Protein Alignment Nepl12 and kel

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_068070210.1
• Gene: kel / 101882278
• ZFINID: ZDB-GENE-110411-118
• Length: 793
• Species: Danio rerio
• Alignment Length: 757
• Identity: 157/757 - (20%)
• Similarity: 263/757 - (34%)
• Gaps: 212/757 - (28%)

  Fly    57 AEFMKSYMNQSVEPCENFYEYACG--------NYRNVKPD----------------------RYS 91
            :|.....|:....||: ::.:|||        :.:.||.:                      ..|
Zfish   121 SEHFSVAMDPFSRPCD-YFLFACGAGGSSTNRDRQRVKGEVNKHSEVRTRGLIEMRRGTDGWSKS 184

  Fly    92 PGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAVAQRFYNACLGANLHPFNAADPAYLSL 156
            .|......|....|:...:::|...|  ||:::.:....|:.|:.:|:.|.......::| :|:|
Zfish   185 DGQLKTFPDRQTALLTAIKEILEAPD--EAVSMGAAEQKAKNFFKSCMNAESREKMGSEP-FLTL 246

  Fly   157 IRSIGGFPAVDGDAWKASNFNWINMSAHLANYGANGLIRETLQLRYPF-------EP-------- 206
            ::.:||: ||.| .|..::|| ..::..:..|..           :||       ||
Zfish   247 LQQLGGW-AVSG-VWNQTDFN-STLALLMGQYST-----------FPFFNVYVGPEPSEEQSASN 297

  Fly   207 --YTKLPELGFDHIIVHEENI--SRNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWRD 267
              |.::.|..|...|......  ::..||..|........||...|:|.||..:. .|:|.....
Zfish   298 RHYIQIDEPHFQFPIEWNSKTQKAKANTRYLRPFYSACGQYLVLLGVPSDRTTQH-CGLFVSLST 361

  Fly   268 ALEIPPQCEVFD-PYRIKRVFPQSEYYYNISWSGLH----STNKLFC-------------DF--- 311
            .|.:    ..|. |||:.    |...|...:...|.    :.:.|.|             |.
Zfish   362 TLAV----ATFPLPYRLS----QKLLYRRTTIQELQTLAPAVDWLACLQATFQPLLISKSDIVLV 418

  Fly   312 ----YYVELDKVC----ARHR----KAVANYLAMKLLYRFDPKLKAPRYQ--RNYCSVT------ 356
                |.:.:.|..    .:|.    ..:..|:...||....|.|.:..:|  |||...|
Zfish   419 HNLPYIIHMSKTIHLWQVQHELMGTGPLNTYMIFSLLQTLIPALDSRFFQIMRNYSIATGDTQEM 483

  Fly   357 ------LYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKE 415
                  :.|:.|.....|..|.....|:: |..|:::::..||:|.|.|..|.|.:.....|.|.
Zfish   484 PHWWRCVQQTERGFDTLLSHAIREKHAQK-EAEELIQDVYSSLKKKLTDLSWRDEKESDFILNKI 547

  Fly   416 SRIQPRIGSFQDDALSDRIIREINSLKVIEDRYAETNINLQHLVVQINRFSSRHFQELTNDTKPQ 480
            :.:.|||.:            ..|:|.     |.|.|...:.:::....|.|.:.|.|..:.|.:
Zfish   548 NSLNPRIST------------NTNNLS-----YTELNHLYEKVILNEEDFFSNYLQILLLEQKSR 595

  Fly   481 -KILT-GLQVGAGYYTP---DNSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTS 540
             ::|: |.|......||   .|.|.|..|:...|.:....|.:|.:||||.::..:|:|
Zfish   596 ARLLSLGTQTEGLSMTPFISGNDIIVPVGMFVSPFFHSSYPRALNYGTLGSLMAKDLLH------ 654

  Fly   541 SYFDGNGHMESLLSEISQQALEDRAE--CYMDYY----------GKYQVPEISRRVNGKTTLDEN 593
                      .||.:|..:|.....|  |...:|          ..:.:|...::        |.
Zfish   655 ----------LLLPDIYTKAKNPETESLCVWSHYLSVTKGPGWGDAFYLPSSKQQ--------EV 701

  Fly   594 IADNSGLRQALTAYR-SHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWK 657
            ....|.|:.||.||: |.::.|.:        .::||....  .||...|.::.|
Zfish   702 WVQYSALQVALDAYKMSFKRYLAD--------SSLPGFSYV--HLFLSSFTKVTC---------- 746

  Fly   658 GLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTC 699
               |...:.:|..|     ...|.....|| .||:.|...||
Zfish   747 ---DTDAYREFMPL-----EPSFLVTVLCS-NSGLCPKPLTC 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	155/746 (21%)
kel	XP_068070210.1	GluZincin	133..>654	CDD:472708	120/565 (21%)
		GluZincin	617..>755	CDD:472708	37/184 (20%)