DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9492 and DYNC2H1

DIOPT Version :9

Sequence 1:	NP_001287256.1	Gene:	CG9492 / 41171	FlyBaseID:	FBgn0037726	Length:	4724	Species:	Drosophila melanogaster
Sequence 2:	NP_001073932.1	Gene:	DYNC2H1 / 79659	HGNCID:	2962	Length:	4314	Species:	Homo sapiens

Alignment Length:	4941	Identity:	1182/4941 - (23%)
Similarity:	2061/4941 - (41%)	Gaps:	1029/4941 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 IYIFRVNTSKQ----LPEEGFQKDLYCGVIDAKNI-----GLVTSIERI-VEFVFMQALAFPSLE 220
            ::||   |:.|    |..|.:.:.|.|..::..|.     .::..::|. ....|...:.|
Human    11 LFIF---TTTQNYFGLMSELWDQPLLCNCLEINNFLDDGNQMLLRVQRSDAGISFSNTIEF---- 68

  Fly   221 GDEEDVSCGLIKGQLLPGLRSFCSALRVCEQVCD---HHNVFADGCDMFEK-----IDAVEEV-- 275
            ||.:|..  |:..:|.|            |.:.|   |.|:...  .|.|.     ..||.:|
Human    69 GDTKDKV--LVFFKLRP------------EVITDENLHDNILVS--SMLESPISSLYQAVRQVFA 117

  Fly   276 ----KDMSKNQEFCAQLEERVNNWTKGILKILGESE----QLR-KENDHSG---PQDELEYWKKR 328
                ||...::.|..:|:..::....|:..:|..|:    :|: ||:|..|   |.||.::|.::
Human   118 PMLLKDQEWSRNFDPKLQNLLSELEAGLGIVLRRSDTNLTKLKFKEDDTRGILTPSDEFQFWIEQ 182

  Fly   329 GAQFSQLLAHLQDKEVQFTLHCLFLAGSRIIKQWKETDRKITFCYNEARDNSKFIQAMETCCHSL 393
                    ||..:|::                             ::.|.| .|.:..||.....
Human   183 --------AHRGNKQI-----------------------------SKERAN-YFKELFETIAREF 209

  Fly   394 YLDDPVSMKESILSLLQTVRLI------------YSVSQFYNTSERTSALMVKITNQMIETCKSY 446
            |..|.:|:.| ::.|::|.:.:            |..|:..:..:.......:...:.:.|.
Human   210 YNLDSLSLLE-VVDLVETTQDVVDDVWRQTEHDHYPESRMLHLLDIIGGSFGRFVQKKLGTL--- 270

  Fly   447 ITCRCKETIWSQDRNVIRTKL----SNC----IKLNHIYHETYYTVREQPFLPNQTPFGFSENFV 503
                   .:|.....:::..|    |.|    |..||:..:.:     |.::|:  |:. :|.:
Human   271 -------NLWEDPYYLVKESLKAGISICEQWVIVCNHLTGQVW-----QRYVPH--PWK-NEKY- 319

  Fly   504 FGKFDTFCERLSKIISMFNLIDDYNHLFERRLEGLLLGEALEDASNHFEEAKKE---VTSRKYDY 565
                  |.|.|.|:              .:|||.:|....:.:...:|..|.:|   ..:|.::.
Human   320 ------FPETLDKL--------------GKRLEEVLAIRTIHEKFLYFLPASEEKIICLTRVFEP 364

  Fly   566 LDHRNS-DFN-----------IDFERFIHKTNSLKDTIATLIEKDFDTVWETP-QCIRFLVRFEK 617
            ....|. .:|           ..:|:.|...   :..||..::.....:.::| |.::..:::::
Human   365 FTGLNPVQYNPYTEPLWKAAVSQYEKIIAPA---EQKIAGKLKNYISEIQDSPQQLLQAFLKYKE 426

  Fly   618 VSEKIPLTR--MDEKYTRILRYVEKEVDRILKTFRKQRDD-----------PPLARNFPPIAGRI 669
            :.::..:::  |.|:.|.:.|.|:.     :|.||...::           |...:|...:...|
Human   427 LVKRPTISKELMLERETLLARLVDS-----IKDFRLDFENRCRGIPGDASGPLSGKNLSEVVNSI 486

  Fly   670 HWCRALSLHITELMDAVMEHVVLSSLP-------MAKDLDVRYHNVLGILQEYEDEIVSIWLDQD 727
            .|.|.|.|.:.:.:.  :...:||.||       .||||       |..|:.||.|....| .:|
Human   487 VWVRQLELKVDDTIK--IAEALLSDLPGFRCFHQSAKDL-------LDQLKLYEQEQFDDW-SRD 541

  Fly   728 V------SVADACL--LQPLLSLQGDKLFVNLH--PTIPLLIREAKMLAKLDIELPIVAATLMSR 782
            :      |.:..|:  ...::.|..:...:.:|  ..:.:|:||.:.|:.|...:|
Human   542 IQSGLSDSRSGLCIEASSRIMELDSNDGLLKVHYSDRLVILLREVRQLSALGFVIP--------- 597

  Fly   783 QQYFITIQDSLNCLIKMFLSTVRAVKLEVRPLFLPQLVRLTAMLKPGLHTINWTNQNWTEFYERC 847
                ..||...|...|.                                               |
Human   598 ----AKIQQVANIAQKF-----------------------------------------------C 611

  Fly   848 KQAIESFDVLVARVHDIYSNRILHVLMWMQDVSLQILPADDEIWTVDEFLERSEEACRKAAIELN 912
            ||||     ::.:|...|:                         ::|:.:.:|:
Human   612 KQAI-----ILKQVAHFYN-------------------------SIDQQMIQSQ----------- 635

  Fly   913 RKSQMVSEAVEEVLSLVDRATAAFKEIAGDDVITLFDAATPKGDNSGSGGRKPEDGGGGGGGAAA 977
             :..|:..|:            ||::|.             |...:||||:.
Human   636 -RPMMLQSAL------------AFEQII-------------KNSKAGSGGKS------------- 661

  Fly   978 PSTSGGGGGGQQQDWSILWSCFENPLSLLSTTESLPKGMQDMV-------------CNAVVEMRR 1029
                           .|.|   :||..|....:.|....:.:.             |..||.:..
Human   662 ---------------QITW---DNPKELEGYIQKLQNAAERLATENRKLRKWHTTFCEKVVVLMN 708

  Fly  1030 YYSRKVIDVL---------IKVIRAALDTLRRR-FIADE--------NETVFKKPVFALHAQLQI 1076
                  ||:|         ::.:|..|.|:..: |.|.:        |..::|    ||..|.|:
Human   709 ------IDLLRQQQRWKDGLQELRTGLATVEAQGFQASDMHAWKQHWNHQLYK----ALEHQYQM 763

  Fly  1077 PHVVIKPNLDELQ-DILVTAG-------------------KNITGIAKGVAQWSSGKDPPQVSMT 1121
            ....:..||.|:. |:....|                   |...||.
Human   764 GLEALNENLPEINIDLTYKQGRLQFRPPFEEIRAKYYREMKRFIGIP------------------ 810

  Fly  1122 VQPRVGRNHNESTGGGKSRRRKIYCLASEERPQMPHMLKSFYSAIMDNKEVAKAVNQLASCTKNV 1186
                     |:..|.|:         |.:|         |.:|.::|..  |.....:.|..:::
Human   811 ---------NQFKGVGE---------AGDE---------SIFSIMIDRN--ASGFLTIFSKAEDL 846

  Fly  1187 KPEIQTYIKRWKPYHFLWKNDRTTRQLME---FGLQEFETTLRCLSDLDANLLVEPDMEVFGQCV 1248
            ...:...:.:.|.:..:.:.|  ...|:|   |.:.::|...:.|             ::.|:.|
Human   847 FRRLSAVLHQHKEWIVIGQVD--MEALVEKHLFTVHDWEKNFKAL-------------KIKGKEV 896

  Fly  1249 AVYNEKLKYGLAIEIKSCNHKIGQAMKKKYKKEMDYVYAVINEMDRKLDRPIRDLDDVRMIMETL 1313
                |:|...:.::..:.|              .:.|..||:::.:||      .|.:.:.::..
Human   897 ----ERLPSAVKVDCLNIN--------------CNPVKTVIDDLIQKL------FDLLVLSLKKS 937

  Fly  1314 GKIREQEVDMELRIDPIEEAFNVLTRYEVQVEREQFDLVDNLRATFQNLLAGALQAQVKLLDMQP 1378
            .:....|:|..     :.||..|||.....||    ::.|      .||....||.:..  ::.|
Human   938 IQAHLHEIDTF-----VTEAMEVLTIMPQSVE----EIGD------ANLQYSKLQERKP--EILP 985

  Fly  1379 AFQDD------LRT-------NLDNFKQ--DKISYVTE-YRTAGPMQAGLTPREASDRL-ILFQ- 1425
            .||:.      |||       .:.|.|.  ||...:.| ::.....|..:.......|| |.:|
Human   986 LFQEAEDKNRLLRTVAGGGLETISNLKAKWDKFELMMESHQLMIKDQIEVMKGNVKSRLQIYYQE 1050

  Fly  1426 -NRFEGMWRRLQ------------TYQSGEELFGLPQTDYPELGQIRKEL-------NLLQKLYK 1470
             .:|:..|.:|:            |.....:|....:.::.:|...||:|       .|.:..:.
Human  1051 LEKFKARWDQLKPGDDVIETGQHNTLDKSAKLIKEKKIEFDDLEVTRKKLVDDCHHFRLEEPNFS 1115

  Fly  1471 LYNDVIDRVSSYYDIPWN-----EVDIEEINNE---------------LMEFQNRCRKLPKGLKE 1515
            |.:.:...:.|...| |.     :...:|:.||               ||.:.:|.||:.:
Human  1116 LASSISKDIESCAQI-WAFYEEFQQGFQEMANEDWITFRTKTYLFEEFLMNWHDRLRKVEE---- 1175

  Fly  1516 WPAFHA-----LKKTIDDFNDMCPLLELMANKAMKPRHWQ---RIMDVTRYIFEFDSEGFSLKNI 1572
                |:     |:..:|.:..:.|:|:.:..:.:.|.||.   |::.:.|        |.||:.:
Human  1176 ----HSVMTVKLQSEVDKYKIVIPILKYVRGEHLSPDHWLDLFRLLGLPR--------GTSLEKL 1228

  Fly  1573 LEAPLLKHKE-------DIEDICISAMKEKDIEAKLKQVTNEWSVHE----LQFMSFNNRGELLL 1626
            |...||:..:       |::|:...|..|..|...|::: :.|.|..    :.:....:|...|:
Human  1229 LFGDLLRVADTIVAKAADLKDLNSRAQGEVTIREALREL-DLWGVGAVFTLIDYEDSQSRTMKLI 1292

  Fly  1627 RGDTTAETIGQLEDSLMVLGSLLSNRYNAPFRKQIQQWVYDLSNSNEILERWLLVQNMWVYLEAV 1691
            :  ...:.:.|:.|:..:|.||..:.|...|..::..|...|:..:|.|:....:|..|||||.:
Human  1293 K--DWKDIVNQVGDNRCLLQSLKDSPYYKGFEDKVSIWERKLAELDEYLQNLNHIQRKWVYLEPI 1355

  Fly  1692 FVGGDIAKQLPKEAKRFSKIDKSWQKIMQRAHETPGVVACCVGDDLLKQLLPHLQEQLEICQKSL 1756
            |..|    .||||..||:::|:.::.||....:...|........:...||..| :||:.|||||
Human  1356 FGRG----ALPKEQTRFNRVDEDFRSIMTDIKKDNRVTTLTTHAGIRNSLLTIL-DQLQRCQKSL 1415

  Fly  1757 SGYLERKRMMFPRFFFVSDPALLEILGQASDSHTIQNHLLNIFDNTKSVKFHDVEYNKMMAIISS 1821
            :.:||.||..||||:|:.|..|||||||:::...||:||..:|....||.| |.:...:.|:.|.
Human  1416 NEFLEEKRSAFPRFYFIGDDDLLEILGQSTNPSVIQSHLKKLFAGINSVCF-DEKSKHITAMKSL 1479

  Fly  1822 EGEMIQLDRAIRAEGSVETWLTQLLVTAQASLHSIIRTAYAT------INDPNFTLLSFLEKAPA 1880
            |||::.....:....:|||||..|.:..:.:|..:::....|      ..||:.        .|:
Human  1480 EGEVVPFKNKVPLSNNVETWLNDLALEMKKTLEQLLKECVTTGRSSQGAVDPSL--------FPS 1536

  Fly  1881 QIGLLGIQMVWTRDAEMALMRGRERKVMMETNNKFLEMLNTLIDQTTRNLTKRE----RTNFETL 1941
            ||..|..|:.:|.|.|.|:......::..:..||..:..|  ||.::.:....|    ....:.|
Human  1537 QILCLAEQIKFTEDVENAIKDHSLHQIETQLVNKLEQYTN--IDTSSEDPGNTESGILELKLKAL 1599

  Fly  1942 ITIHVHQRDIFDILCRMNIKSANDFEWLKQCRFYFKEDLDKTWISVTDVTFTYQNEYLGCTDRLV 2006
            |...:|..|:...|.::.:.:..|:.|.||.|||.|.| ....:.:.|..|.|..||.|...:||
Human  1600 ILDIIHNIDVVKQLNQIQVHTTEDWAWKKQLRFYMKSD-HTCCVQMVDSEFQYTYEYQGNASKLV 1663

  Fly  2007 ITPLTDRCYITLAQALTLSMGGAPCGPAGTGKTETVKDMGKTLAKYVVVFNCSDQMDYRGLGRIY 2071
            .|||||:||:||.||:.:.:||.|.|||||||||:||.:|..|.:.|:||||.:.:|.:.:|||:
Human  1664 YTPLTDKCYLTLTQAMKMGLGGNPYGPAGTGKTESVKALGGLLGRQVLVFNCDEGIDVKSMGRIF 1728

  Fly  2072 KGLAQSGSWGCFDEFNRIELPVLSVAAQQVAVVLTAKKEKRKTFLFTDGDTIEMNPEFGIFITMN 2136
            .||.:.|:|||||||||:|..|||..:.|:..:..|.|..| |.....|..:|:|...|||||||
Human  1729 VGLVKCGAWGCFDEFNRLEESVLSAVSMQIQTIQDALKNHR-TVCELLGKEVEVNSNSGIFITMN 1792

  Fly  2137 P---GYAGRKELPENLKIQFRTVAMMVPDRQIIIRVKLASCGFLENITLARKFYTLYKLCEEQLT 2198
            |   ||.||::||:|||..||.|||..||.::|..|.|.|.||.:...|:||...::.|..|.||
Human  1793 PAGKGYGGRQKLPDNLKQLFRPVAMSHPDNELIAEVILYSEGFKDAKVLSRKLVAIFNLSRELLT 1857

  Fly  2199 KQVHYDFGLRNILSVLRTLGAAKRRNSKD------TESTIVMRVLRDMNLSKLIDDDEPLFMSLV 2257
            .|.|||:|||.:.:|||..|...|:.:|.      .||.||::.||...:||....|...|.:|:
Human  1858 PQQHYDWGLRALKTVLRGSGNLLRQLNKSGTTQNANESHIVVQALRLNTMSKFTFTDCTRFDALI 1922

  Fly  2258 SDLFPNQTLEKTNYPELEAAILQQTDEASLVYHPPWVLKLIQLYETQHVRHGIMTLGPSGAGKTT 2322
            .|:||...|::..|.||.||:.|..:||:....|..:.|.::|||....|.|::.:|||||||:|
Human  1923 KDVFPGIELKEVEYDELSAALKQVFEEANYEIIPNQIKKALELYEQLCQRMGVVIVGPSGAGKST 1987

  Fly  2323 CIHTLMKAMTQMGDNHREMRMNPKAITAAQMFGRLDVATNDWTDGIFSALWRKTLKLKAGEHVWL 2387
            ....|..|:.:.|...::..|||||:...|:.|.:|:.|.:|:||:.:...|:.::.......|:
Human  1988 LWRMLRAALCKTGKVVKQYTMNPKAMPRYQLLGHIDMDTREWSDGVLTNSARQVVREPQDVSSWI 2052

  Fly  2388 VLDGPVDSIWIENLNSVLDDNKTLTLANGDRLTMAPTVKIIFEPHNIDNASPATVSRNGMVYMSS 2452
            :.||.:|..|||:||||||||:.||:.:|:|:...|.|..:||.|::..|||||:||.||:::|.
Human  2053 ICDGDIDPEWIESLNSVLDDNRLLTMPSGERIQFGPNVNFVFETHDLSCASPATISRMGMIFLSD 2117

  Fly  2453 SGLDSRPIVQAWLKNRAPGEKSTFSDLFDQTFVEVYNWGVQMVKLQMPVLQCNIVQQMLFILEGL 2517
            ...|...::::||:|:....::...:.....|.:...|   ::|....|::.::|..   ::.||
Human  2118 EETDLNSLIKSWLRNQPAEYRNNLENWIGDYFEKALQW---VLKQNDYVVETSLVGT---VMNGL 2176

  Fly  2518 IPVKKEDEQAVSMSSKESHDANKRLEHQKHVEEARRQSIGSQIVEDLPPETSIEEKEDTCTPEHL 2582
                                        .|:...|.
Human  2177 ----------------------------SHLHGCRD----------------------------- 2184

  Fly  2583 HRLYIFALAWGLGGYLSTSDRQRMNLFVKESF-------PQLDYPKGSAHENTIFDFFVSPAGVW 2640
            |..:|..|..||||.|:...|..   |.||.|       |....|..:.:::|
Human  2185 HDEFIINLIRGLGGNLNMKSRLE---FTKEVFHWARESPPDFHKPMDTYYDST------------ 2234

  Fly  2641 QSWKTLVTPYMY--PELSTPDYLS--ILVPIV---DNVR-IDYLIGTIANQ-ERAVMVIGEQGTG 2696
               :..:..|:.  ||..|.|..|  :.:|::   |..| :||....:::. ::..:::|.:|.|
Human  2235 ---RGRLATYVLKKPEDLTADDFSNGLTLPVIQTPDMQRGLDYFKPWLSSDTKQPFILVGPEGCG 2296

  Fly  2697 KTVIMKNFMKKMNVESYMGRSFNFSS------ATSPYQFQRTIES--YVEKRVGVTFGPPGGRKL 2753
            |.::::....::       ||...::      .||.:..|:..::  .:....|..:.|....:|
Human  2297 KGMLLRYAFSQL-------RSTQIATVHCSAQTTSRHLLQKLSQTCMVISTNTGRVYRPKDCERL 2354

  Fly  2754 IVFIDDINLPEINEWGDQITNEIVRQSMDMKGFY--SLEKPGDFTTIVDVQYVAAMGLPGG-GRN 2815
            ::::.|||||::::||.......::|.:..:|||  :||..|    :.::|.||:|...|. ||:
Human  2355 VLYLKDINLPKLDKWGTSTLVAFLQQVLTYQGFYDENLEWVG----LENIQIVASMSAGGRLGRH 2415

  Fly  2816 DIPSRLKRQFCVFNCNIPDNDSIDKIFRVIGEG--HYNAKR----GFVPEIRSLVKKLIVVTRHL 2874
            .:.:|......:.:.:.|:.:.:..|:....|.  |.|.|.    |...:|..|...::.|
Human  2416 KLTTRFTSIVRLCSIDYPEREQLQTIYGAYLEPVLHKNLKNHSIWGSSSKIYLLAGSMVQV---- 2476

  Fly  2875 WQRTREKLLPTPAKF------HYVFSLRDLSRIWQGMVGTLSTVITSES------VLMALWKHEC 2927
            :::.|       |||      ||.|:...|:   |.::|.....:...|      .::.:..:|.
Human  2477 YEQVR-------AKFTVDDYSHYFFTPCILT---QWVLGLFRYDLEGGSSNHPLDYVLEIVAYEA 2531

  Fly  2928 TRVFADRFTTFQDKEWFGSELACLVREELGDSHSQMI--LPNPVFVDF-------MRDAP-EPTG 2982
            .|:|.|:....::...|...|..:.:   ||..|.::  :.:..:|.:       .|.|| :|..
Human  2532 RRLFRDKIVGAKELHLFDIILTSVFQ---GDWGSDILDNMSDSFYVTWGARHNSGARAAPGQPLP 2593

  Fly  2983 EEGE------DTDMELPKVYEPVHSHEVLRERLVMFLAQFNEMVRGSGMDLVFFPDAMLHLVKIS 3041
            ..|:      .||::           :|:::.|:.: .:.|:     .:|::.|.:.:.::.:|.
Human  2594 PHGKPLGKLNSTDLK-----------DVIKKGLIHY-GRDNQ-----NLDILLFHEVLEYMSRID 2641

  Fly  3042 RIIRHPRGSVMLVGVGGSGKQSLTKLASFIAGYKTFQIALTRSYNVANFLEDLKLLYRTCGVQGK 3106
            |::..|.||::|.|..|.|::::|.|.|.:.|...|...::|.|.:..|..|||.:.:..|::.:
Human  2642 RVLSFPGGSLLLAGRSGVGRRTITSLVSHMHGAVLFSPKISRGYELKQFKNDLKHVLQLAGIEAQ 2706

  Fly  3107 GTTFLFTDMDIKEEGFLEYLNNILSSGVISNLFSRDEQAEIVQELTPVMKRENQRKTATPESVMD 3171
            ....|..|.......|||.:|::||||.:..|::.:|...:   |.|:..:.:|.....|  |.:
Human  2707 QVVLLLEDYQFVHPTFLEMINSLLSSGEVPGLYTLEELEPL---LLPLKDQASQDGFFGP--VFN 2766

  Fly  3172 FFLARTCTNLHVAFCFSPVGETFRSRVQRFPALVSGCTIDWLHPWPKDALVSVARHFLSHF---- 3232
            :|..|...|||:..........|....:..|||...|.:.|:..|...::..:.....|..
Human  2767 YFTYRIQQNLHIVLIMDSANSNFMINCESNPALHKKCQVLWMEGWSNSSMKKIPEMLFSETGGGE 2831

  Fly  3233 EIECTPAVKEELVNALGSIQDIVAETSQEYFQRFR------RATHVTPKSYLNFIAGYKNIYQMK 3291
            :.......:|:..|::          ..::.:.|.      :|...||..|:.|:..|..|...|
Human  2832 KYNDKKRKEEKKKNSV----------DPDFLKSFLLIHESCKAYGATPSRYMTFLHVYSAISSSK 2886

  Fly  3292 QQELRDGVEKMDTGLEKLKEASASVEILKKDLVVMEEELVEASKNAESVLVEVTERAMQAEIVKN 3356
            ::||......:..|:.||.||.|.|:.|.:........|......|::.|..:|.....|...|.
Human  2887 KKELLKRQSHLQAGVSKLNEAKALVDELNRKAGEQSVLLKTKQDEADAALQMITVSMQDASEQKT 2951

  Fly  3357 QVLIVKDKAEALVACIAHEKALAEEKLEAAKPALEEAENALNTIKPAHIATVRKLGRPPHLIMRI 3421
            ::..:|.:....|..|...|...:::|:..:|.:.||:.|:..|||..::.:|.|..||.:|..|
Human  2952 ELERLKHRIAEEVVKIEERKNKIDDELKEVQPLVNEAKLAVGNIKPESLSEIRSLRMPPDVIRDI 3016

  Fly  3422 MDCVLILFKRKLHPCIPDAGTPCPKPSWQESLKMMAS-------ATFLLQLQNYPKDTINDEMID 3479
            ::.||.|..      |.|.       ||......:|.       |||  ..:|..|: |.:.:.:
Human  3017 LEGVLRLMG------IFDT-------SWVSMKSFLAKRGVREDIATF--DARNISKE-IRESVEE 3065

  Fly  3480 LLQPYFRMEDYNMDMARRVCGDVAGLLSWTKAMSFFHSVNKEVLPLKANLTMQEARLKLAMDDLA 3544
            ||  :.....::...|:|.....|.|.:|.||...:..|.:.:.||:......|:.||...|...
Human  3066 LL--FKNKGSFDPKNAKRASTAAAPLAAWVKANIQYSHVLERIHPLETEQAGLESNLKKTEDRKR 3128

  Fly  3545 GAEEQLREREEALQAVKDQYDKAVGEKQRLTDAANVCLRKMTAATALINGLSDEKHRWTNQSKEF 3609
            ..||.|....:.:..:|:::.....|..:|....:.....:.||..|||.|..|..||..|..|.
Human  3129 KLEELLNSVGQKVSELKEKFQSRTSEAAKLEAEVSKAQETIKAAEVLINQLDREHKRWNAQVVEI 3193

  Fly  3610 KIQLGKLVGDVLLATGFLSYCGPYNQEFRANLIKTWMGILKQKNIPFTTGLNIINMLVDSSTVSE 3674
            ..:|..|.....||..|::|.....:..|...::.|..         :.||...::.....|.||
Human  3194 TEELATLPKRAQLAAAFITYLSAAPESLRKTCLEEWTK---------SAGLEKFDLRRFLCTESE 3249

  Fly  3675 ---WTLQGLPNDELSVQNAL-----IATKSSS--YPLLVDPQTQGKIWIKCKEDRNELQITSLNH 3729
               |..:|||:|:||::|||     |..||.|  .|.|:||.:|...|:|.....:.|::.:...
Human  3250 QLIWKSEGLPSDDLSIENALVILQIIGLKSWSRVCPFLIDPSSQATEWLKTHLKDSRLEVINQQD 3314

  Fly  3730 KYFRTHLEDSLSLGRPLLIEDVGIDLDPVIDNVLEKNFIKSGSIEKVLVGDKECDVMPGFMLYIT 3794
            ..|.|.||.::..|:.|:|:::. .::||:..:|.::.:..|....|.:|||..|....|.|:::
Human  3315 SNFITALELAVRFGKTLIIQEMD-GVEPVLYPLLRRDLVAQGPRYVVQIGDKIIDYNEEFRLFLS 3378

  Fly  3795 TKLPNPAFSPEVSAKTSIIDFTVTMRGLEDQLLGRVILMEKSDLEAERVALFETVMQNQRNMKEL 3859
            |:.|||...|:.::..:.::||.|..||..|||...|..||.|||.::..|.:.....:..:.:|
Human  3379 TRNPNPFIPPDAASIVTEVNFTTTRSGLRGQLLALTIQHEKPDLEEQKTKLLQQEEDKKIQLAKL 3443

  Fly  3860 EANLLLRLSSSQGSLVDDEALIEVLRVTKTTAEEVNQKLKISEVTERKIMKAREEFRAVAKRGSI 3924
            |.:||..|::|||::::::.|||.|..||.::..:.:.||.|...:..:.:.|:.:..:|:..|.
Human  3444 EESLLETLATSQGNILENKDLIESLNQTKASSALIQESLKESYKLQISLDQERDAYLPLAESASK 3508

  Fly  3925 LYFLIVEMSNVNAMYQNSLKQFLVIFNHSITKSTKSSVTEERINIILRYLTYEVYKFTNRSLYER 3989
            :||:|.::|.:|.||:.||..||.:|..::.....|..||:||..::..|.:.||::..|.|::.
Human  3509 MYFIISDLSKINNMYRFSLAAFLRLFQRALQNKQDSENTEQRIQSLISSLQHMVYEYICRCLFKA 3573

  Fly  3990 HKQLFTLMLAIKIDYHNGNISHEEFLTFI---------KGGASLDLNAVTPKPFRWI-LDITW-L 4043
            .:.:|.|.....:  |.......|:.||.         |..:...:....|.   || .:.:| :
Human  3574 DQLMFALHFVRGM--HPELFQENEWDTFTGVVVGDMLRKADSQQKIRDQLPS---WIDQERSWAV 3633

  Fly  4044 NLVEISKLETFSTVLQVIELNEKD---WRCWYE---CEKPENEEIPCGYNAILDGFRKLLLIRSW 4102
            ..::|:....:.|      |..:|   ||.:|.   ||    :|.|......:..|:::|::::.
Human  3634 ATLKIALPSLYQT------LCFEDAALWRTYYNNSMCE----QEFPSILAKKVSLFQQILVVQAL 3688

  Fly  4103 CPDRTISQAKKYIEESLGPEYSEMQILDLEEMWLESEPRTPFVCLLSIGSDPTTQIGAL--AKQK 4165
            .|||..|....:..::||.:......|:|:.::.|:....|.:.::|.|:||:.::..|  |::.
Human  3689 RPDRLQSAMALFACKTLGLKEVSPLPLNLKRLYKETLEIEPILIIISPGADPSQELQELANAERS 3753

  Fly  4166 SIVLKSVSMGQGQEYHARKMIIESMAIGGWVLLQNVHLS---LPFCSEIIDMLVESEHIDDSFRM 4227
            ......|:|||||...|.:|:.|....|.|:.|:|:||.   ||...:.::.|...    |:||:
Human  3754 GECYHQVAMGQGQADLAIQMLKECARNGDWLCLKNLHLVVSWLPVLEKELNTLQPK----DTFRL 3814

  Fly  4228 WVTTEPHNEFPIGLLQMALKFTNEPPQGIRASLKRSYQSFTQDFLDYTSATQWPPLLYTVAFLHT 4292
            |:|.|.|..|...|||.:||.|.|.|.|::.:|.|:|:|:|.:.:.....|.....|:::|:.|.
Human  3815 WLTAEVHPNFTPILLQSSLKITYESPPGLKKNLMRTYESWTPEQISKKDNTHRAHALFSLAWFHA 3879

  Fly  4293 IVQERRKFGPLGWNIPYEFNQADFAASVQFIQNHLDEM-DPKKGVSWQTLVYMIGEVQYGGRVTD 4356
            ..||||.:.|.||...|||:.:|..|.    .|.:|.: |..|.|.|:.:..::....||||:.:
Human  3880 ACQERRNYIPQGWTKFYEFSLSDLRAG----YNIIDRLFDGAKDVQWEFVHGLLENAIYGGRIDN 3940

  Fly  4357 DFDKRLLTTFTSVWFCEPLLSNSFEFYKGYKVPGTKSLQ---GFIDY---INSLPAYDTPEVFGL 4415
            .||.|:|.::...:|...::....:..|....|.:.||.   ..:||   |..:|..|.|..|||
Human  3941 YFDLRVLQSYLKQFFNSSVIDVFNQRNKKSIFPYSVSLPQSCSILDYRAVIEKIPEDDKPSFFGL 4005

  Fly  4416 HSNAD------ITYQINSAKGILDTILSVQPKEGGGGGGETRESIVYQLAD--DMLRKLPAQYNA 4472
            .:|..      |:.|:.|...||...::       .|....||....:|:.  ::.:||....|.
Human  4006 PANIARSSQRMISSQVISQLRILGRSIT-------AGSKFDREIWSNELSPVLNLWKKLNQNSNL 4063

  Fly  4473 --YEVRENLTRMGILLPMNIFLRQEIDRMQRVIKRVHTCLCDLKLAIDGTIVMSPALKESLDAMY 4535
              .:|.....|.|  .|:..|:..|.....|:::.||..|..|...|.||.::|..:::...|:.
Human  4064 IHQKVPPPNDRQG--SPILSFIILEQFNAIRLVQSVHQSLAALSKVIRGTTLLSSEVQKLASALL 4126

  Fly  4536 DARIPETWMKISWESTTLGFWYTE-LLERNGQFRTWISTDRPKVFW-----MTGFFNPQGFLTAM 4594
            :.:.|..|.. .||.......|.. |:.|....:.|:.....:...     ::..|:|..||.|:
Human  4127 NQKCPLAWQS-KWEGPEDPLQYLRGLVARALAIQNWVDKAEKQALLSETLDLSELFHPDTFLNAL 4190

  Fly  4595 RQEVTRAHKGWALDSVVLQNQITRYNKEDITEYPTEGVYVHGLFLEGASLDRRSGKLIESKM--K 4657
            |||..|| .|.::||:    :.....|..:.|...: :.:.||.|||.|.|  ..:|.|:::  .
Human  4191 RQETARA-VGRSVDSL----KFVASWKGRLQEAKLQ-IKISGLLLEGCSFD--GNQLSENQLDSP 4247

  Fly  4658 VLYEQMPVIYIYAINTTAGK-DPKLYEC---PIYRKPQRTDLKYVGSIDFETEFNPKHWTLRGVA 4718
            .:...:|....:......|. .|.  ||   |:|...:|.  :.|.:||.....|...|...|.|
Human  4248 SVSSVLPCFMGWIPQDACGPYSPD--ECISLPVYTSAERD--RVVTNIDVPCGGNQDQWIQCGAA 4308

  Fly  4719 L 4719
            |
Human  4309 L 4309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9492	NP_001287256.1	DHC_N1	283..843	CDD:285571	106/633 (17%)
		DYN1	1178..4372	CDD:227570	897/3403 (26%)
		DHC_N2	1458..1861	CDD:285579	119/448 (27%)
		P-loop_NTPase	1994..2222	CDD:304359	114/230 (50%)
		P-loop_NTPase	2309..2444	CDD:304359	54/134 (40%)
		P-loop_NTPase	2662..2926	CDD:304359	61/299 (20%)
		P-loop_NTPase	3025..3287	CDD:304359	62/271 (23%)
		MT	3300..3646	CDD:289543	86/352 (24%)
		AAA_9	3674..3890	CDD:289547	75/225 (33%)
		Dynein_heavy	4031..4713	CDD:281078	190/723 (26%)
DYNC2H1	NP_001073932.1	Stem. /evidence=ECO:0000250	1..1650		401/2065 (19%)
		DHC_N1	162..639	CDD:285571	109/674 (16%)
		DHC_N2	1120..1519	CDD:285579	114/424 (27%)
		P-loop_NTPase	1651..1881	CDD:304359	114/230 (50%)
		AAA 1. /evidence=ECO:0000250	1651..1875		112/224 (50%)
		P-loop_NTPase	<1937..>1988	CDD:304359	21/50 (42%)
		AAA 2. /evidence=ECO:0000250	1938..2161		79/225 (35%)
		AAA_5	1974..2110	CDD:285029	55/135 (41%)
		AAA 3. /evidence=ECO:0000250	2251..2505		60/278 (22%)
		P-loop_NTPase	2285..2494	CDD:304359	50/230 (22%)
		AAA 4. /evidence=ECO:0000250	2617..2863		57/266 (21%)
		P-loop_NTPase	2618..>2829	CDD:304359	54/221 (24%)
		Stalk. /evidence=ECO:0000250	2881..3169		72/305 (24%)
		MT	2897..3229	CDD:289543	86/349 (25%)
		AAA_9	3253..3474	CDD:289547	74/221 (33%)
		Dynein_heavy	3622..4303	CDD:281078	190/723 (26%)
		AAA 6. /evidence=ECO:0000250	3697..3912		69/222 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810