Protein Alignment MAK and dyf-5

DIOPT Version :9

• Sequence 1: NP_001229886.1
• Gene: MAK / 4117
• HGNCID: 6816
• Length: 648
• Species: Homo sapiens
• Sequence 2: NP_001129786.2
• Gene: dyf-5 / 187442
• WormBaseID: WBGene00001121
• Length: 489
• Species: Caenorhabditis elegans
• Alignment Length: 649
• Identity: 266/649 - (40%)
• Similarity: 359/649 - (55%)
• Gaps: 176/649 - (27%)

Human     2 NRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLK 66
            :||...::|||||:|.|::.|..::|:.|||||||:|||||:|.|:||||||||||||.|:|||:
 Worm     9 DRYLMTKRLGDGTFGEVMLAKKIDTGDRVAIKRMKKKFYSWEEAMSLREVKSLKKLNHPNIIKLR 73

Human    67 EVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENL 131
            |||||||.|||:||:|:||||:|||||::.|||||||||:||:||||||:||:|||||||||||:
 Worm    74 EVIRENDILYFVFEFMQENLYELMKDRDRYFPESVIRNIIYQVLQGLAFMHKNGFFHRDMKPENI 138

Human   132 LCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYML 196
            :|.|.|||||||||||||:||:||||||||||||||||:||||:.|:||||:||:|.||||||:|
 Worm   139 MCNGTELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEILLRSTSYNSPIDMWALGCIMAELYIL 203

Human   197 RPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLM 261
            |||||||||:|::|||..:||||.|.:|||||||||:|||||.|.|...::.::...|.|.::||
 Worm   204 RPLFPGTSEMDQLFKIISILGTPNKDEWPEGYQLASAMNFRFQQVVATPMEQVVNTISKEGMKLM 268

Human   262 TEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESKQSLNKQLQPLESKPSLVEVEPKPLPD 326
            .:|:.|:|:|||.|:|:|::.||||.:.||                .|:.|:|:         |.
 Worm   269 MDMMLWNPEKRPNANQSLRYKYFQVAEKLG----------------APVVSQPA---------PG 308

Human   327 IIDQ-----VVGQPQPKTSQQPLQPIQPPQNLSVQQPPKQQSQEKPPQTLFPSIVKNMPTKPNGT 386
            .|.:     |....:..|::...:.....:|:|.|||.|         .:...|.:|:|...
 Worm   309 SIRKTSAASVKSDTKAMTAKAAKKDYIGSENVSPQQPAK---------VIDRHINRNLPLNK--- 361

Human   387 LSHKSGRRRWGQTIFKSGDSWEELEDYDFGASHSKKPSMGVFKEKRKKDSPFRLPEPVPSGSNHS 451
                       :|:|:..|:               || :|                  |:.||.:
 Worm   362 -----------ETLFEKSDN---------------KP-LG------------------PTKSNEA 381

Human   452 TGENKSLPAVTSLKSDSELSTAPTSKQYYLKQSRYLPGVNPKKVSLIASGKEINPHTWSNQLFPK 516
                                 .||:|:.||.:|:|:||             :::..|..||:...
 Worm   382 ---------------------KPTAKEIYLSKSKYVPG-------------QVSKDTHQNQIMTT 412

Human   517 SLGPVGAELAFKRSNAEESIIKPIEKLSCNETFPEKLEDPQGNLGSYATYNQS-GYIPSFLKKEV 580
            : |..|.                    :...||..|.|   |.......:..: ||||||
 Worm   413 N-GLTGT--------------------TKTTTFSAKKE---GRTAVQTRFEYAYGYIPSF----- 448

Human   581 QSAGQRIHLAPLNATASEYTWNTKTGRGQFSGRTYNPTAKNLNIVNRAQPIPSVHGRTDWVAKY 644
               |.|                 :|| ...|.:|.|.:|.|.:..|:.    |..||.||.|||
 Worm   449 ---GAR-----------------QTG-PTVSNQTNNHSANNSHSPNKM----SNTGRVDWAAKY 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAK	NP_001229886.1	STKc_MAK_like	4..284	CDD:270824	191/279 (68%)
		S_TKc	4..284	CDD:214567	191/279 (68%)
dyf-5	NP_001129786.2	STKc_MAK_like	11..291	CDD:270824	191/279 (68%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161452665
Domainoid	1	1.000	426	1.000	Domainoid score	I336
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I900
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D405578at33208
OrthoFinder	1	1.000	-	-		FOG0001823
OrthoInspector	1	1.000	-	-		otm15977
orthoMCL	1	0.900	-	-		OOG6_101384
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.900