DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl12 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_055508.3	Gene:	EEF1AKMT4-ECE2 / 110599583	HGNCID:	53615	Length:	883	Species:	Homo sapiens

Alignment Length:	727	Identity:	203/727 - (27%)
Similarity:	308/727 - (42%)	Gaps:	159/727 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 MNQSVEPCENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSS 126
            :::.|.|||:||:::||.:  ||..||..|..:..|      :|.|..:.:|..:......|.||
Human   228 LDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFN------SLWDQNQAILKHLLENTTFNSSS 286

  Fly   127 EL-AVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANYGA 190
            |. ...||||.:||.........|.| ...||..|||: .:.| .|...||..: :.|....|.|
Human   287 EAEQKTQRFYLSCLQVERIEELGAQP-LRDLIEKIGGW-NITG-PWDQDNFMEV-LKAVAGTYRA 347

  Fly   191 NGLIRETLQLRYPFEPYTKLPELGFDHIIVHEENISRNT-------------TRAFRLNEERMHG 242
            .           ||  :|         :.:..::.|.|:             :|.:.||......
Human   348 T-----------PF--FT---------VYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEK 390

  Fly   243 YLRAF------------GLPEDRIREAIAGVFAFWRDALEIP------PQCEVFDPYRIKRVFPQ 289
            .|.|:            |.|.. .||.:..|.     .|||.      ||.:..|..:|
Human   391 VLTAYLDYMEELGMLLGGRPTS-TREQMQQVL-----ELEIQLANITVPQDQRRDEEKI------ 443

  Fly   290 SEYYYNISWSGLH----STNKL-FCDF-------------------YYVELDKVCARHRKAVA-N 329
               |:.:|.|.|.    |.:.| |..|                   |..::.::..|...::. |
Human   444 ---YHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNN 505

  Fly   330 YLAMKLLY--------RFD-------------PKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANN 373
            ||...|:.        ||:             .|...||:|.  |......::.|....|::...
Human   506 YLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQT--CISNTDDALGFALGSLFVKAT 568

  Fly   374 FSEAKRLEMSE-MVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIRE 437
            |....: |::| |:.|:|.:..:||....|:|.::|..|..|...|...|| |.|..|..:.:.:
Human   569 FDRQSK-EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIG-FPDFILEPKELDD 631

  Fly   438 I-NSLKVIEDRYAETNINLQH-----LVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPD 496
            : :..::.||.:.:..:||.:     :..|:.:..||....:|..|          |.|.|....
Human   632 VYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQT----------VNAYYLPTK 686

  Fly   497 NSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQAL 561
            |.|...||:::.|.|.|:.|.:|.||.:|.::||||.|.||.....:|..|::.......|..|.
Human   687 NEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAF 751

  Fly   562 EDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDA 626
            .:...|..:.|.:|||.  ..|:||:.||.||||||.||:.|..||::   .|.:| |:|:   .
Human   752 RNHTACMEEQYNQYQVN--GERLNGRQTLGENIADNGGLKAAYNAYKA---WLRKH-GEEQ---Q 807

  Fly   627 MPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGS 690
            :|.:.||..||||:||||::||....|...:|| :|.|:..:|||||.||||.||...:.|.|||
Human   808 LPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGS 872

  Fly   691 GMRPGAKTCRLW 702
            .|.|| :.|.:|
Human   873 PMNPG-QLCEVW 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	201/719 (28%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160
		Methyltransf_25	62..>128	CDD:316196
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	88..89
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	113..114
		M13	232..881	CDD:189000	201/719 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850