Protein Alignment Nepl12 and ecel1

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_012818808.2
• Gene: ecel1 / 100496473
• XenbaseID: XB-GENE-989944
• Length: 764
• Species: Xenopus tropicalis
• Alignment Length: 733
• Identity: 170/733 - (23%)
• Similarity: 302/733 - (41%)
• Gaps: 157/733 - (21%)

  Fly    57 AEFMKSYMNQSVEPCENFYEYACGNY---RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDL 118
            ::|:.:.::.::.||.:||.:|||.:   ..:..|:...|:.:.:|:.....:   |.||  :..
 Frog   102 SKFITNNIDPTISPCTDFYSFACGGWLRRHGIPEDKLIYGTIAAIGEQNEEKL---EHLL--LQP 161

  Fly   119 AEALNVSSELAVAQRFYNACLGANLHPFN--AADPAYLSLIRSIGGF--PAVDGDAWKASNFNWI 179
            ....:..|.....:.|:.:||  |:...:  .|.| .|.:|...||:  |......|   :||.:
 Frog   162 VRRKHKGSAERKVKEFFKSCL--NMRDIDRLGARP-MLQVIEDCGGWDLPEDPRTQW---DFNEL 220

  Fly   180 -----------------------NMSAHLANYGANGLI--RETLQL-----------RYPFEPYT 208
                                   |.|.::.....:||.  ..||.|           .|.....|
 Frog   221 LYKTQGVYSTAVFFSMTVSLDDKNSSRYIIRIDQDGLTLPERTLYLGQDEESIKVLEAYKVFMQT 285

  Fly   209 KLPELGFDHI------IVH-EENISRNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWR 266
            .|..||.:::      |:| |:::|..|...|                  |.:|..|:.::
 Frog   286 ILSLLGVENVQKKAEEILHLEQHLSNITISEF------------------DDMRRDISTMY---- 328

  Fly   267 DALEIPPQCEVFDPYRIKRVFPQSEYYYNISWSGLHSTNKLF--------------CDFYYVELD 317
            :.:.:.         :::::.|      :::|..|  .|::|              .|:.....:
 Frog   329 NKVTLA---------QLQQITP------HLNWKNL--LNRIFHTNFPEDEEVVVLATDYMQKVSE 376

  Fly   318 KVCARHRKAVANYLAMKL---------------LYRFDPKLKAPRYQRNYCSVTLYQSMR---FL 364
            .:.:.....:.||:..::               ::....:::....|.....|.|.|:.:   ..
 Frog   377 MIRSTPASVLHNYMLWRIVVVLSEHLSTPFRDAIHELSKEMEGSEKQAELTKVCLTQANKHFGMA 441

  Fly   365 FNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDA 429
            ...|::...||.:.:.::.::|..::..|...||:.||:|.|::..|..|...:...|| :.|..
 Frog   442 LGALFVEEYFSSSSKAKVQQLVENIKHILDYRLEELDWMDTETKQAAREKLKHMMVMIG-YPDVL 505

  Fly   430 LSDRIIREINSLKVIEDRYAETNINLQHLVVQINRFSSRHFQELTNDT---KPQKILTGLQVGAG 491
            |....:.:....:|.|..|.:..:|  .:...|.....|..||:....   .||.:       ..
 Frog   506 LQPESMDKEYEFEVNEKTYFKNILN--SIRYSIKMAVRRIRQEVDKSAWLLPPQAL-------NA 561

  Fly   492 YYTPD-NSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSE 555
            ||.|: |.:...||:::|.:|....|.||.:|.:|.|:||||.||:|.....:|.||:.....:|
 Frog   562 YYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDANGNPIQWWTE 626

  Fly   556 ISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQ 620
            .|......:|||.:|.|..:.|  .::||||:|||.|||||..||:.|..||    |:.:...|.
 Frog   627 DSYSKFLKKAECIVDLYENFTV--YNQRVNGRTTLGENIADLGGLKLAYYAY----QKWVRDNGP 685

  Fly   621 ERISDAMPGLDLTPEQLFFLGFAQLFC-SHYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAY 684
            ||   .:|.|..|.:||||:.|||.:| ....:..|.:.|:|.|..:.:||:|.:|..|:|...:
 Frog   686 ER---PLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVMGSVSQFEEFGRVF 747

  Fly   685 NCSVGSGMRPGAKTCRLW 702
            :|...|.|.|..| |.:|
 Frog   748 HCPRNSPMNPVHK-CSVW 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	167/718 (23%)
ecel1	XP_012818808.2	M13	113..762	CDD:341056	167/718 (23%)