Protein Alignment MAK and IME2

DIOPT Version :10

• Sequence 1: NP_001229886.1
• Gene: MAK / 4117
• HGNCID: 6816
• Length: 648
• Species: Homo sapiens
• Sequence 2: NP_012429.1
• Gene: IME2 / 853338
• SGDID: S000003642
• Length: 645
• Species: Saccharomyces cerevisiae
• Alignment Length: 617
• Identity: 166/617 - (26%)
• Similarity: 268/617 - (43%)
• Gaps: 176/617 - (28%)

Human     2 NRYTTMRQLGDGTYGSVLMGK-----SNESGE-------------------------LVAIKRMK 36
            :||..:.:||.|::|.|.:.|     ||..|:                         :||||.|.
Yeast    36 DRYQLIEKLGAGSFGCVTLAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYITKTQGVVAIKTMM 100

Human    37 RKFYSWDECMNLREVKSLKKL-NHANVIKLKEVI--RENDHLYFIFEYMKENLYQLMKD-RNKLF 97
            .|.::..:...:||:|.:..: .:.::|::.||.  .||..|:.:.|.|::||||:||. |.::|
Yeast   101 TKLHTLQDYTRVREIKFILAIPANDHLIQIFEVFIDSENYQLHIVMECMEQNLYQMMKHRRRRVF 165

Human    98 PESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLC--------------MGPE---LVKIADFG 145
            ....:::|:.|||.||..||:|.|||||:||||:|.              :|.:   ::|:||||
Yeast   166 SIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFG 230

Human   146 LARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIF 210
            |||.:.::.|||.||||||||:||:||||..||.|:|:||.|.:..|:.:.|.||||.:|:|:|:
Yeast   231 LARHVENKNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEVTVFRALFPGANEIDQIW 295

Human   211 KICQVLGTP-KKSD---------------WPEGYQLASSMNFRFPQCVPINLKTLIPNAS-NEAI 258
            ||.:||||| |:||               |.:...|...:|.:.|.....:|..|:.::. ::..
Yeast   296 KILEVLGTPIKRSDFVNTNHITAPPPGGFWDDASNLVHKLNLKLPYVEGSSLDHLLSSSQLSDLS 360

Human   259 QLMTEMLNWDPKKRPTASQALKHPYFQ--VGQVLGPSSNHLESKQSL-----------------N 304
            :::.:.|.|||.:|.||.:..:.|:|:  |...:....|...::|:|                 |
Yeast   361 EVVKKCLRWDPNERATAQELCEMPFFENTVASQVDARGNVTNTEQALIFAGINPVATNTKPIYFN 425

Human   305 KQLQ-PLES-------------------------KPSLVEV---------EPKPLPDI------- 327
            ...: |.|:                         |.:|||.         :...:||:
Yeast   426 SSTKLPAETESNDIDISNNDHDSHAMCSPTLNQEKLTLVEFLNEFVEEDNDDHSIPDVGTDSTIS 490

Human   328 --IDQ------------VVGQPQPKTSQQPLQPIQPPQN-----------------LSVQQPPKQ 361
              ||:            :...|..:.....|..|:...|                 ..::.|.|.
Yeast   491 DSIDETELSKEIRNNLALCQLPDEEVLDHSLSNIRQLTNDIEIINKDEADNMEQLFFDLEIPEKD 555

Human   362 QSQEKPPQTLFPSIVKN--MPTKPNGTLSHKSGRRRWGQTIF---KSGDSWEELEDYDFGASHSK 421
            :.|.|.|......|.::  :|...|...:|.......|..:.   ..|||:..:.  ||...:..
Yeast   556 EFQRKQPFNEHADIDEDIVLPYVNNSNYTHTDRSHHRGDNVLGDASLGDSFNSMP--DFTPRNFL 618

Human   422 KPSMGVFKEKRKKDSPFRLPEPVPSGSNHSTG 453
            .|::   |:.|:|.      ||..|.||...|
Yeast   619 IPTL---KKSREKF------EPHLSNSNQHFG 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAK	NP_001229886.1	STKc_MAK_like	4..284	CDD:270824	120/347 (35%)
IME2	NP_012429.1	STKc_MAK_like	38..386	CDD:270824	120/347 (35%)