Protein Alignment Nepl12 and mme

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_031758820.1
• Gene: mme / 101734885
• XenbaseID: XB-GENE-1011098
• Length: 746
• Species: Xenopus tropicalis
• Alignment Length: 721
• Identity: 184/721 - (25%)
• Similarity: 310/721 - (42%)
• Gaps: 122/721 - (16%)

  Fly    64 MNQSVEPCENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSS 126
            |:.:.:||.:||:||||.:  :|..||.   ...||..|:..|.|::.        |.:||...|
 Frog    66 MDAATDPCNDFYQYACGGWLKKNRIPDN---NIVSNTFDILRTDIEVV--------LKDALEKES 119

  Fly   127 -----ELAVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGFP-AVD------GDAWKASNFNWI 179
                 .:...:.||.:|:...:.......| .:..:.::..:| |||      |..|.|..
 Frog   120 ADDIPAIKKVKTFYKSCIDETIKNLRKGGP-LIKTLPALYDWPIAVDNWETRYGLVWSAQE---- 179

  Fly   180 NMSAHLANYGANGLIR----ETLQLRYPFEPYTKLPELGF---DH-----------IIVHEENIS 226
            :::..:..||.:|||.    |.|.....:..:...|.||.   |:           :...|:.:|
 Frog   180 SIAGFITKYGQSGLINVYVSEDLTNSSTYILHIDQPGLGLPSKDYYDCKGTSEIACLAYMEQMVS 244

  Fly   227 RNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCEV----FDPYR----- 282
                .|..:.:|      |...:.||:|...:..||...|:..:.....|:    .|.|:
 Frog   245 ----VAMLIRKE------RNLTINEDKILSEMEKVFKLEREIAKAEASEEIRENLNDIYKKMTLS 299

  Fly   283 -IKRVFPQSEYYYNISWSGL--------------HSTNKLFCDFYYVELDKVCARHRKAVANYLA 332
             |.:.:|......||:|..|              :....|.|..|..:|..:.....:.:.|||.
 Frog   300 GIAKTYPLKMNDQNINWLKLINAIISPGGVSIEENEQVALICSDYLKKLRFLNKYKARELQNYLG 364

  Fly   333 ----------MKLLYR-FDPKLKAPRYQR-------NYCSVTLYQSMRFLFNKLYMANNFS-EAK 378
                      :.|.|: ....||...|..       ..|...|..:|.....:||:....| :.:
 Frog   365 WRYILSAINDLSLEYKNTGIHLKKALYGNAAEGSDWQTCVTYLNDNMEDAIGRLYLKETLSADIE 429

  Fly   379 RLEMSEMVRELRKSLRKA----LEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREIN 439
            .:::.:.|:|:...:|:|    ||:.||:|.:::.||..|.:.|..|| :|.:|.:.|..:.|
 Frog   430 HVKVKDKVKEIIAEIRRAFLEMLEEMDWMDEDTKKRAARKVASINERI-AFSEDIMDDFKLNE-- 491

  Fly   440 SLKVIEDRYAETNINLQHLVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPDNSINVMAG 504
            ....:|.|..|...|.|..:..:.:..:...::..|  |.:.:.....|.|.|....|.|...||
 Frog   492 GYSELEFRVDELFENKQKYIEFVQKKMTSRLRKQVN--KNEWVPGPAHVNAFYSLTYNEIVFPAG 554

  Fly   505 VVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYM 569
            :::.|.:....|.:|.:|.:|.|:|||:.||||.....||.:|::.:..:..|.....:.::|::
 Frog   555 ILQTPFFSSSQPSALNYGGIGMIIGHEITHGFDNRGCNFDEHGNLVNWWTNASMMNFSNLSQCFV 619

  Fly   570 DYYGKYQVPEI-SRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLT 633
            :.||.|...|. .:.:||.:||.|||:||.|:|   .|||:.:..:..|    :..|.:||:||.
 Frog   620 NQYGNYSWDEAGGQYLNGISTLGENISDNGGIR---GAYRAFKNYVKSH----KEDDLLPGIDLD 677

  Fly   634 PEQLFFLGFAQLFCSHYEEEHYWKGL--SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGA 696
            .:||||:.|.|::|..:..| |...|  :..||...|||:|.|.||.:|..|::|...:.|.|..
 Frog   678 SDQLFFISFGQIWCGMHRPE-YAATLIKTGSHTPGIFRVIGTLQNSPEFSKAFSCCNNAYMNPAV 741

  Fly   697 KTCRLW 702
            | |:||
 Frog   742 K-CKLW 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	180/713 (25%)
mme	XP_031758820.1	M13	71..744	CDD:341056	180/712 (25%)