DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl12 and Ece2

DIOPT Version :9

Sequence 1:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_647454.2	Gene:	Ece2 / 107522	MGIID:	1101356	Length:	763	Species:	Mus musculus

Alignment Length:	789	Identity:	211/789 - (26%)
Similarity:	333/789 - (42%)	Gaps:	170/789 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HESLKLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQS 67
            |..|:|: |..|.:::||:|..|.....|.|.       .:.:....|..::...:.::| :::.
Mouse    56 HTQLELV-LAGLILVLAALLLGCLVALWVHRD-------PAHSTCVTEACIRVAGKILES-LDRG 111

  Fly    68 VEPCENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAV 130
            |.||::||:::||.:  ||..|:..|..:..|      :|.|..:.:|..:......|.|||
Mouse   112 VSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFN------SLWDQNQAILKHLLENTTFNSSSE--- 167

  Fly   131 AQR----FYNACLGANLHPFNAADPAYLSLIRSIGGF---------------PAVDGDAWKASNF 176
            |:|    ||.:||.:.......|.| ...||..|||:               .||.| .::|:.|
Mouse   168 AERKTRSFYLSCLQSERIEKLGAKP-LRDLIDKIGGWNITGPWDEDSFMDVLKAVAG-TYRATPF 230

  Fly   177 NWINMSAHLANYGANGLIRETLQLRYPFEPYTKLPELGFDHIIVHEENISRNTTRAFRLNEERMH 241
            ..:.:||...:..:|.:..:...|..|...|                .::|..      ||:.:.
Mouse   231 FTVYVSADSKSSNSNIIQVDQSGLFLPSRDY----------------YLNRTA------NEKVLT 273

  Fly   242 GYLRAF--------GLPEDRIREAIAGVFAFWRDALEIP------PQCEVFDPYRIKRVFPQSEY 292
            .||...        |.|.. .||.:..|.     .|||.      ||.:..|..:|
Mouse   274 AYLDYMVELGVLLGGQPTS-TREQMQQVL-----ELEIQLANITVPQDQRRDEEKI--------- 323

  Fly   293 YYNISWSGLHSTNKL-----FCDF-------------------YYVELDKVCARHRKAVA-NYLA 332
            |:.:|.|.|.:....     |..|                   |..::.::..|...::. |||.
Mouse   324 YHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLI 388

  Fly   333 MKLL--------YRFD-------------PKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSE 376
            ..|:        .||:             .|...||:|.  |......::.|....|::...|..
Mouse   389 WNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQT--CISNTDDALGFALGSLFVKATFDR 451

  Fly   377 AKRLEMSE-MVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREI-N 439
            ..: |::| |:.|:|.:..:.|.|..|:|.::|..|..|...|...|| |.|..|..:.:.:: :
Mouse   452 QSK-EIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIG-FPDFILEPKELDDVYD 514

  Fly   440 SLKVIEDRYAETNINLQH-----LVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPDNSI 499
            ..:|.||.:.:..:||.:     :..|:.:..||....:|..|          |.|.|....|.|
Mouse   515 GYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQT----------VNAYYLPTKNEI 569

  Fly   500 NVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDR 564
            ...||:::.|.|..:.|.:|.||.:|.::||||.|.||.....:|..|::.......|..|.::.
Mouse   570 VFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNH 634

  Fly   565 AECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPG 629
            ..|..:.|.:|||.  ..|:||..||.||||||.||:.|..||::   .|.:| |:|:   .:|.
Mouse   635 TACMEEQYSQYQVN--GERLNGLQTLGENIADNGGLKAAYNAYKA---WLRKH-GEEQ---PLPA 690

  Fly   630 LDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMR 693
            :.||..||||:||||::||....|...:|| :|.|:..:|||||.||||.||...:.|.|||.|.
Mouse   691 VGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMN 755

  Fly   694 PGAKTCRLW 702
            || :.|.:|
Mouse   756 PG-QLCEVW 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:189000	196/720 (27%)
Ece2	NP_647454.2	M13	112..761	CDD:189000	196/720 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841094
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950