Protein Alignment Nepl12 and Nep4

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_061501026.1
• Gene: Nep4 / 1273777
• VectorBaseID: AGAMI1_013990
• Length: 1007
• Species: Anopheles gambiae
• Alignment Length: 830
• Identity: 217/830 - (26%)
• Similarity: 344/830 - (41%)
• Gaps: 199/830 - (23%)

  Fly    31 VDRSE------------NSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEPCENFYEYACGNYR 83
            |:|||            |.|.:...:.|:|       ....||.||:...:||::||:|||||:
Mosquito   219 VERSEQLPRVRRSVGWMNDDRSSPESVRAA-------QVAIMKQYMDPDADPCDDFYQYACGNW- 275

  Fly    84 NVKPDRYSPGSRSNLGDVTYTLID-----ITEQLL------GRMDLAEALN-------------- 123
                ||.:|..:......|:.|:.     :.:|||      |.:|:..||:
Mosquito   276 ----DRVNPIPKDKAALDTFELLRESLDLVLKQLLLEGEPAGLLDVENALSTVRSQPDGTKKSTS 336

  Fly   124 ------------------------------------------VSSELAV---------------- 130
                                                      |.::|.:
Mosquito   337 TTTTAASAGWPTTTVTGGPAQQQLHRVRKRGRAENRNRSGRAVQNKLIIRSAQVKRVRRKRELLI 401

  Fly   131 -------AQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANY 188
                   |:..:.:|:...|......:| ..:|:.|:||:|.::...|..|:|:|:|::|.|..|
Mosquito   402 NDDAEMKARHLFVSCMNYELIERRGLEP-LRTLLHSLGGWPVLEPHTWDESSFDWLNLTAALRRY 465

  Fly   189 GANGLIRETLQLRYPFEPYTKLPEL-GFDHIIVHEENISRN-TTRAFRL---NEERMHGY----L 244
            ..:.||.|.:.           |:: ..|..||..:..|.. .||.:.|   |.:.:..|    |
Mosquito   466 NNDVLIVEWVG-----------PDIKNSDENIVQFDQTSLGLPTRDYYLQPGNRKYLEAYRQFML 519

  Fly   245 RAFGL---PEDRIREAIAGVFAFWRDALEIPPQCE----VFDPYRIKRVFPQSEYYYNISWSGLH 302
            ...||   |.|..|:|...:..|......|....|    |...||...:....|....|:|:  |
Mosquito   520 EVIGLLDVPADTARQATDEMIEFETQLANITSTPEERNNVSTLYRKLMLDQLQEEVPQINWT--H 582

  Fly   303 -------------STNKLFCDFYYVEL-DKVCARHRKAVANYLAMKLL---------------YR 338
                         |...:|...|..:| :.:.....:.|||||..:.:               .|
Mosquito   583 YLTIVTERPVNGSSFVVMFAMSYMRDLVELIDQTEPRIVANYLLWRFVRHRINNLDDRFLGAKQR 647

  Fly   339 FDPKL-----KAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALE 398
            |...|     ..||::.  |...:..:|......:::...|.|..:.:...|..||:.:.|:.|.
Mosquito   648 FSNALFGRERNPPRWKN--CVTQVNANMGMAVGAMFVRRYFDENSKRDTLTMTHELQDAFREILG 710

  Fly   399 DADWLDAESRARALLKESRIQPRIGSFQDDALS-DRIIREINSLKVIEDRYAETNIN-LQHLVVQ 461
            ...|:|..:|..|..|.:.:..||| :.|..|. :::.....:|::..|||.|..:| |.|
Mosquito   711 RTGWIDMATRQLAEQKVNAMSLRIG-YPDFILDPEQLSARYATLEIHPDRYFENTLNVLSH---- 770

  Fly   462 INRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPD-NSINVMAGVVEPPIYQRHLPISLKFGTLG 525
            |.|.......:..|.|...   |...|...||:.: |.|...||:::||.|.||||.::.:|.:|
Mosquito   771 IRRTDQEKLGQPVNKTAWH---TAPAVVNAYYSRNKNQIMFPAGILQPPFYHRHLPKAINYGGIG 832

  Fly   526 FIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTL 590
            .::||||.||||.....||.:|::....|:.:.:...:||.|.::.||:|::.|:..:::|:.|.
Mosquito   833 VVIGHELTHGFDDKGRLFDRDGNLYRWWSDRAIEEFHERAACLVEQYGRYRIAEVDVQLDGENTQ 897

  Fly   591 DENIADNSGLRQALTAYRSHRQQLLEHPGQERISDA--MPGLDLTPEQLFFLGFAQLFCSHYEEE 653
            .||||||.|::||..||    .:.|......|:.:|  :|||::|..|||||.|||::|.....|
Mosquito   898 GENIADNGGIKQAFLAY----SKWLAAQTDRRVLEAETLPGLNVTRTQLFFLNFAQIWCGAMRPE 958

  Fly   654 HYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            .....| :.||:..:|||:|.|||||||...|:|.|||.|.|..| |.:|
Mosquito   959 ATRNKLKTAVHSPGRFRVIGTLSNSEDFAREYHCPVGSTMNPPGK-CSVW 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	203/777 (26%)
Nep4	XP_061501026.1	None