Protein Alignment Nepl12 and ece2

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_002935189.1
• Gene: ece2 / 100488407
• XenbaseID: XB-GENE-1011916
• Length: 766
• Species: Xenopus tropicalis
• Alignment Length: 769
• Identity: 210/769 - (27%)
• Similarity: 341/769 - (44%)
• Gaps: 151/769 - (19%)

  Fly    13 LLWVIVAAVLTDCEARSLVDRSEN---SDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEPCENF 74
            :|.|::...|.....:.:.|||.:   |::..|...|             :...:::.::||::|
 Frog    70 VLGVLLLGSLIALGVQQMTDRSRSLCLSEACVSVAGR-------------ILDSLDRGIDPCQDF 121

  Fly    75 YEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAV-AQRFYN 136
            |:|:||.:  ||..||..|..:..|      ::.|..:.:|..:......|.|||..: .||||.
 Frog   122 YQYSCGGWMRRNPLPDGRSRWNTFN------SIWDQNQAILKHILENATFNSSSEAEMKTQRFYL 180

  Fly   137 ACL---------------------GANLHPFNAADPAYLSLIRSIGG----------FPAVDGDA 170
            :||                     |.|:.. |.....::|:::::.|          |.:.|.
 Frog   181 SCLKEQRIEELRQKPLTDLIEKIGGWNISG-NWRGENFMSVLKTVSGTYRATPFFSVFVSADS-- 242

  Fly   171 WKASNFNWINMSA---------HLANYGANGLIRETLQLRY-----------PFEPYTKLPELGF 215
             |:||.|.|.:..         :..|..|||.:.:. .|:|           |.....::.:
 Frog   243 -KSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDA-YLQYMVSVGELLGGSPGSVDMQMTQ--- 302

  Fly   216 DHIIVHEENISRNTT--RAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCEVF 278
               |:..|.:..|.|  :..|.:||:::..:....|      :::|..|. |.|.|..     ..
 Frog   303 ---ILEFETLLANLTVPQDERRDEEKIYNRMTISEL------QSLAPAFD-WMDYLTF-----AL 352

  Fly   279 DPYRIKRVFP----QSEYYYNISWSGLHSTNKLFCDFYYV---------ELDKVCARHRKAVANY 330
            .|..:....|    ..||...:| ..:::|:.:..:.|.|         .||   :|..||....
 Frog   353 SPLDLNDTEPVVVYGKEYLQQVS-ELVNNTDPMLLNNYLVWNLVQKMSSSLD---SRFEKAQDKL 413

  Fly   331 LAMKLLYRFDPKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRK 395
            |  :.||. ..|...||:|.  |......::.|....|::.:.|.:..:....:|:.|:|.:...
 Frog   414 L--ESLYG-AKKSCTPRWQT--CLSNTDDTLGFALGSLFVKSTFDKNSKNIAEQMISEIRDAFEL 473

  Fly   396 ALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREI-NSLKVIEDRYAETNINLQHLV 459
            .|....|:|.::|..|..|...|...|| |.|..|..:.:.|: :..:|.||.:.:..:|..:
 Frog   474 TLGGLTWMDEKTRRAAKEKADAIYDMIG-FPDFILDTKELDEVYDGFEVSEDAFFQNMLNFYN-- 535

  Fly   460 VQINRFSSRHFQELTNDTKP----QKILTGLQVGAGYYTPD-NSINVMAGVVEPPIYQRHLPISL 519
                 ||::...|...  ||    |..:|...|.| ||.|: |.|...||:::.|.|....|.:|
 Frog   536 -----FSAKLMAEQLR--KPPNREQWSMTPQTVNA-YYLPNKNEIVFPAGILQAPFYAPTHPKAL 592

  Fly   520 KFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRV 584
            .||.:|.::||||.|.||.....:|.:|::.......|.:|.::|.||.::.|..|.|.  ..||
 Frog   593 NFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVN--GERV 655

  Fly   585 NGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSH 649
            ||:.||.||||||.||:.|..||:|   .|::| |:|:   .:||:.||..||||:||||::||.
 Frog   656 NGRQTLGENIADNGGLKAAYHAYKS---WLVKH-GEEK---QLPGVGLTNNQLFFVGFAQVWCSV 713

  Fly   650 YEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            ...|...:|| :|.|:..:|||:|.||||:||...:||..|:.|.|| |.|.:|
 Frog   714 RTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPG-KHCDVW 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	199/707 (28%)
ece2	XP_002935189.1	M13	115..763	CDD:341056	199/706 (28%)