARRQMLEVIEFETRLANITTPQDMRRDEETLYHPMTLAMLQE-------KAP 354

  Fly   262 FAFWRDALEIPPQCEVFDPYR-IKRVFPQSEYYYNISWSGLHSTNKLFCDFYYVELDKVCARHRK 325
            |..|::..|        :.:| ::|...:.|.....:...|...|.|..::...:..|:
Mosquito   355 FINWQEHFE--------EAFRLVRRKITEKERVVVYAPEYLEKLNILMKEYTSTDEKKI------ 405

  Fly   326 AVANYLAMKLLYRFDPKL-KAPR--YQR---------------NYCSVTLYQSMRFLFNKLYMAN 372
            .:.|||..:.:......| ||.|  |:.               .||.......:.|....:::.:
Mosquito   406 ILNNYLVWQTVRTLTACLSKAFRDAYKGLRKALMGSDGGEELWRYCVSDTSNVLGFAVGAMFVRD 470

  Fly   373 NFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDAL-SDRIIR 436
            .|....:.:..||:.::|.:.::..::..|:|||:|..|:.|...|...|| |.|..| .:.:.|
Mosquito   471 VFHGDSKPQAEEMINQVRDAFKENFKNLGWMDAETRRLAVEKADAISDMIG-FPDYILYPEELDR 534

  Fly   437 EINSLKVIEDRYAETNINLQHLVVQINRFS-SRHFQELTNDTKPQKI-LTGLQVGAGYYTP-DNS 498
            :...|.:....|.:.|||       .|.:| .::.::|.......|. :|...|.| |||| .|.
Mosquito   535 KYQDLNIDPKTYFDNNIN-------YNIYSLKKNLEKLDQPVNKTKWGMTPPTVNA-YYTPTKNQ 591

  Fly   499 INVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALED 563
            |...||:::.|.:......||.:|.:|.::||||.|.||.....:|..|::....:..:.:..::
Mosquito   592 IVFPAGILQNPFFDIKNSKSLNYGAMGVVMGHELTHAFDDQGREYDKYGNLHQWWNNQTIERFKN 656

  Fly   564 RAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMP 628
            :.||:...|..|::.  .:.:|||.|:.||||||.||:.|..||.::.:.  .:...:.:  .:|
Mosquito   657 QTECFNQQYSAYRIN--GKTINGKQTMGENIADNGGLKAAFHAYINNEKN--SYTDTDTL--PLP 715

  Fly   629 GLDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGM 692
            |:::|..||||:.|||::||...:|.....: .|.|:..::||:|.|||.::|...::|.:|:||
Mosquito   716 GVNMTHRQLFFVSFAQVWCSAVTDETTTLQIEKDSHSPPKYRVIGPLSNLKEFSDTFHCPLGTGM 780

  Fly   693 RPGAKTCRLW 702
            .|..| |.:|
Mosquito   781 NPIEK-CVVW 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	170/718 (24%)
Nep3	XP_317711.2	None