Protein Alignment Nepl12 and phex

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_004911718.1
• Gene: phex / 100496470
• XenbaseID: XB-GENE-1012247
• Length: 750
• Species: Xenopus tropicalis
• Alignment Length: 755
• Identity: 186/755 - (24%)
• Similarity: 313/755 - (41%)
• Gaps: 144/755 - (19%)

  Fly    45 NRSAAEYQLQEY---------AEFMKSYMNQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGD 100
            ::....:|..||         |..::|.||.||:||::|::||||.:....|   .|...||.|.
 Frog    43 SKGLISFQKDEYCLTPECIEAAASIRSKMNLSVDPCDDFFQYACGGWIEENP---IPDDMSNYGI 104

  Fly   101 VTY--TLIDITEQLLGRMDLAEALNVSSELAVAQRFYNACLGANLHPFNAADPAYLSLIRSIGGF 163
            ..:  |.:|:..:.|....:::..: |..:...:.||.:|:.......:...|....|.:....:
 Frog   105 YPWLRTNVDLKLKALLEKPISKRRD-SEAIQKVKTFYISCMNETQIEEDDIKPILKILKQPSLRW 168

  Fly   164 PAVDGD-----AWKASNFNWINMSAHLAN-YGANGLIRETLQL--RYPFEPYTKLPELGFDHIIV 220
            |.::.:     .|....|:::...|.|.. |..:..:|..:.:  :.......||.:.... ::.
 Frog   169 PVLESNIGSDGKWSERKFSFLQTVADLRRLYSTSVFLRVYVAIDDKVSNNFILKLDQASLS-LLS 232

  Fly   221 HEENISRNT-TRAFR---------------LNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDAL 269
            ||:.:..:| .:.:|               .|:.|....::|....|.::.:            :
 Frog   233 HEDYLDNSTIAKKYRDALLEFMVDVAVLLGANKTRAETDMKALIELETKLAQ------------I 285

  Fly   270 EIPPQCEVFDPYRIKRVFPQSEYYYN-------------ISWSGLHSTNKLFCDF-YYVEL---- 316
            .:|.:...            ||..||             ..|.   |..|...|| .|.||
 Frog   286 TVPQENRT------------SEMMYNKMNISELSAMIPQFDWL---SYLKNIIDFNIYPELKNID 335

  Fly   317 --DKVCAR---------------HRKAVANYLAMKLLYRFDPKLK-------------------- 344
              :.|..|               .::.:||||..:|:|...|.|.
 Frog   336 LSENVIVRVPQHFKDLFNIIESEEKRTLANYLIWRLVYSRIPNLSRRFQYRQLEFARILLGTNSL 400

  Fly   345 APRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALE-DADWLDAESR 408
            |.|:.|  |...:..|:.:...||::..:|.|.|:..|.|:|..:|.:....|| :.||:|||::
 Frog   401 AGRWDR--CVNYVENSIPYPVGKLFVDAHFQEDKKDMMEELVDGIRWAFIDMLEKENDWMDAETK 463

  Fly   409 ARALLKESRIQPRIG----SFQDDALSDRIIREINSLKVIEDRYAETNINLQHLVVQINRFSSRH 469
            .:|..|...:..::|    .|.|..|::    :|..||..|..|....:...|.:.|.:.:..|.
 Frog   464 IKAKQKAVTVMAKVGYPEFLFNDTYLNE----DIKMLKFSESDYFGNVLQTLHFISQSDFYWLRR 524

  Fly   470 FQELTNDTKPQKILTGLQVGAGYYTPDNSINVMAGVVEPPIYQR-HLPISLKFGTLGFIVGHELI 533
                 |..|.:.......|.|.|....|.|...||.::.|.:.. ..|.||.:|.:|.|||||..
 Frog   525 -----NVPKKEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGVQYPRSLSYGAIGVIVGHEFT 584

  Fly   534 HGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNS 598
            ||||.....:|..|::.|..:..|::..:::..|.::.|..|...:....|.|..||.||||||.
 Frog   585 HGFDNNGRKYDKEGNLFSWWTSESEERFKNKTLCMVEQYNNYYWKQAGLHVKGMKTLSENIADNG 649

  Fly   599 GLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYE-EEHYWKGLSDV 662
            |:|::..|||...:.|  ..|:|.:  .:|||||...||||:.:|.:.|:.:. |....:.::.|
 Frog   650 GIRESFRAYRKWIEDL--RKGKEEM--LLPGLDLNNNQLFFISYAHVRCNSFRIESARDQIMNGV 710

  Fly   663 HTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            |:..||||:|.:||.|:|..|::|...|.|..||.:||:|
 Frog   711 HSPPQFRVIGAMSNFEEFHKAFSCPKDSKMNRGANSCRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	175/719 (24%)
phex	XP_004911718.1	M13	75..741	CDD:341056	172/712 (24%)