DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAK and IME2

DIOPT Version :9

Sequence 1:	NP_001229886.1	Gene:	MAK / 4117	HGNCID:	6816	Length:	648	Species:	Homo sapiens
Sequence 2:	NP_012429.1	Gene:	IME2 / 853338	SGDID:	S000003642	Length:	645	Species:	Saccharomyces cerevisiae

Alignment Length:	617	Identity:	166/617 - (26%)
Similarity:	268/617 - (43%)	Gaps:	176/617 - (28%)

- Green bases have known domain annotations that are detailed below.

Human     2 NRYTTMRQLGDGTYGSVLMGK-----SNESGE-------------------------LVAIKRMK 36
            :||..:.:||.|::|.|.:.|     ||..|:                         :||||.|.
Yeast    36 DRYQLIEKLGAGSFGCVTLAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYITKTQGVVAIKTMM 100

Human    37 RKFYSWDECMNLREVKSLKKL-NHANVIKLKEVI--RENDHLYFIFEYMKENLYQLMKD-RNKLF 97
            .|.::..:...:||:|.:..: .:.::|::.||.  .||..|:.:.|.|::||||:||. |.::|
Yeast   101 TKLHTLQDYTRVREIKFILAIPANDHLIQIFEVFIDSENYQLHIVMECMEQNLYQMMKHRRRRVF 165

Human    98 PESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLC--------------MGPE---LVKIADFG 145
            ....:::|:.|||.||..||:|.|||||:||||:|.              :|.:   ::|:||||
Yeast   166 SIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFG 230

Human   146 LARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIF 210
            |||.:.::.|||.||||||||:||:||||..||.|:|:||.|.:..|:.:.|.||||.:|:|:|:
Yeast   231 LARHVENKNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEVTVFRALFPGANEIDQIW 295

Human   211 KICQVLGTP-KKSD---------------WPEGYQLASSMNFRFPQCVPINLKTLIPNAS-NEAI 258
            ||.:||||| |:||               |.:...|...:|.:.|.....:|..|:.::. ::..
Yeast   296 KILEVLGTPIKRSDFVNTNHITAPPPGGFWDDASNLVHKLNLKLPYVEGSSLDHLLSSSQLSDLS 360

Human   259 QLMTEMLNWDPKKRPTASQALKHPYFQ--VGQVLGPSSNHLESKQSL-----------------N 304
            :::.:.|.|||.:|.||.:..:.|:|:  |...:....|...::|:|                 |
Yeast   361 EVVKKCLRWDPNERATAQELCEMPFFENTVASQVDARGNVTNTEQALIFAGINPVATNTKPIYFN 425

Human   305 KQLQ-PLES-------------------------KPSLVEV---------EPKPLPDI------- 327
            ...: |.|:                         |.:|||.         :...:||:
Yeast   426 SSTKLPAETESNDIDISNNDHDSHAMCSPTLNQEKLTLVEFLNEFVEEDNDDHSIPDVGTDSTIS 490

Human   328 --IDQ------------VVGQPQPKTSQQPLQPIQPPQN-----------------LSVQQPPKQ 361
              ||:            :...|..:.....|..|:...|                 ..::.|.|.
Yeast   491 DSIDETELSKEIRNNLALCQLPDEEVLDHSLSNIRQLTNDIEIINKDEADNMEQLFFDLEIPEKD 555

Human   362 QSQEKPPQTLFPSIVKN--MPTKPNGTLSHKSGRRRWGQTIF---KSGDSWEELEDYDFGASHSK 421
            :.|.|.|......|.::  :|...|...:|.......|..:.   ..|||:..:.  ||...:..
Yeast   556 EFQRKQPFNEHADIDEDIVLPYVNNSNYTHTDRSHHRGDNVLGDASLGDSFNSMP--DFTPRNFL 618

Human   422 KPSMGVFKEKRKKDSPFRLPEPVPSGSNHSTG 453
            .|::   |:.|:|.      ||..|.||...|
Yeast   619 IPTL---KKSREKF------EPHLSNSNQHFG 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAK	NP_001229886.1	STKc_MAK_like	4..284	CDD:270824	120/347 (35%)
MAK	NP_001229886.1	S_TKc	4..284	CDD:214567	120/347 (35%)
IME2	NP_012429.1	STKc_MAK_like	38..386	CDD:270824	120/347 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I592
eggNOG	1	0.900	-	-		E1_KOG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	211	1.000	Inparanoid score	I916
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001823
OrthoInspector	1	1.000	-	-		otm53355
orthoMCL	1	0.900	-	-		OOG6_101384
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.860