DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9492 and DYNC1H1

DIOPT Version :9

Sequence 1:	NP_001287256.1	Gene:	CG9492 / 41171	FlyBaseID:	FBgn0037726	Length:	4724	Species:	Drosophila melanogaster
Sequence 2:	NP_001367.2	Gene:	DYNC1H1 / 1778	HGNCID:	2961	Length:	4646	Species:	Homo sapiens

Alignment Length:	4874	Identity:	1214/4874 - (24%)
Similarity:	2154/4874 - (44%)	Gaps:	882/4874 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 VEEVKDMSKNQEFCAQLEERVNNWTKGILKILGESEQLRKENDHSGPQDELEYWKKRGAQFSQLL 336
            |.:..|..::..|..||:..||.|.:.|.|:    .:|.::........|:.:|    ....:.|
Human   229 VTDFGDKVEDPTFLNQLQSGVNRWIREIQKV----TKLDRDPASGTALQEISFW----LNLERAL 285

  Fly   337 AHLQDK----EVQFTLHCLFLAGSRIIKQWKETDRKITFCYNEARDNSKFIQAMETC--CHSLYL 395
            ..:|:|    ||..||.        |:|..|.....::|     ..::...||:||.  .:.|..
Human   286 YRIQEKRESPEVLLTLD--------ILKHGKRFHATVSF-----DTDTGLKQALETVNDYNPLMK 337

  Fly   396 DDPVS----------MKESILSLLQTVRLI----YSVSQFYN----TSERTSALMVKI--TNQMI 440
            |.|::          ::::::::...:|.|    |.:.:...    .|...|:.::|:  |.:::
Human   338 DFPLNDLLSATELDKIRQALVAIFTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLM 402

  Fly   441 ETC-----KSYITCRCKETIWSQD--------RNVIRTKLSNCIK----LNHIY----------- 477
            ...     |..:.|......|..:        |::::.|....:|    :|..:
Human   403 HVAYEEFEKVMVACFEVFQTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMR 467

  Fly   478 -----HE--------------TYYTVREQPFLPNQTPFGFSENFVFGKFDTFCERLSKIISMFNL 523
                 ||              |....:.|..:|.......:| .:|...|.            |.
Human   468 KFRRQHEQLRAVIVRVLRPQVTAVAQQNQGEVPEPQDMKVAE-VLFDAADA------------NA 519

  Fly   524 IDDYNHLFE--RRLEGLLLG----EALEDASNHFEE----AKKEVTSRKYDYL---DHRNSDFNI 575
            |::.|..:|  :.::||.:.    ||.|.|...::|    .:..:|:|..|.|   .:.|..|.|
Human   520 IEEVNLAYENVKEVDGLDVSKEGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRI 584

  Fly   576 DFERFIHKTNSLKDTIATLIEKDFDTVWETPQCIRFLVRFEKVSEKIPLTRMDEKYTRILRYVEK 640
             |.|                   |:.::..|. ||..:|              |..|::::.|:.
Human   585 -FSR-------------------FNALFVRPH-IRGAIR--------------EYQTQLIQRVKD 614

  Fly   641 EVDRILKTFRKQRDDPPL-----ARNFPPIAGRIHWCRALSLHITELMDAVMEHVVLSSLPMAKD 700
            :::.:...|:.|......     .|:.||::|.|.|.:.:...:|..|.
Human   615 DIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTAYMK---------------- 663

  Fly   701 LDVRYHNVLGILQEYEDEIVSIWLDQDVSVADACLLQPLLSLQGDKLFVNLHPTIPLLIREAKML 765
               |..:|||  :.:|:.:....|.||                ||...:.|: |..:....|:.:
Human   664 ---RVEDVLG--KGWENHVEGQKLKQD----------------GDSFRMKLN-TQEIFDDWARKV 706

  Fly   766 AKLDIELPIVAATLMSRQQYFITIQDSLNCLIKMFLSTVRAVKLEVRPLFLPQLVRLTAMLKPGL 830
            .:.::.:          .....||:.:     ::...|...:||:|.  |||:::.|:..::
Human   707 QQRNLGV----------SGRIFTIEST-----RVRGRTGNVLKLKVN--FLPEIITLSKEVR--- 751

  Fly   831 HTINWTNQNWTEFYERCKQAIESFDVLVARVHDIYSNRILHVLMWMQDVSLQILPADDEIWTVDE 895
                  |..|..|  |...||      |.:.|.  :|::....:                 ::.|
Human   752 ------NLKWLGF--RVPLAI------VNKAHQ--ANQLYPFAI-----------------SLIE 783

  Fly   896 FLERSEEACRKAAIELNRKSQMVSEAVEEVLSLVDRATAAFKEIAGDDVITLFDAATPKGDNSGS 960
            .:...|..|.|.. |.|..|.:|:...:||.:|:....|
Human   784 SVRTYERTCEKVE-ERNTISLLVAGLKKEVQALIAEGIA-------------------------- 821

  Fly   961 GGRKPEDGGGGGGGAAAPSTSGGGGGGQQQDWSILWSCFE-NPL--SLLSTTESLPKGMQDMVC- 1021
                                             ::|..:: :|.  .|..|..:..:.:.|::.
Human   822 ---------------------------------LVWESYKLDPYVQRLAETVFNFQEKVDDLLII 853

  Fly  1022 --NAVVEMRR----YYSRKVIDVLIKVIRAALDTLRRRFIADENETVFKKPVFALHAQLQIPHVV 1080
              ...:|:|.    .|..|....::..::.|:|.|.                  ||:...:|..|
Human   854 EEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLN------------------LHSYSNLPIWV 900

  Fly  1081 IKPNLDELQDIL---VTAG-----KNITGIAKGVAQWSSGKDPPQVS-----------------M 1120
            .|.:: |::.||   :.||     :.:.|.|:..|:.....|.||||                 :
Human   901 NKLDM-EIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVHELRI 964

  Fly  1121 TVQ-----------------------------PRVGRN------HNESTGGGKSRRRKIYCLASE 1150
            |.|                             ||:...      |.|.|     ...|.|..|..
Human   965 TNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELT-----EEEKFYRNALT 1024

  Fly  1151 ERPQMPHMLKSFYSAIMDNKEVAKAVNQLASCTKNVKPEIQTYIKRWKPYHFLW--KNDRTTRQL 1213
            ..|..|..|:..|||:|                 .:..|::.|:|.|..|..||  :.:....:|
Human  1025 RMPDGPVALEESYSAVM-----------------GIVSEVEQYVKVWLQYQCLWDMQAENIYNRL 1072

  Fly  1214 MEFGLQEFETTLRCLSDLDANLLVEPDMEVFGQCVAVYNE-----KLKY-GLAIEIKSCNHKIGQ 1272
            .| .|.:::..|..:.............:.||..|..|.:     .||| ....|:.|   |.||
Human  1073 GE-DLNKWQALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLS---KFGQ 1133

  Fly  1273 AMKKKYKKEMDYVYAVINEMDRKLDRPIRDL----DDVRMI--METL-GKIREQEVDMEL----- 1325
            .:    ...|...::.|::..::|::...|.    |.|..|  :::| .||::.|..:||
Human  1134 ML----GSNMTEFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQ 1194

  Fly  1326 RIDPIEEAFNVLTRYEVQVEREQFDL------VDNLR---ATFQNLLA---GALQAQVKLLDMQP 1378
            |:                :|:::|..      :||:.   ..|.:::.   .|:|.||..|.|:.
Human  1195 RL----------------LEKQRFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKI 1243

  Fly  1379 AFQD---DLRTNLDNFKQDKISYVTEYRTAGPMQAGLTPREASDRLILFQNRFEGMWRRLQTYQS 1440
            ..:|   :.||.         ..:|::....|:...|.|.||...|.:::.:|..:....:....
Human  1244 VQEDRAVESRTT---------DLLTDWEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAK 1299

  Fly  1441 GEELFGLPQTDYPELGQIR-----KELNLLQKLYKLYNDVIDRVSSYYDIPWNEVDIEEINNELM 1500
            .:|...|..|......:.|     :||..|:.::...:.|.:::....:.||..|...::...|.
Human  1300 AKEALELTDTGLLSGSEERVQVALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLD 1364

  Fly  1501 EFQNRCRKLPKGLKEWPAFHALKKTIDDFNDMCPLLELMANKAMKPRHWQRIMDVTRYIFEFDSE 1565
            ...|:.:..|..|:::.::..:::.:..:..:..|:..:.::|:|.|||:::|  .|....:...
Human  1365 ALLNQLKSFPARLRQYASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLM--KRLHVNWVVS 1427

  Fly  1566 GFSLKNILEAPLLKHKEDIEDICISAMKEKDIEAKLKQVTNEWSVHELQFMSFNNRGELLLRGDT 1630
            ..:|..|.:..|.|::..::|:.:.|..|..:|..|||:...|:.:||..:::.|:..|:...|
Human  1428 ELTLGQIWDVDLQKNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWD- 1491

  Fly  1631 TAETIGQLEDSLMVLGSLLSNRYNAPFRKQIQQWVYDLSNSNEILERWLLVQNMWVYLEAVFVG- 1694
              :...::::.:..:.::..:.|...|.:....|...|:....:.:.|:.||..|||||.:|.|
Human  1492 --DLFNKVKEHINSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGS 1554

  Fly  1695 GDIAKQLPKEAKRFSKIDKSWQKIMQRAHETPGVVACCVGDDLL-----KQLLPHLQEQLEICQK 1754
            .||...||.|.:||..|...:..:|::..::|.|:      |:|     ::.|..|.:.|...||
Human  1555 ADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVM------DVLNIQGVQRSLERLADLLGKIQK 1613

  Fly  1755 SLSGYLERKRMMFPRFFFVSDPALLEILGQASDSHTIQNHLLNIFDNTKSVKFHDVEYNKMMAII 1819
            :|..||||:|..||||:||.|..||||:|.:.:...:|.|...:|....|:..:: :.:.::.|.
Human  1614 ALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNE-DNSVVLGIS 1677

  Fly  1820 SSEGE--MIQLDRAIRAEGSVETWLTQLLVTAQASLHSIIRTAY--------ATINDPNFTLLSF 1874
            |.|||  |.:...:|.....:..|||.:....:.:|..::..:.        ||..||| |.:::
Human  1678 SREGEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPN-TYITW 1741

  Fly  1875 LEKAPAQIGLLGIQMVWTRDAEMAL--MRGRERKVMMETNNKFLEM-LNTLIDQTTRNLTKRERT 1936
            ::|..||:.:|..|:.|:.:.|.||  |.|......:.:....:|: ||.|.|..........|.
Human  1742 IDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQPPLRRR 1806

  Fly  1937 NFETLITIHVHQRDIFDILCRMNIKSANDFEWLKQCRFYF----KEDLDKTWISVTDVTFTYQNE 1997
            ..|.|||..|||||:...|.:..|.:|..||||.|.||||    .:.|.:..|.:.:..|.|..|
Human  1807 KLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQMANAKFNYGFE 1871

  Fly  1998 YLGCTDRLVITPLTDRCYITLAQALTLSMGGAPCGPAGTGKTETVKDMGKTLAKYVVVFNCSDQM 2062
            |||..|:||.||||||||:|:.|||...:||:|.|||||||||:||.:|..|.::|:||||.:..
Human  1872 YLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALGHQLGRFVLVFNCDETF 1936

  Fly  2063 DYRGLGRIYKGLAQSGSWGCFDEFNRIELPVLSVAAQQVAVVLTAKKE-------KRKTFLFTD- 2119
            |::.:|||:.||.|.|:|||||||||:|..:||..:|||..:..|.:|       |....:..:
Human  1937 DFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQEALREHSNPNYDKTSAPITCEL 2001

  Fly  2120 -GDTIEMNPEFGIFITMNPGYAGRKELPENLKIQFRTVAMMVPDRQIIIRVKLASCGFLENITLA 2183
             ...::::|:..||||||||||||..||:|||..||::||..||||:|.:|.|.|.||.....||
Human  2002 LNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTKPDRQLIAQVMLYSQGFRTAEVLA 2066

  Fly  2184 RKFYTLYKLCEEQLTKQVHYDFGLRNILSVLRTLGAAKR------RNSKD--------------- 2227
            .|....:|||:|||:.|.|||||||.:.|||.:.|..||      :..|:
Human  2067 NKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSAGNVKRERIQKIKREKEERGEAVDEGEIAENL 2131

  Fly  2228 TESTIVMRVLRDMNLSKLIDDDEPLFMSLVSDLFPNQTLEKTNYPELEAAILQQTDEASLVYHP- 2291
            .|..|:::.:.:..:.||:.:|.||..||:||:||.....:.....|...:.:...|..|.|..
Human  2132 PEQEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDG 2196

  Fly  2292 -----PWVLKLIQLYETQHVRHGIMTLGPSGAGKTTCIHTLMKAMTQM----GDNHREMRMNPKA 2347
                 .||.|::|||:...:.||:|.:||||:||:.....|:||:.::    |..|   .::|||
Human  2197 EEVGGMWVEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALERLEGVEGVAH---IIDPKA 2258

  Fly  2348 ITAAQMFGRLDVATNDWTDGIFSALWRKTLKLKAGE---HVWLVLDGPVDSIWIENLNSVLDDNK 2409
            |:...::|.||..|.:||||:|:.:.||.:....||   ..|:|.||.||..|:|||||||||||
Human  2259 ISKDHLYGTLDPNTREWTDGLFTHVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNK 2323

  Fly  2410 TLTLANGDRLTMAPTVKIIFEPHNIDNASPATVSRNGMVYMSSSGLDSRPIVQAWL--------- 2465
            .|||.||:||::.|.|:|:||..::..|:.|||||.|||:.|...|.:..|...:|
Human  2324 LLTLPNGERLSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLD 2388

  Fly  2466 ------KNRAPGEKSTFSDLFDQTFVEVYNWGVQMVKLQMPVLQCN----IVQQMLFILEGLIPV 2520
                  :.|..|::.                  :..:...|:||..    .:.|..|...||:
Human  2389 EGEDEAQRRRKGKED------------------EGEEAASPMLQIQRDAATIMQPYFTSNGLV-- 2433

  Fly  2521 KKEDEQAVSMSSKESHDANKRLEHQKHVEE----ARRQSIGS----------QIVE------DLP 2565
                              .|.|||...:|.    .|.:.:||          .:.:      |.|
Human  2434 ------------------TKALEHAFQLEHIMDLTRLRCLGSLFSMLHQACRNVAQYNANHPDFP 2480

  Fly  2566 PETSIEEKEDTCTPEHLHRLYIFALAWGLGGYLSTSDRQRMNLFVKESFPQL-DYPKGSAHENTI 2629
            .:  ||:.|     .::.|..::|:.|.|.|    ..|.:|...:.|...:: ..|..:|....|
Human  2481 MQ--IEQLE-----RYIQRYLVYAILWSLSG----DSRLKMRAELGEYIRRITTVPLPTAPNIPI 2534

  Fly  2630 FDFFVSPAGVWQSWKTLVTPYMYPE---LSTPDYLSILVPIVDNVRIDYLIGTIANQERAVMVIG 2691
            .|:.||.:|.|..|:..| |.:..|   ::.||   ::||.:|.||.:.|:.|...:.:.:::.|
Human  2535 IDYEVSISGEWSPWQAKV-PQIEVETHKVAAPD---VVVPTLDTVRHEALLYTWLAEHKPLVLCG 2595

  Fly  2692 EQGTGKTVIMKNFMKKMNVESYMGRSFNFSSATSPYQFQRTIESYVEKR---VGVTFGPPG-GRK 2752
            ..|:|||:.:.:.::.:.....:|  .||||||:|....:|.:.|.|.|   .||...|.. |:.
Human  2596 PPGSGKTMTLFSALRALPDMEVVG--LNFSSATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKW 2658

  Fly  2753 LIVFIDDINLPEINEWGDQITNEIVRQSMDMKGFYSLEKPGDFT--TIVDVQYVAAMGLP-GGGR 2814
            |::|.|:||||:::::|.|.....:||.::..|||   :..|.|  .:..:|:|.|...| ..||
Human  2659 LVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFY---RTSDQTWVKLERIQFVGACNPPTDPGR 2720

  Fly  2815 NDIPSRLKRQFCVFNCNIPDNDSIDKIFRVIGEGHYN-AKRGFVPEIRSLVKKLIVVTRHLWQRT 2878
            ..:..|..|...|...:.|...|:.:|:     |.:| |....:|.:|:..:.|.......:..:
Human  2721 KPLSHRFLRHVPVVYVDYPGPASLTQIY-----GTFNRAMLRLIPSLRTYAEPLTAAMVEFYTMS 2780

  Fly  2879 REKLLPTPAKFHYVFSLRDLSRIWQGMVGTLSTVIT-SESVLMALWKHECTRVFADRFTTFQDKE 2942
            :|: .....:.||::|.|:::|..:|:...|..:.| ....|:.:|.||..|:|.||....:::.
Human  2781 QER-FTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERR 2844

  Fly  2943 WFGSELACLVREELGDSHSQMILPNPVFVDFMRDAPEPTGEEGEDTDMELPKVYEPVHSHEV--- 3004
            |....:..:..:...:...:..:..|:.....                 |.|.|.||...|:
Human  2845 WTDENIDTVALKHFPNIDREKAMSRPILYSNW-----------------LSKDYIPVDQEELRDY 2892

  Fly  3005 LRERLVMFLAQFNEMVRGSGMDLVFFPDAMLHLVKISRIIRHPRGSVMLVGVGGSGKQSLTKLAS 3069
            ::.||.:|   :.|.:   .:.||.|.:.:.|:::|.||.|.|:|.::|:||.|:||.:|::..:
Human  2893 VKARLKVF---YEEEL---DVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVA 2951

  Fly  3070 FIAGYKTFQIALTRSYNVANFLEDLKLLYRTCGVQGKGTTFLFTDMDIKEEGFLEYLNNILSSGV 3134
            ::.|...:||.:.|.|...:|.|||:.:.|..|.:.:...|:..:.::.:.||||.:|.:|::|.
Human  2952 WMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVLDSGFLERMNTLLANGE 3016

  Fly  3135 ISNLFSRDEQAEIVQELTPVMKRENQRKTA----TPESVMDFFLARTCTNLHVAFCFSPVGETFR 3195
            :..||..||.|.::.:.     :|..:|..    :.|.:..:|.::...||||.|..:|..|..:
Human  3017 VPGLFEGDEYATLMTQC-----KEGAQKEGLMLDSHEELYKWFTSQVIRNLHVVFTMNPSSEGLK 3076

  Fly  3196 SRVQRFPALVSGCTIDWLHPWPKDALVSVARHFLSHFEIE------------------CTPAVKE 3242
            .|....|||.:.|.::|...|..:||..|.:.|.|..::|                  ..|:.:|
Human  3077 DRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNYIVPDYMPVVYDKLPQPPSHRE 3141

  Fly  3243 ELVNALGSIQDIVAETSQEYFQRFRRATHVTPKSYLNFIAGYKNIYQMKQQELRDGVEKMDTGLE 3307
            .:||:...:...:.:.:....:|..|...:||:.||:||..|.|::..|:.||.:....::.||.
Human  3142 AIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFINHYANLFHEKRSELEEQQMHLNVGLR 3206

  Fly  3308 KLKEASASVEILKKDLVVMEEELVEASKNAESVLVEVTERAMQAEIVKNQVLIVKDKAEALVACI 3372
            |:||....||.|::||.:..:||...:..|...|.::.:...:||..|.....::::.......|
Human  3207 KIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKKMVKDQQEAEKKKVMSQEIQEQLHKQQEVI 3271

  Fly  3373 AHEKALAEEKLEAAKPALEEAENALNTIKPAHIATVRKLGRPPHLIMRIMDCVLILFKRKLHPCI 3437
            |.::...:|.|:..:||:.||:||:.:||..|:..||.:..||..:...::.:.:|        :
Human  3272 ADKQMSVKEDLDKVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALESICLL--------L 3328

  Fly  3438 PDAGTPCPKPSWQESLKMMASATFLLQLQNYPKDTINDEMIDLLQP-YFRMEDYNMDMARR---V 3498
            .::.|     .|::...::....|:..:.|:..:.|:|.:.:.::. |.....||.::..|   .
Human  3329 GESTT-----DWKQIRSIIMRENFIPTIVNFSAEEISDAIREKMKKNYMSNPSYNYEIVNRASLA 3388

  Fly  3499 CGDVAGLLSWTKAMSFFHSVNKEVLPLKANLTMQEARLKLAMDDLAGAEEQLREREEALQAVKDQ 3563
            ||.   ::.|..|...:..:.|.|.||:..|...|...|.........|:.:|:.|.::...|::
Human  3389 CGP---MVKWAIAQLNYADMLKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEE 3450

  Fly  3564 YDKAVGEKQRLTDAANVCLRKMTAATALINGLSDEKHRWTNQSKEFKIQLGKLVGDVLLATGFLS 3628
            |...:.|.|.:.........|:..:|||:..||.|:.||...|:.||.|:..:.||.||:..|::
Human  3451 YAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIA 3515

  Fly  3629 YCGPYNQEFRANLIKTWMGILKQKNIPFTTGLNIINMLVDSSTVSEWTLQGLPNDELSVQNALIA 3693
            |.|.::|:.|.||..||...|:|.||.|.|.:.....|.::.....|....||.|:|..:||::.
Human  3516 YAGYFDQQMRQNLFTTWSHHLQQANIQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIML 3580

  Fly  3694 TKSSSYPLLVDPQTQGKIWIKCKEDRNELQITSLNHKYFRTHLEDSLSLGRPLLIEDVGIDLDPV 3758
            .:.:.|||::||..|...:|..:....::..||.....||.:||.:|..|.|||::||. ..|||
Human  3581 KRFNRYPLIIDPSGQATEFIMNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVE-SYDPV 3644

  Fly  3759 IDNVLEKNFIKSGSIEKVLVGDKECDVMPGFMLYITTKLPNPAFSPEVSAKTSIIDFTVTMRGLE 3823
            ::.||.:...::|....:.:||::.|:.|.|:::::|:.|...|.|::.::.:.::||||...|:
Human  3645 LNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQ 3709

  Fly  3824 DQLLGRVILMEKSDLEAERVALFETVMQNQRNMKELEANLLLRLSSSQGSLVDDEALIEVLRVTK 3888
            .|.|..|:..|:.|::.:|..|.:...:.|..:::||.:||..|:..:|.::||:.:|..|...|
Human  3710 SQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLK 3774

  Fly  3889 TTAEEVNQKLKISEVTERKIMKAREEFRAVAKRGSILYFLIVEMSNVNAMYQNSLKQFLVIFNHS 3953
            ..|.||.:|::.:::..:::....:::..::...|.:||.:..:..::.:||.||:.||.|:::.
Human  3775 REAAEVTRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNV 3839

  Fly  3954 ITKSTK-SSVTE--ERINIILRYLTYEVYKFTNRSLYERHKQLFTLMLA-IKIDYHNGNISHE-E 4013
            :.::.. ..||:  :|::||.:.|....:....|.:..:....|.::|| ||:....|..::: |
Human  3840 LYENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPTYDAE 3904

  Fly  4014 FLTFIKGGASLDLNAVTPKPFRWILDITWLN---LVEISKLETFSTVLQVIELNEKDWRCWYECE 4075
            |..|::|...:.....||:    |..:|...   :|.:|.|..|..::..::.:|: :..|.:..
Human  3905 FQHFLRGNEIVLSAGSTPR----IQGLTVEQAEAVVRLSCLPAFKDLIAKVQADEQ-FGIWLDSS 3964

  Fly  4076 KPE-------NEEIPCGYNAILDGFRKLLLIRSWCPDRTISQAKKYIEESLGPEYSEM--QILDL 4131
            .||       :||.|.  ..|.....:||||:::.|||.::.|..::..:||..:..:  |.|||
Human  3965 SPEQTVPYLWSEETPA--TPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSIMEQPLDL 4027

  Fly  4132 EE-MWLESEPRTPFVCLLSIGSDPTTQIGALAKQKSIVLKSVSMGQGQEYH-ARKMIIESMAIGG 4194
            .. :..|.:|.||.:.....|.|.:..:..||.:::..:.|:::|..:.:: |.|.|..::..|.
Human  4028 THIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQADKAINTAVKSGR 4092

  Fly  4195 WVLLQNVHLSLPFCSEIIDMLVESEHIDDSFRMWVTTEPHNEFPIGLLQMALKFTNEPPQGIRAS 4259
            ||:|:||||:..:..: ::..:.|......||:::|.|.:.:.|:.||:....|..|||.|::|:
Human  4093 WVMLKNVHLAPGWLMQ-LEKKLHSLQPHACFRLFLTMEINPKVPVNLLRAGRIFVFEPPPGVKAN 4156

  Fly  4260 LKRSYQSFTQDFLDYTSATQWPPLLYTVAFLHTIVQERRKFGPLGWNIPYEFNQADFAASVQFIQ 4324
            :.|::.|.....: ..|..:...|.:.:|:.|.|:|||.::.||||:..|||.::|..::...:.
Human  4157 MLRTFSSIPVSRI-CKSPNERARLYFLLAWFHAIIQERLRYAPLGWSKKYEFGESDLRSACDTVD 4220

  Fly  4325 NHLDEMDPKKG--------VSWQTLVYMIGEVQYGGRVTDDFDKRLLTTFTSVWFCEPLLSNSF- 4380
            ..||  |..||        :.|..|..::.:..|||||.::||:|||.||....|    .:.||
Human  4221 TWLD--DTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEFDQRLLNTFLERLF----TTRSFD 4279

  Fly  4381 -EFYKGYKVPGTKSLQ--------GFIDYINSLPAYDTPEVFGLHSNADITYQINSAKGILDTIL 4436
             ||....||.|.|.:|        .|:.::..||...||...||.:||:..........::..:|
Human  4280 SEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSWLGLPNNAERVLLTTQGVDMISKML 4344

  Fly  4437 SVQ--PKEGGGGGGETRES---------------IVYQLADDMLRKLPAQYNAYEVRENLTRM-- 4482
            .:|  ..|......||.:.               .::..|.:.|..:|      :...:|.|.
Human  4345 KMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTLHTTASNWLHLIP------QTLSHLKRTVE 4403

  Fly  4483 GILLPMNIFLRQEIDRMQRVIKRVHTCLCDLKLAIDGTIVMSPALKESLDAMYDARIPETWMKIS 4547
            .|..|:..|..:|:....::::.|...|.|:....:|....:..|:..::.:....:|.:|...:
Human  4404 NIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYT 4468

  Fly  4548 WES-TTLGFWYTELLERNGQFRTWISTDRPK---------VFWMTGFFNPQGFLTAMRQEVTRAH 4602
            ..: .|:..|.::..||..|.:. ||.....         ...:.|.|.|:.::||.||.|.:|:
Human  4469 VPAGMTVIQWVSDFSERIKQLQN-ISLAAASGGAKELKNIHVCLGGLFVPEAYITATRQYVAQAN 4532

  Fly  4603 KGWALDSVVLQNQITRYNKEDITEYPTEGVY-------VHGLFLEGASLDRRSGKLIESKMKVLY 4660
             .|:|:.:.|:..:|          .::|..       |.||.|:||:.:  :.||  |....:.
Human  4533 -SWSLEELCLEVNVT----------TSQGATLDACSFGVTGLKLQGATCN--NNKL--SLSNAIS 4582

  Fly  4661 EQMPVIYI-YAINTTAGKDPKLYECPIYRKPQRTDLKYVGSIDFE--TEFNPKHWTLRGVALLC 4721
            ..:|:..: :...|...|...:...|:|....|.||  :.::|||  |:.:|:.:..||||:||
Human  4583 TALPLTQLRWVKQTNTEKKASVVTLPVYLNFTRADL--IFTVDFEIATKEDPRSFYERGVAVLC 4644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9492	NP_001287256.1	DHC_N1	283..843	CDD:285571	114/650 (18%)
		DYN1	1178..4372	CDD:227570	943/3407 (28%)
		DHC_N2	1458..1861	CDD:285579	102/415 (25%)
		P-loop_NTPase	1994..2222	CDD:304359	120/236 (51%)
		P-loop_NTPase	2309..2444	CDD:304359	64/141 (45%)
		P-loop_NTPase	2662..2926	CDD:304359	73/272 (27%)
		P-loop_NTPase	3025..3287	CDD:304359	78/283 (28%)
		MT	3300..3646	CDD:289543	88/349 (25%)
		AAA_9	3674..3890	CDD:289547	66/215 (31%)
		Dynein_heavy	4031..4713	CDD:281078	184/752 (24%)
DYNC1H1	NP_001367.2	Stem. /evidence=ECO:0000250	53..1867		392/1944 (20%)
		DHC_N1	242..832	CDD:400611	133/809 (16%)
		Interaction with DYNC1I2. /evidence=ECO:0000250	448..703		59/340 (17%)
		Interaction with DYNC1LI2. /evidence=ECO:0000250	651..802		40/242 (17%)
		DYN1	1046..4329	CDD:227570	962/3455 (28%)
		AAA 1. /evidence=ECO:0000250	1868..2099		119/230 (52%)
		AAA 2. /evidence=ECO:0000250	2180..2452		97/312 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2390..2411		2/38 (5%)
		AAA 3. /evidence=ECO:0000250	2556..2805		71/262 (27%)
		AAA 4. /evidence=ECO:0000250	2899..3168		72/279 (26%)
		Stalk. /evidence=ECO:0000250	3189..3500		78/326 (24%)
		AAA 5. /evidence=ECO:0000250	3553..3782		70/229 (31%)
		AAA 6. /evidence=ECO:0000250	4005..4221		60/217 (28%)
		Dynein_C	4333..4644	CDD:408026	68/334 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710