Protein Alignment Nepl12 and Eef1ece2

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_808810.1
• Gene: Eef1ece2 / 110599584
• MGIID: 6121518
• Length: 910
• Species: Mus musculus
• Alignment Length: 789
• Identity: 211/789 - (26%)
• Similarity: 333/789 - (42%)
• Gaps: 170/789 - (21%)

  Fly     3 HESLKLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQS 67
            |..|:|: |..|.:::||:|..|.....|.|.       .:.:....|..::...:.::| :::.
Mouse   203 HTQLELV-LAGLILVLAALLLGCLVALWVHRD-------PAHSTCVTEACIRVAGKILES-LDRG 258

  Fly    68 VEPCENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAV 130
            |.||::||:::||.:  ||..|:..|..:..|      :|.|..:.:|..:......|.|||
Mouse   259 VSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFN------SLWDQNQAILKHLLENTTFNSSSE--- 314

  Fly   131 AQR----FYNACLGANLHPFNAADPAYLSLIRSIGGF---------------PAVDGDAWKASNF 176
            |:|    ||.:||.:.......|.| ...||..|||:               .||.| .::|:.|
Mouse   315 AERKTRSFYLSCLQSERIEKLGAKP-LRDLIDKIGGWNITGPWDEDSFMDVLKAVAG-TYRATPF 377

  Fly   177 NWINMSAHLANYGANGLIRETLQLRYPFEPYTKLPELGFDHIIVHEENISRNTTRAFRLNEERMH 241
            ..:.:||...:..:|.:..:...|..|...|                .::|..      ||:.:.
Mouse   378 FTVYVSADSKSSNSNIIQVDQSGLFLPSRDY----------------YLNRTA------NEKVLT 420

  Fly   242 GYLRAF--------GLPEDRIREAIAGVFAFWRDALEIP------PQCEVFDPYRIKRVFPQSEY 292
            .||...        |.|.. .||.:..|.     .|||.      ||.:..|..:|
Mouse   421 AYLDYMVELGVLLGGQPTS-TREQMQQVL-----ELEIQLANITVPQDQRRDEEKI--------- 470

  Fly   293 YYNISWSGLHSTNKL-----FCDF-------------------YYVELDKVCARHRKAVA-NYLA 332
            |:.:|.|.|.:....     |..|                   |..::.::..|...::. |||.
Mouse   471 YHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLI 535

  Fly   333 MKLL--------YRFD-------------PKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSE 376
            ..|:        .||:             .|...||:|.  |......::.|....|::...|..
Mouse   536 WNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQT--CISNTDDALGFALGSLFVKATFDR 598

  Fly   377 AKRLEMSE-MVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREI-N 439
            ..: |::| |:.|:|.:..:.|.|..|:|.::|..|..|...|...|| |.|..|..:.:.:: :
Mouse   599 QSK-EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIG-FPDFILEPKELDDVYD 661

  Fly   440 SLKVIEDRYAETNINLQH-----LVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPDNSI 499
            ..:|.||.:.:..:||.:     :..|:.:..||....:|..|          |.|.|....|.|
Mouse   662 GYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQT----------VNAYYLPTKNEI 716

  Fly   500 NVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDR 564
            ...||:::.|.|..:.|.:|.||.:|.::||||.|.||.....:|..|::.......|..|.::.
Mouse   717 VFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNH 781

  Fly   565 AECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPG 629
            ..|..:.|.:|||.  ..|:||..||.||||||.||:.|..||::   .|.:| |:|:   .:|.
Mouse   782 TACMEEQYSQYQVN--GERLNGLQTLGENIADNGGLKAAYNAYKA---WLRKH-GEEQ---PLPA 837

  Fly   630 LDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMR 693
            :.||..||||:||||::||....|...:|| :|.|:..:|||||.||||.||...:.|.|||.|.
Mouse   838 VGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMN 902

  Fly   694 PGAKTCRLW 702
            || :.|.:|
Mouse   903 PG-QLCEVW 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	196/720 (27%)
Eef1ece2	NP_808810.1	UbiG	46..>128	CDD:441829
		M13	259..908	CDD:341056	196/720 (27%)