Protein Alignment Nepl12 and ece1

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_031762312.1
• Gene: ece1 / 100485607
• XenbaseID: XB-GENE-1014218
• Length: 782
• Species: Xenopus tropicalis
• Alignment Length: 783
• Identity: 212/783 - (27%)
• Similarity: 331/783 - (42%)
• Gaps: 169/783 - (21%)

  Fly     6 LKLISLMLLWVIVAAVLTDCEARS--LVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSV 68
            |.|:.|:.|.:.:..:....:.|:  .|..||:..|..||..||                :::|.
 Frog    83 LVLVVLLSLGLFMCLLALSLQYRNSHRVCLSESCISVTSSILRS----------------LDRSA 131

  Fly    69 EPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRM-DLAEALNVSSELAV-- 130
            :||::||:|:||.:....|   .|...|..|    |..::.|.....| .|.|...:.:....
 Frog   132 DPCQDFYQYSCGGWIKGNP---VPDGHSRWG----TFNELWEHNQATMKHLLENSTIETNSTAER 189

  Fly   131 -AQRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANYGANGLI 194
             |||::.||:.........|.|.. .||:.:||: |:.| .|...||
 Frog   190 KAQRYFQACMNETKIEELGAKPLQ-DLIQKLGGW-AITG-PWDRDNF------------------ 233

  Fly   195 RETLQL---RYPFEPYTKLPELGFDHIIVHEENISRNT-----------TRAFRL----NEERMH 241
            :|||||   .|...|:..:      .:....:|.:.|.           :|.|.|    ||:.:.
 Frog   234 QETLQLVTAHYRTSPFFSV------FVSADSKNSNSNVIQIDQSGLGLPSREFYLNKTENEKVLT 292

  Fly   242 GYLR-------AFGLPEDRIREAIAGVFAF-------------WRDALEI--------------- 271
            |||.       ..|..|:..||.:..:..|             .||..:|
 Frog   293 GYLNFMIQLGVLLGGAENSTREQMQEILDFETTLANITIPQEKRRDEEQIYHKMAAGELKDLVPA 357

  Fly   272 ----PPQCEVFDPYRIKRVFPQSEY--YYNISWSGL-HSTNKLFCDFYYV---------ELDKVC 320
                |....||.|..|....|...|  .|.::.||| :||:|...:.|.:         .||:
 Frog   358 VDWMPFLQTVFYPVAINESEPVVVYAKEYLVAVSGLINSTDKRILNNYMMWNLVRKASSFLDQ-- 420

  Fly   321 ARHRKAVANYLAMKLLYRFDPKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEM 385
               |...|....|:::|. ..|...||::  :|......::.|....:::...|:|..:|:..:|
 Frog   421 ---RFQDAEEKLMEVMYG-TKKTCLPRWK--FCISDTDNNLGFALGAMFVKATFAENSKLQALKM 479

  Fly   386 VRELRKSLRKALEDADWLDAESRARALLKESRIQPRIG---SFQDDALSDRIIREINSLKVIEDR 447
            ::|::.:..:.|....|:|.|:|..|..|...|...||   ...|....|::..:.|   |..|.
 Frog   480 IKEIKAAFEENLSTLTWMDDETRRAAREKAEAIYDMIGYPNFIMDPKELDKVFNDYN---VTSDF 541

  Fly   448 YAETNINLQHLVVQINRFSSRHFQELTND------TKPQKILTGLQVGAGYYTP-DNSINVMAGV 505
            |.|..:...:       ||:|    :|.|      :|.|..:|...|.| ||:| .|.|...||:
 Frog   542 YFENGMRFYN-------FSAR----VTADQLRKAPSKDQWSMTPPTVNA-YYSPTKNEIVFPAGI 594

  Fly   506 VEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMD 570
            ::.|.|....|.:|.||.:|.::||||.|.||.....:|.:|::.......|.:|.:.:.||..:
 Frog   595 LQAPFYTSSSPTALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRPWWKNASVEAFKKQTECITE 659

  Fly   571 YYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPE 635
            .||.|.|.  ...|||:.||.||||||.||:.|..||::    .:...|.|::   :|.|.|:.:
 Frog   660 QYGNYTVN--GEPVNGRQTLGENIADNGGLKAAYRAYKN----WVRKNGAEQL---LPSLGLSND 715

  Fly   636 QLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTC 699
            ||||:||||::||....|...:|| :|.|:..:|||:|.:|||::|...:.|..||.|.|..| |
 Frog   716 QLFFVGFAQVWCSVRTSESSHEGLITDPHSPSRFRVIGSVSNSQEFAEHFRCPPGSPMNPRNK-C 779

  Fly   700 RLW 702
            .:|
 Frog   780 EVW 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	196/715 (27%)
ece1	XP_031762312.1	M13	131..780	CDD:341056	196/715 (27%)