Protein Alignment Nepl12 and mmel1

DIOPT Version :10

• Sequence 1: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_012821551.1
• Gene: mmel1 / 100145721
• XenbaseID: XB-GENE-991673
• Length: 765
• Species: Xenopus tropicalis
• Alignment Length: 773
• Identity: 206/773 - (26%)
• Similarity: 358/773 - (46%)
• Gaps: 140/773 - (18%)

  Fly    12 MLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTN-RSAAEYQLQEYAEFMKSYMNQSVEPCENFY 75
            :||:::..||:.     .||..:.:.:|..::|. .:||...:|.        |:.::|||.:||
 Frog    51 VLLFLMTCAVVA-----LLVLYTSHKESICTTTGCVTAAARIIQN--------MDPTIEPCTDFY 102

  Fly    76 EYACGNYRN--VKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAVAQRFYNAC 138
            :||||.:.|  |.|:   ..||.::.|:....::|.  |.|.:::.:..: ......|:..|.:|
 Frog   103 QYACGGWLNKHVIPE---TSSRYSIFDILRDEMEII--LKGLLEMPDQED-RDAFKKAKILYKSC 161

  Fly   139 LGANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKAS-NFNW-INMSAHLANYGANGLI------- 194
            :..:|.....:.| .|.|:.::|.:|....| |..: ..|| :.....|.||..|..:
 Frog   162 MNESLIEQRDSLP-LLELLTTVGEWPVASTD-WNGTKESNWSLEEKLSLLNYKFNKRVLVDIFVW 224

  Fly   195 ---RETLQ-LRYPFEPYTKLPELGF---------------------------------DHIIVHE 222
               ||:.: :.|..:|...:|...:                                 |..:|.|
 Frog   225 NDDRESSKHIIYIDQPSLGMPSRDYYFNKGNYQRIREAYLQFMITIARMVREDRNLTRDDSLVQE 289

  Fly   223 E-----NISRNTTRAFRLNEER-----------MHGYLRAFGLPEDRIREAIAGVFAFWRDALEI 271
            |     ::..:..||...:|||           :..:.:.|.|.:......|.||.:.....|:.
 Frog   290 EMTRVMDLETDIARATAPSEERNDVTLLYNKMTLLEFQQKFALDDFNWTSFIQGVMSSVNIQLQA 354

  Fly   272 PPQCEVFD-PY--RIKRVFPQSEYYYNISWSGLHSTNKLFCDFYYV---ELDKVCA---RHRKAV 327
            ..:..|:. ||  ::|.:..      |.|.|.|.:        |.|   .:|:|.:   |::.|.
 Frog   355 EEEVVVYGAPYLHQLKNILS------NYSASTLQN--------YVVWRMVIDRVSSLSRRYKDAR 405

  Fly   328 ANYLAMKLLYRFDPKLKAPRYQRNYCSVTLYQSMRFLFNKLYMANNFS-EAKRLEMSEMVRELRK 391
            |:|  .|.||  ...|:..|::.  |...:..:|......:|:...|: |:||: :|:::.::|:
 Frog   406 ASY--RKALY--GTTLEEARWRE--CVSYVNSNMENAVGAMYVKETFAGESKRM-ISDLINKVRE 463

  Fly   392 SLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDAL---SDRIIREINSLKVIEDRYAETNI 453
            :..:.|::..|:|..|:.:|..|...|:.:|| :.|..|   :|::.:|..:|...|.:|.|..:
 Frog   464 AFIETLDELQWMDETSKDKAREKALSIKEQIG-YPDYILEDQNDKLDQETAALNFSEYQYFENIL 527

  Fly   454 NLQHLVVQINRFSSRHFQELTNDTKPQKILTGLQVGAGYYTPD-NSINVMAGVVEPPIYQRHLPI 517
            .:      :|..:.:..::|.........:.|..|...:|:|: |.|...||:::||.:.:|.|.
 Frog   528 EI------LNSGAQKSLKKLREPVDQDAWIIGAAVADAFYSPNRNQIVFPAGILQPPFFNKHQPQ 586

  Fly   518 SLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEIS- 581
            :|.||.:|.::|||:.||||.....||.:|:|....|..|....:|::.|.:..||.| ..|::
 Frog   587 ALNFGGIGMVIGHEITHGFDDNGRNFDKDGNMFDWWSNFSAMHFKDQSRCMVYQYGNY-TWELAG 650

  Fly   582 -RRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQL 645
             :.|:|..||.||||||.|:|||..||    .:.:|..|:|   ..:||||||.:|||||.|||:
 Frog   651 GQNVSGIITLGENIADNGGVRQAYKAY----LKWVERHGKE---PKLPGLDLTYKQLFFLNFAQV 708

  Fly   646 FCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702
            :|..|..|:....: :|||:..::||:|.|.|.|.|...:||..|:.|.|..| ||:|
 Frog   709 WCGSYRPEYARHSIKTDVHSPFKYRVMGSLQNFEAFAEEFNCKKGTKMHPVEK-CRVW 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl12	NP_649924.1	M13	68..700	CDD:341056	191/712 (27%)
mmel1	XP_012821551.1	M13	95..763	CDD:341056	191/712 (27%)